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European Radiology
Published in: European Radiology 6/2016

01-06-2016 | Gastrointestinal

Quantitative assessment of hepatic function: modified look-locker inversion recovery (MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging

Authors: Jeong Hee Yoon, Jeong Min Lee, Munyoung Paek, Joon Koo Han, Byung Ihn Choi

Published in: European Radiology | Issue 6/2016

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Abstract

Objectives

To determine whether multislice T1 mapping of the liver using a modified look-locker inversion recovery (MOLLI) sequence on gadoxetic acid-enhanced magnetic resonance imaging (MRI) can be used as a quantitative tool to estimate liver function and predict the presence of oesophageal or gastric varices.

Methods

Phantoms filled with gadoxetic acid were scanned three times using MOLLI sequence to test repeatability. Patients with chronic liver disease or liver cirrhosis who underwent gadoxetic acid-enhanced liver MRI including MOLLI sequence at 3 T were included (n = 343). Pre- and postcontrast T1 relaxation times of the liver (T1liver), changes between pre- and postcontrast T1liver (ΔT1liver), and adjusted postcontrast T1liver (postcontrast T1liver-T1spleen/T1spleen) were compared among Child-Pugh classes. In 62 patients who underwent endoscopy, all T1 parameters and spleen sizes were correlated with varices.

Results

Phantom study showed excellent repeatability of MOLLI sequence. As Child-Pugh scores increased, pre- and postcontrast T1liver were significantly prolonged (P < 0.001), and ΔT1liver and adjusted postcontrast T1liver decreased (P < 0.001). Adjusted postcontrast T1liver and spleen size were independently associated with varices (R 2 = 0.29, P < 0.001).

Conclusions

T1 mapping of the liver using MOLLI sequence on gadoxetic acid-enhanced MRI demonstrated potential in quantitatively estimating liver function, and adjusted postcontrast T1liver was significantly associated with varices.

Key Points

• T1 mapping using MOLLI sequence can be achieved within a breath-hold.
• T1liver measured by MOLLI sequence provided excellent short-term repeatability.
• Precontrast and postcontrast T1liver were significantly prolonged as Child-Pugh scores increased.
• Adjusted postcontrast T1liver and spleen size were independently associated with varices.
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Metadata
Title
Quantitative assessment of hepatic function: modified look-locker inversion recovery (MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging
Authors
Jeong Hee Yoon
Jeong Min Lee
Munyoung Paek
Joon Koo Han
Byung Ihn Choi
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3994-7

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