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Open Access 01-11-2016 | Interventional

First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation

Authors: Laura G. Merckel, Floor M. Knuttel, Roel Deckers, Thijs van Dalen, Gerald Schubert, Nicky H. G. M. Peters, Teun Weits, Paul J. van Diest, Willem P. Th. M. Mali, Paul H. H. B. Vaessen, Joost M. H. H. van Gorp, Chrit T. W. Moonen, Lambertus W. Bartels, Maurice A. A. J. van den Bosch

Published in: European Radiology | Issue 11/2016

Abstract

Objectives

To assess the safety and feasibility of MRI-guided high-intensity focused ultrasound (MR-HIFU) ablation in breast cancer patients using a dedicated breast platform.

Methods

Patients with early-stage invasive breast cancer underwent partial tumour ablation prior to surgical resection. MR-HIFU ablation was performed using proton resonance frequency shift MR thermometry and an MR-HIFU system specifically designed for breast tumour ablation. The presence and extent of tumour necrosis was assessed by histopathological analysis of the surgical specimen. Pearson correlation coefficients were calculated to assess the relationship between sonication parameters, temperature increase and size of tumour necrosis at histopathology.

Results

Ten female patients underwent MR-HIFU treatment. No skin redness or burns were observed in any of the patients. No correlation was found between the applied energy and the temperature increase. In six patients, tumour necrosis was observed with a maximum diameter of 3–11 mm. In these patients, the number of targeted locations was equal to the number of areas with tumour necrosis. A good correlation was found between the applied energy and the size of tumour necrosis at histopathology (Pearson = 0.76, p = 0.002).

Conclusions

Our results show that MR-HIFU ablation with the dedicated breast system is safe and results in histopathologically proven tumour necrosis.

Key Points

• MR-HIFU ablation with the dedicated breast system is safe and feasible

• In none of the patients was skin redness or burns observed

• No correlation was found between the applied energy and the temperature increase

• The correlation between applied energy and size of tumour necrosis was good

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Title: First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation
Authors: Laura G. Merckel
Floor M. Knuttel
Roel Deckers
Thijs van Dalen
Gerald Schubert
Nicky H. G. M. Peters
Teun Weits
Paul J. van Diest
Willem P. Th. M. Mali
Paul H. H. B. Vaessen
Joost M. H. H. van Gorp
Chrit T. W. Moonen
Lambertus W. Bartels
Maurice A. A. J. van den Bosch
Publication date: 01-11-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 11/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4222-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

First clinical experience with a dedicated MRI-guided high-intensity focused ultrasound system for breast cancer ablation

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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