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European Radiology
Published in: European Radiology 2/2015

01-02-2015 | Chest

Pulmonary adenocarcinomas appearing as part-solid ground-glass nodules: Is measuring solid component size a better prognostic indicator?

Authors: Eui Jin Hwang, Chang Min Park, Youngjin Ryu, Sang Min Lee, Young Tae Kim, Young Whan Kim, Jin Mo Goo

Published in: European Radiology | Issue 2/2015

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Abstract

Objective

To assess whether measuring the solid portion of adenocarcinomas appearing as part-solid ground-glass nodules (GGNs) can predict a patient’s prognosis accurately and how the prognosis corresponds to that of solid nodules.

Methods

501 patients (solid nodule group, 304; part-solid GGN group, 197) underwent curative surgery for stage I adenocarcinomas. Maximal diameters of the whole lesion including ground-glass opacities (D whole ) and solid components only (D solid ) were measured on CT. Disease-free survival (DFS) and overall survival (OS) were calculated from the date of surgery.

Results

D solid was a significant prognostic factor in the part-solid GGN group, while D whole was not. Part-solid GGNs with D solid ≤2 cm showed significantly better DFS (P = 0.016) and OS (P = 0.004) than solid nodules; however, those with D solid >2 cm did not show a significant difference. Hazard ratio (HR) for increase in D solid was significantly greater in part-solid GGNs than in solid nodules (P = 0.009). For OS, HR for increase in D solid was greater in part-solid GGNs than in solid nodule, which was marginally not significant (P = 0.060).

Conclusion

D solid was better than D whole for prognosis prediction of adenocarcinomas appearing as part-solid GGNs. In addition, the influence of D solid on prognosis in the part-solid GGN group was greater than in the solid nodule group.

Key points

• Dsolid is a better prognosis indicator than Dsolid in part-solid GGN adenocarcinomas
• Part-solid GGN adenocarcinoma show better prognosis than solid adenocarcinomas when Dsolid ≤2 cm
• Dsolid has greater prognostic influence in part-solid GGN adenocarcinomas than solid adenocarcinomas
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Metadata
Title
Pulmonary adenocarcinomas appearing as part-solid ground-glass nodules: Is measuring solid component size a better prognostic indicator?
Authors
Eui Jin Hwang
Chang Min Park
Youngjin Ryu
Sang Min Lee
Young Tae Kim
Young Whan Kim
Jin Mo Goo
Publication date
01-02-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 2/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3441-1

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