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CardioVascular and Interventional Radiology

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01-04-2013 | Review

MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform

Authors: Laura G. Merckel, Lambertus W. Bartels, Max O. Köhler, H. J. G. Desirée van den Bongard, Roel Deckers, Willem P. Th. M. Mali, Christoph A. Binkert, Chrit T. Moonen, Kenneth G. A. Gilhuijs, Maurice A. A. J. van den Bosch

Published in: CardioVascular and Interventional Radiology | Issue 2/2013

Abstract

Optimizing the treatment of breast cancer remains a major topic of interest. In current clinical practice, breast-conserving therapy is the standard of care for patients with localized breast cancer. Technological developments have fueled interest in less invasive breast cancer treatment. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a completely noninvasive ablation technique. Focused beams of ultrasound are used for ablation of the target lesion without disrupting the skin and subcutaneous tissues in the beam path. MRI is an excellent imaging method for tumor targeting, treatment monitoring, and evaluation of treatment results. The combination of HIFU and MR imaging offers an opportunity for image-guided ablation of breast cancer. Previous studies of MR-HIFU in breast cancer patients reported a limited efficacy, which hampered the clinical translation of this technique. These prior studies were performed without an MR-HIFU system specifically developed for breast cancer treatment. In this article, a novel and dedicated MR-HIFU breast platform is presented. This system has been designed for safe and effective MR-HIFU ablation of breast cancer. Furthermore, both clinical and technical challenges are discussed, which have to be solved before MR-HIFU ablation of breast cancer can be implemented in routine clinical practice.

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Title: MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform
Authors: Laura G. Merckel
Lambertus W. Bartels
Max O. Köhler
H. J. G. Desirée van den Bongard
Roel Deckers
Willem P. Th. M. Mali
Christoph A. Binkert
Chrit T. Moonen
Kenneth G. A. Gilhuijs
Maurice A. A. J. van den Bosch
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: CardioVascular and Interventional Radiology / Issue 2/2013
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-012-0526-6

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MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform

Abstract

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