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Published in: European Radiology 8/2016

01-08-2016 | Breast

Evaluation of breast cancer using intravoxel incoherent motion (IVIM) histogram analysis: comparison with malignant status, histological subtype, and molecular prognostic factors

Authors: Gene Young Cho, Linda Moy, Sungheon G. Kim, Steven H. Baete, Melanie Moccaldi, James S. Babb, Daniel K. Sodickson, Eric E. Sigmund

Published in: European Radiology | Issue 8/2016

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Abstract

Purpose

To examine heterogeneous breast cancer through intravoxel incoherent motion (IVIM) histogram analysis.

Materials and methods

This HIPAA-compliant, IRB-approved retrospective study included 62 patients (age 48.44 ± 11.14 years, 50 malignant lesions and 12 benign) who underwent contrast-enhanced 3 T breast MRI and diffusion-weighted imaging. Apparent diffusion coefficient (ADC) and IVIM biomarkers of tissue diffusivity (Dt), perfusion fraction (fp), and pseudo-diffusivity (Dp) were calculated using voxel-based analysis for the whole lesion volume. Histogram analysis was performed to quantify tumour heterogeneity. Comparisons were made using Mann–Whitney tests between benign/malignant status, histological subtype, and molecular prognostic factor status while Spearman’s rank correlation was used to characterize the association between imaging biomarkers and prognostic factor expression.

Results

The average values of the ADC and IVIM biomarkers, Dt and fp, showed significant differences between benign and malignant lesions. Additional significant differences were found in the histogram parameters among tumour subtypes and molecular prognostic factor status. IVIM histogram metrics, particularly fp and Dp, showed significant correlation with hormonal factor expression.

Conclusion

Advanced diffusion imaging biomarkers show relationships with molecular prognostic factors and breast cancer malignancy. This analysis reveals novel diagnostic metrics that may explain some of the observed variability in treatment response among breast cancer patients.

Key Points

Novel IVIM biomarkers characterize heterogeneous breast cancer.
Histogram analysis enables quantification of tumour heterogeneity.
IVIM biomarkers show relationships with breast cancer malignancy and molecular prognostic factors.
Literature
2.
5.
go back to reference Jeh SK, Kim SH, Kim HS et al (2011) Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findings with prognostic factors in invasive ductal carcinoma. J Magn Reson Imaging 33:102–109CrossRefPubMed Jeh SK, Kim SH, Kim HS et al (2011) Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findings with prognostic factors in invasive ductal carcinoma. J Magn Reson Imaging 33:102–109CrossRefPubMed
6.
go back to reference Choi SY, Chang YW, Park HJ, Kim HJ, Hong SS, Seo DY (2012) Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer. Br J Radiol 85:e474–e479CrossRefPubMedPubMedCentral Choi SY, Chang YW, Park HJ, Kim HJ, Hong SS, Seo DY (2012) Correlation of the apparent diffusion coefficiency values on diffusion-weighted imaging with prognostic factors for breast cancer. Br J Radiol 85:e474–e479CrossRefPubMedPubMedCentral
7.
go back to reference Iima M, Le Bihan D, Okumura R et al (2011) Apparent diffusion coefficient as an MR imaging biomarker of low-risk ductal carcinoma in situ: a pilot study. Radiology 260:364–372CrossRefPubMed Iima M, Le Bihan D, Okumura R et al (2011) Apparent diffusion coefficient as an MR imaging biomarker of low-risk ductal carcinoma in situ: a pilot study. Radiology 260:364–372CrossRefPubMed
8.
go back to reference Kamitani T, Matsuo Y, Yabuuchi H et al (2013) Correlations between apparent diffusion coefficient values and prognostic factors of breast cancer. Magn Reson Med Sci MRMS Off J Jpn Soc Magn Reson Med 12:193–199 Kamitani T, Matsuo Y, Yabuuchi H et al (2013) Correlations between apparent diffusion coefficient values and prognostic factors of breast cancer. Magn Reson Med Sci MRMS Off J Jpn Soc Magn Reson Med 12:193–199
9.
go back to reference Basser PJ (1995) Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 8:333–344CrossRefPubMed Basser PJ (1995) Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 8:333–344CrossRefPubMed
10.
go back to reference Padhani AR, Liu G, Koh DM et al (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia 11:102–125CrossRefPubMedPubMedCentral Padhani AR, Liu G, Koh DM et al (2009) Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia 11:102–125CrossRefPubMedPubMedCentral
11.
go back to reference Sinha S, Lucas-Quesada FA, Sinha U, DeBruhl N, Bassett LW (2002) In vivo diffusion-weighted MRI of the breast: potential for lesion characterization. J Magn Reson Imaging 15:693–704CrossRefPubMed Sinha S, Lucas-Quesada FA, Sinha U, DeBruhl N, Bassett LW (2002) In vivo diffusion-weighted MRI of the breast: potential for lesion characterization. J Magn Reson Imaging 15:693–704CrossRefPubMed
12.
go back to reference Rahbar H, Partridge SC, Demartini WB et al (2012) In vivo assessment of ductal carcinoma in situ grade: a model incorporating dynamic contrast-enhanced and diffusion-weighted breast MR imaging parameters. Radiology 263:374–382CrossRefPubMedPubMedCentral Rahbar H, Partridge SC, Demartini WB et al (2012) In vivo assessment of ductal carcinoma in situ grade: a model incorporating dynamic contrast-enhanced and diffusion-weighted breast MR imaging parameters. Radiology 263:374–382CrossRefPubMedPubMedCentral
13.
go back to reference Partridge SC, Rahbar H, Murthy R et al (2011) Improved diagnostic accuracy of breast MRI through combined apparent diffusion coefficients and dynamic contrast-enhanced kinetics. Magn Reson Med 65:1759–1767CrossRefPubMedPubMedCentral Partridge SC, Rahbar H, Murthy R et al (2011) Improved diagnostic accuracy of breast MRI through combined apparent diffusion coefficients and dynamic contrast-enhanced kinetics. Magn Reson Med 65:1759–1767CrossRefPubMedPubMedCentral
14.
go back to reference Kim SH, Cha ES, Kim HS et al (2009) Diffusion-weighted imaging of breast cancer: correlation of the apparent diffusion coefficient value with prognostic factors. J Magn Reson Imaging 30:615–620CrossRefPubMed Kim SH, Cha ES, Kim HS et al (2009) Diffusion-weighted imaging of breast cancer: correlation of the apparent diffusion coefficient value with prognostic factors. J Magn Reson Imaging 30:615–620CrossRefPubMed
15.
go back to reference Iima M, Yano K, Kataoka M et al (2015) Quantitative non-gaussian diffusion and intravoxel incoherent motion magnetic resonance imaging: differentiation of malignant and benign breast lesions. Investig Radiol 50:205–211CrossRef Iima M, Yano K, Kataoka M et al (2015) Quantitative non-gaussian diffusion and intravoxel incoherent motion magnetic resonance imaging: differentiation of malignant and benign breast lesions. Investig Radiol 50:205–211CrossRef
16.
go back to reference Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505CrossRefPubMed Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505CrossRefPubMed
17.
go back to reference Luciani A, Vignaud A, Cavet M et al (2008) Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study. Radiology 249:891–899CrossRefPubMed Luciani A, Vignaud A, Cavet M et al (2008) Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study. Radiology 249:891–899CrossRefPubMed
18.
go back to reference Lemke A, Laun FB, Klauss M et al (2009) Differentiation of pancreas carcinoma from healthy pancreatic tissue using multiple b-values: comparison of apparent diffusion coefficient and intravoxel incoherent motion derived parameters. Investig Radiol 44:769–775CrossRef Lemke A, Laun FB, Klauss M et al (2009) Differentiation of pancreas carcinoma from healthy pancreatic tissue using multiple b-values: comparison of apparent diffusion coefficient and intravoxel incoherent motion derived parameters. Investig Radiol 44:769–775CrossRef
19.
go back to reference Gaing B, Sigmund EE, Huang WC et al (2015) Subtype differentiation of renal tumors using voxel-based histogram analysis of intravoxel incoherent motion parameters. Investig Radiol 50:144–152CrossRef Gaing B, Sigmund EE, Huang WC et al (2015) Subtype differentiation of renal tumors using voxel-based histogram analysis of intravoxel incoherent motion parameters. Investig Radiol 50:144–152CrossRef
20.
go back to reference Lu Y, Jansen JF, Mazaheri Y, Stambuk HE, Koutcher JA, Shukla-Dave A (2012) Extension of the intravoxel incoherent motion model to non-gaussian diffusion in head and neck cancer. J Magn Reson Imaging 36:1088–1096CrossRefPubMedPubMedCentral Lu Y, Jansen JF, Mazaheri Y, Stambuk HE, Koutcher JA, Shukla-Dave A (2012) Extension of the intravoxel incoherent motion model to non-gaussian diffusion in head and neck cancer. J Magn Reson Imaging 36:1088–1096CrossRefPubMedPubMedCentral
21.
go back to reference Thoeny HC, Zumstein D, Simon-Zoula S et al (2006) Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology 241:812–821CrossRefPubMed Thoeny HC, Zumstein D, Simon-Zoula S et al (2006) Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology 241:812–821CrossRefPubMed
22.
go back to reference Song YS, Park CM, Lee SM et al (2014) Reproducibility of histogram and texture parameters derived from intravoxel incoherent motion diffusion-weighted MRI of FN13762 rat breast Carcinomas. Anticancer Res 34:2135–2144PubMed Song YS, Park CM, Lee SM et al (2014) Reproducibility of histogram and texture parameters derived from intravoxel incoherent motion diffusion-weighted MRI of FN13762 rat breast Carcinomas. Anticancer Res 34:2135–2144PubMed
23.
go back to reference Kim S, Decarlo L, Cho GY et al (2012) Interstitial fluid pressure correlates with intravoxel incoherent motion imaging metrics in a mouse mammary carcinoma model. NMR Biomed 25:787–794CrossRefPubMed Kim S, Decarlo L, Cho GY et al (2012) Interstitial fluid pressure correlates with intravoxel incoherent motion imaging metrics in a mouse mammary carcinoma model. NMR Biomed 25:787–794CrossRefPubMed
24.
25.
go back to reference Cho GY, Moy L, Zhang JL et al (2014) Comparison of fitting methods and b-value sampling strategies for intravoxel incoherent motion in breast cancer. Magn Reson Med. doi:10.1002/mrm.25484 Cho GY, Moy L, Zhang JL et al (2014) Comparison of fitting methods and b-value sampling strategies for intravoxel incoherent motion in breast cancer. Magn Reson Med. doi:10.​1002/​mrm.​25484
26.
go back to reference Bokacheva L, Kaplan JB, Giri DD et al (2014) Intravoxel incoherent motion diffusion-weighted MRI at 3.0 T differentiates malignant breast lesions from benign lesions and breast parenchyma. J Magn Reson Imaging 40:813–823CrossRefPubMed Bokacheva L, Kaplan JB, Giri DD et al (2014) Intravoxel incoherent motion diffusion-weighted MRI at 3.0 T differentiates malignant breast lesions from benign lesions and breast parenchyma. J Magn Reson Imaging 40:813–823CrossRefPubMed
27.
go back to reference Sigmund EE, Cho GY, Kim S et al (2011) Intravoxel incoherent motion imaging of tumor microenvironment in locally advanced breast cancer. Magn Reson Med 65:1437–1447CrossRefPubMedPubMedCentral Sigmund EE, Cho GY, Kim S et al (2011) Intravoxel incoherent motion imaging of tumor microenvironment in locally advanced breast cancer. Magn Reson Med 65:1437–1447CrossRefPubMedPubMedCentral
28.
go back to reference Liu C, Liang C, Liu Z, Zhang S, Huang B (2013) Intravoxel incoherent motion (IVIM) in evaluation of breast lesions: comparison with conventional DWI. Eur J Radiol 82:e782–e789CrossRefPubMed Liu C, Liang C, Liu Z, Zhang S, Huang B (2013) Intravoxel incoherent motion (IVIM) in evaluation of breast lesions: comparison with conventional DWI. Eur J Radiol 82:e782–e789CrossRefPubMed
29.
go back to reference Wiederer J, Pazahr S, Leo C, Nanz D, Boss A (2014) Quantitative breast MRI: 2D histogram analysis of diffusion tensor parameters in normal tissue. MAGMA 27:185–193CrossRefPubMed Wiederer J, Pazahr S, Leo C, Nanz D, Boss A (2014) Quantitative breast MRI: 2D histogram analysis of diffusion tensor parameters in normal tissue. MAGMA 27:185–193CrossRefPubMed
30.
go back to reference Chandarana H, Rosenkrantz AB, Mussi TC et al (2012) Histogram analysis of whole-lesion enhancement in differentiating clear cell from papillary subtype of renal cell cancer. Radiology 265:790–798CrossRefPubMed Chandarana H, Rosenkrantz AB, Mussi TC et al (2012) Histogram analysis of whole-lesion enhancement in differentiating clear cell from papillary subtype of renal cell cancer. Radiology 265:790–798CrossRefPubMed
31.
go back to reference Lutz K, Wiestler B, Graf M et al (2014) Infiltrative patterns of glioblastoma: identification of tumor progress using apparent diffusion coefficient histograms. J Magn Reson Imaging 39:1096–1103CrossRefPubMed Lutz K, Wiestler B, Graf M et al (2014) Infiltrative patterns of glioblastoma: identification of tumor progress using apparent diffusion coefficient histograms. J Magn Reson Imaging 39:1096–1103CrossRefPubMed
32.
go back to reference Emblem KE, Scheie D, Due-Tonnessen P et al (2008) Histogram analysis of MR imaging–derived cerebral blood volume maps: combined glioma grading and identification of low-grade oligodendroglial subtypes. Am J Neuroradiol 29:1664–1670CrossRefPubMed Emblem KE, Scheie D, Due-Tonnessen P et al (2008) Histogram analysis of MR imaging–derived cerebral blood volume maps: combined glioma grading and identification of low-grade oligodendroglial subtypes. Am J Neuroradiol 29:1664–1670CrossRefPubMed
33.
go back to reference Baltzer PA, Renz DM, Herrmann KH et al (2009) Diffusion-weighted imaging (DWI) in MR mammography (MRM): clinical comparison of echo planar imaging (EPI) and half-Fourier single-shot turbo spin echo (HASTE) diffusion techniques. Eur Radiol 19:1612–1620CrossRefPubMed Baltzer PA, Renz DM, Herrmann KH et al (2009) Diffusion-weighted imaging (DWI) in MR mammography (MRM): clinical comparison of echo planar imaging (EPI) and half-Fourier single-shot turbo spin echo (HASTE) diffusion techniques. Eur Radiol 19:1612–1620CrossRefPubMed
34.
go back to reference Kinoshita T, Yashiro N, Ihara N, Funatu H, Fukuma E, Narita M (2002) Diffusion-weighted half-Fourier single-shot turbo spin echo imaging in breast tumors: differentiation of invasive ductal carcinoma from fibroadenoma. J Comput Assist Tomogr 26:1042–1046CrossRefPubMed Kinoshita T, Yashiro N, Ihara N, Funatu H, Fukuma E, Narita M (2002) Diffusion-weighted half-Fourier single-shot turbo spin echo imaging in breast tumors: differentiation of invasive ductal carcinoma from fibroadenoma. J Comput Assist Tomogr 26:1042–1046CrossRefPubMed
35.
go back to reference ACR (2003) Breast imaging reporting and data system (BI-RADS). American College of Radiology, Reston, VA ACR (2003) Breast imaging reporting and data system (BI-RADS). American College of Radiology, Reston, VA
36.
go back to reference Sharma U, Danishad KKA, Seenu V, Jagannathan NR (2009) Longitudinal study of the assessment by MRI and diffusion-weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. NMR Biomed 22:104–113CrossRefPubMed Sharma U, Danishad KKA, Seenu V, Jagannathan NR (2009) Longitudinal study of the assessment by MRI and diffusion-weighted imaging of tumor response in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. NMR Biomed 22:104–113CrossRefPubMed
37.
go back to reference Wirestam R, Borg M, Brockstedt S, Lindgren A, Holtas S, Stahlberg F (2001) Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique. Acta Radiol 42:123–128CrossRefPubMed Wirestam R, Borg M, Brockstedt S, Lindgren A, Holtas S, Stahlberg F (2001) Perfusion-related parameters in intravoxel incoherent motion MR imaging compared with CBV and CBF measured by dynamic susceptibility-contrast MR technique. Acta Radiol 42:123–128CrossRefPubMed
38.
go back to reference Moteki T, Horikoshi H (2006) Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted echo-planar MR with three values of gradient b-factor. J Magn Reson Imaging 24:637–645CrossRefPubMed Moteki T, Horikoshi H (2006) Evaluation of hepatic lesions and hepatic parenchyma using diffusion-weighted echo-planar MR with three values of gradient b-factor. J Magn Reson Imaging 24:637–645CrossRefPubMed
39.
go back to reference Callot V, Bennett E, Decking UK, Balaban RS, Wen H (2003) In vivo study of microcirculation in canine myocardium using the IVIM method. Magn Reson Med 50:531–540CrossRefPubMedPubMedCentral Callot V, Bennett E, Decking UK, Balaban RS, Wen H (2003) In vivo study of microcirculation in canine myocardium using the IVIM method. Magn Reson Med 50:531–540CrossRefPubMedPubMedCentral
40.
go back to reference Yao L, Sinha U (2000) Imaging the microcirculatory proton fraction of muscle with diffusion-weighted echo-planar imaging. Acad Radiol 7:27–32CrossRefPubMed Yao L, Sinha U (2000) Imaging the microcirculatory proton fraction of muscle with diffusion-weighted echo-planar imaging. Acad Radiol 7:27–32CrossRefPubMed
41.
go back to reference Pekar J, Moonen CT, van Zijl PC (1992) On the precision of diffusion/perfusion imaging by gradient sensitization. Magn Reson Med 23:122–129CrossRefPubMed Pekar J, Moonen CT, van Zijl PC (1992) On the precision of diffusion/perfusion imaging by gradient sensitization. Magn Reson Med 23:122–129CrossRefPubMed
42.
go back to reference Guiu B, Petit JM, Capitan V et al (2012) Intravoxel incoherent motion diffusion–weighted Imaging in nonalcoholic fatty liver disease: a 3.0–T MR study. Radiology 265:96–103CrossRefPubMed Guiu B, Petit JM, Capitan V et al (2012) Intravoxel incoherent motion diffusion–weighted Imaging in nonalcoholic fatty liver disease: a 3.0–T MR study. Radiology 265:96–103CrossRefPubMed
43.
go back to reference Sumi M, Nakamura T (2013) Head and neck tumors: assessment of perfusion–related parameters and diffusion coefficients based on the intravoxel incoherent motion model. AJNR Am J Neuroradiol 34:410–416CrossRefPubMed Sumi M, Nakamura T (2013) Head and neck tumors: assessment of perfusion–related parameters and diffusion coefficients based on the intravoxel incoherent motion model. AJNR Am J Neuroradiol 34:410–416CrossRefPubMed
44.
45.
go back to reference Adams S, Chakravarthy AB, Donach M et al (2010) Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival. Breast Cancer Res Treat 124:723–732CrossRefPubMedPubMedCentral Adams S, Chakravarthy AB, Donach M et al (2010) Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival. Breast Cancer Res Treat 124:723–732CrossRefPubMedPubMedCentral
46.
go back to reference Prat A, Perou CM (2011) Deconstructing the molecular portraits of breast cancer. Mol Oncol 5:5–23CrossRefPubMed Prat A, Perou CM (2011) Deconstructing the molecular portraits of breast cancer. Mol Oncol 5:5–23CrossRefPubMed
47.
go back to reference Yue W, Wang JP, Li Y et al (2005) Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res 11:925s–930sPubMed Yue W, Wang JP, Li Y et al (2005) Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res 11:925s–930sPubMed
48.
go back to reference Pequeux C, Raymond-Letron I, Blacher S et al (2012) Stromal estrogen receptor-alpha promotes tumor growth by normalizing an increased angiogenesis. Cancer Res 72:3010–3019CrossRefPubMed Pequeux C, Raymond-Letron I, Blacher S et al (2012) Stromal estrogen receptor-alpha promotes tumor growth by normalizing an increased angiogenesis. Cancer Res 72:3010–3019CrossRefPubMed
49.
go back to reference Hyder SM, Murthy L, Stancel GM (1998) Progestin regulation of vascular endothelial growth factor in human breast cancer cells. Cancer Res 58:392–395PubMed Hyder SM, Murthy L, Stancel GM (1998) Progestin regulation of vascular endothelial growth factor in human breast cancer cells. Cancer Res 58:392–395PubMed
50.
go back to reference Stendahl M, Ryden L, Nordenskjold B, Jonsson PE, Landberg G, Jirstrom K (2006) High progesterone receptor expression correlates to the effect of adjuvant tamoxifen in premenopausal breast cancer patients. Clin Cancer Res 12:4614–4618CrossRefPubMed Stendahl M, Ryden L, Nordenskjold B, Jonsson PE, Landberg G, Jirstrom K (2006) High progesterone receptor expression correlates to the effect of adjuvant tamoxifen in premenopausal breast cancer patients. Clin Cancer Res 12:4614–4618CrossRefPubMed
51.
go back to reference Zhang JL, Sigmund EE, Rusinek H et al (2012) Optimization of b-value sampling for diffusion-weighted imaging of the kidney. Magn Reson Med 67:89–97CrossRefPubMed Zhang JL, Sigmund EE, Rusinek H et al (2012) Optimization of b-value sampling for diffusion-weighted imaging of the kidney. Magn Reson Med 67:89–97CrossRefPubMed
52.
go back to reference Dyvorne HA, Galea N, Nevers T et al (2013) Diffusion-weighted imaging of the liver with multiple b-values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters--a pilot study. Radiology 266:920–929CrossRefPubMedPubMedCentral Dyvorne HA, Galea N, Nevers T et al (2013) Diffusion-weighted imaging of the liver with multiple b-values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters--a pilot study. Radiology 266:920–929CrossRefPubMedPubMedCentral
53.
go back to reference Nilsen LB, Fangberget A, Geier O, Seierstad T (2013) Quantitative analysis of diffusion-weighted magnetic resonance imaging in malignant breast lesions using different b-value combinations. Eur Radiol 23:1027–1033CrossRefPubMed Nilsen LB, Fangberget A, Geier O, Seierstad T (2013) Quantitative analysis of diffusion-weighted magnetic resonance imaging in malignant breast lesions using different b-value combinations. Eur Radiol 23:1027–1033CrossRefPubMed
54.
go back to reference Neil JJ, Bretthorst GL (1993) On the use of Bayesian probability theory for analysis of exponential decay data: an example taken from intravoxel incoherent motion experiments. Magn Reson Med 29:642–647CrossRefPubMed Neil JJ, Bretthorst GL (1993) On the use of Bayesian probability theory for analysis of exponential decay data: an example taken from intravoxel incoherent motion experiments. Magn Reson Med 29:642–647CrossRefPubMed
55.
go back to reference Barbieri S, Donati OF, Froehlich JM, Thoeny HC (2015) Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs. Magn Reson Med. doi:10.1002/mrm.25765 PubMed Barbieri S, Donati OF, Froehlich JM, Thoeny HC (2015) Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs. Magn Reson Med. doi:10.​1002/​mrm.​25765 PubMed
56.
go back to reference Orton MR, Collins DJ, Koh DM, Leach MO (2014) Improved intravoxel incoherent motion analysis of diffusion weighted imaging by data driven Bayesian modeling. Magn Reson Med 71:411–420CrossRefPubMed Orton MR, Collins DJ, Koh DM, Leach MO (2014) Improved intravoxel incoherent motion analysis of diffusion weighted imaging by data driven Bayesian modeling. Magn Reson Med 71:411–420CrossRefPubMed
57.
go back to reference Wurnig MC, Donati OF, Ulbrich E et al (2014) Systematic analysis of the intravoxel incoherent motion threshold separating perfusion and diffusion effects: proposal of a standardized algorithm. Magn Reson Med. doi:10.1002/mrm.25506 PubMed Wurnig MC, Donati OF, Ulbrich E et al (2014) Systematic analysis of the intravoxel incoherent motion threshold separating perfusion and diffusion effects: proposal of a standardized algorithm. Magn Reson Med. doi:10.​1002/​mrm.​25506 PubMed
58.
go back to reference Freiman M, Voss SD, Mulkern RV, Perez-Rossello JM, Callahan MJ, Warfield SK (2012) Reliable assessment of perfusivity and diffusivity from diffusion imaging of the body. Med Image Comput Comput Assist Interv 15:1–9PubMedPubMedCentral Freiman M, Voss SD, Mulkern RV, Perez-Rossello JM, Callahan MJ, Warfield SK (2012) Reliable assessment of perfusivity and diffusivity from diffusion imaging of the body. Med Image Comput Comput Assist Interv 15:1–9PubMedPubMedCentral
59.
go back to reference Quentin M, Blondin D, Klasen J et al (2012) Comparison of different mathematical models of diffusion-weighted prostate MR imaging. Magn Reson Imaging 30:1468–1474CrossRefPubMed Quentin M, Blondin D, Klasen J et al (2012) Comparison of different mathematical models of diffusion-weighted prostate MR imaging. Magn Reson Imaging 30:1468–1474CrossRefPubMed
61.
go back to reference Freiman M, Voss SD, Mulkern RV, Perez-Rossello JM, Callahan MJ, Warfield SK (2012) In vivo assessment of optimal b-value range for perfusion-insensitive apparent diffusion coefficient imaging. Med Phys 39:4832–4839CrossRefPubMedPubMedCentral Freiman M, Voss SD, Mulkern RV, Perez-Rossello JM, Callahan MJ, Warfield SK (2012) In vivo assessment of optimal b-value range for perfusion-insensitive apparent diffusion coefficient imaging. Med Phys 39:4832–4839CrossRefPubMedPubMedCentral
62.
go back to reference Freiman M, Perez-Rossello JM, Callahan MJ et al (2013) Reliable estimation of incoherent motion parametric maps from diffusion-weighted MRI using fusion bootstrap moves. Med Image Anal 17:325–336CrossRefPubMedPubMedCentral Freiman M, Perez-Rossello JM, Callahan MJ et al (2013) Reliable estimation of incoherent motion parametric maps from diffusion-weighted MRI using fusion bootstrap moves. Med Image Anal 17:325–336CrossRefPubMedPubMedCentral
63.
go back to reference Wu LM, Hu J, Xu JR (2012) MRI in residual tumor size measurement in patient with breast cancer receiving neoadjuvant chemotherapy calls for caution. Breast Cancer Res Treat 135:319–320CrossRefPubMed Wu LM, Hu J, Xu JR (2012) MRI in residual tumor size measurement in patient with breast cancer receiving neoadjuvant chemotherapy calls for caution. Breast Cancer Res Treat 135:319–320CrossRefPubMed
64.
go back to reference Prevos R, Smidt ML, Tjan-Heijnen VC et al (2012) Pre-treatment differences and early response monitoring of neoadjuvant chemotherapy in breast cancer patients using magnetic resonance imaging: a systematic review. Eur Radiol 22:2607–2616CrossRefPubMed Prevos R, Smidt ML, Tjan-Heijnen VC et al (2012) Pre-treatment differences and early response monitoring of neoadjuvant chemotherapy in breast cancer patients using magnetic resonance imaging: a systematic review. Eur Radiol 22:2607–2616CrossRefPubMed
Metadata
Title
Evaluation of breast cancer using intravoxel incoherent motion (IVIM) histogram analysis: comparison with malignant status, histological subtype, and molecular prognostic factors
Authors
Gene Young Cho
Linda Moy
Sungheon G. Kim
Steven H. Baete
Melanie Moccaldi
James S. Babb
Daniel K. Sodickson
Eric E. Sigmund
Publication date
01-08-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4087-3

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