Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 6/2016

01-06-2016 | Magnetic Resonance

Age dependence of spleen- and muscle-corrected hepatic signal enhancement on hepatobiliary phase gadoxetate MRI

Authors: Simon Matoori, Johannes M. Froehlich, Stefan Breitenstein, Aleksis Doert, Viktoria Pozdniakova, Dow-Mu Koh, Andreas Gutzeit

Published in: European Radiology | Issue 6/2016

Login to get access

Abstract

Objectives

To identify correlations of signal enhancements (SE) and SE normalized to reference tissues of the spleen, kidney, liver, musculus erector spinae (MES) and ductus hepatocholedochus (DHC) on hepatobiliary phase gadoxetate-enhanced MRI with patient age in non-cirrhotic patients.

Methods

A heterogeneous cohort of 131 patients with different clinical backgrounds underwent a standardized 3.0-T gadoxetate-enhanced liver MRI between November 2008 and June 2013. After exclusion of cirrhotic patients, a cohort of 75 patients with no diagnosed diffuse liver disease was selected. The ratio of signal intensity 20 min post- to pre-contrast administration (SE) in the spleen, kidney, liver, MES and DHC, and the SE of the kidney, liver and DHC normalized to the reference tissues spleen or MES were compared to patient age.

Results

Patient age was inversely correlated with the liver SE normalized to the spleen and MES SE (both p < 0.001) and proportionally with the SE of the spleen (p = 0.043), the MES (p = 0.030) and the kidney (p = 0.022). No significant correlations were observed for the DHC (p = 0.347) and liver SE (p = 0.606).

Conclusion

The age dependence of hepatic SE normalized to the enhancement in the spleen and MES calls for a cautious interpretation of these quantification methods.

Key Points

• Patient age was inversely correlated with spleen- and MES-corrected liver rSE (p < 0.001).
• Patient age was correlated with spleen (p = 0.043) and MES SE (p = 0.030).
• Patient age may confound quantitative liver function assessment using gadoxetate-enhanced liver MRI.
Appendix
Available only for authorised users
Literature
1.
2.
Van Beers BE, Pastor CM, Hussain HK (2012) Primovist, Eovist: what to expect? J Hepatol 57:421–429CrossRefPubMed
3.
Lee NK, Kim S, Lee JW et al (2009) Biliary MR imaging with Gd-EOB-DTPA and its clinical applications. Radiographics 29:1707–1724CrossRefPubMed
4.
Kukuk G, Schaefer S, Fimmers R et al (2014) Hepatobiliary magnetic resonance imaging in patients with liver disease: correlation of liver enhancement with biochemical liver function tests. Eur Rad 24(10):2482–2490CrossRef
5.
Motosugi U, Ichikawa T, Sou H et al (2009) Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? JMRI 30:1042–1046CrossRefPubMed
6.
Yamada A, Hara T, Li F et al (2011) Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology 260:727–733CrossRefPubMed
7.
Katsube T, Okada M, Kumano S et al (2012) Estimation of liver function using T2* mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging. Eur J Radiol 81:1460–1464CrossRefPubMed
8.
Nishie A, Ushijima Y, Tajima T et al (2012) Quantitative analysis of liver function using superparamagnetic iron oxide- and Gd-EOB-DTPA-enhanced MRI: comparison with technetium-99m galactosyl serum albumin scintigraphy. Eur J Radiol 81:1100–1104CrossRefPubMed
9.
Nilsson H, Blomqvist L, Douglas L et al (2013) Gd-EOB-DTPA-enhanced MRI for the assessment of liver function and volume in liver cirrhosis. Br J Radiol 86:20120653CrossRefPubMedPubMedCentral
10.
Haimerl M, Verloh N, Fellner C et al (2014) MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score. Sci Rep 4:5621CrossRefPubMedPubMedCentral
11.
Kubota KEI, Tamura T, Aoyama N et al (2012) Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma. Oncol Lett 3:990–994PubMedPubMedCentral
12.
Nilsson H, Blomqvist L, Douglas L, Nordell A, Jonas E (2010) Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI. HPB 12:567–576CrossRefPubMedPubMedCentral
13.
Saito K, Ledsam J, Sourbron S et al (2013) Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. JMRI 37:1109–1114CrossRefPubMed
14.
Yoneyama T, Fukukura Y, Kamimura K et al (2014) Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function. Eur Radiol 24:857–865CrossRefPubMed
15.
Kamimura K, Fukukura Y, Yoneyama T et al (2014) Quantitative evaluation of liver function with T1 relaxation time index on Gd-EOB-DTPA-enhanced MRI: comparison with signal intensity-based indices. J Magn Reson Imaging 40:884–889CrossRefPubMed
16.
Ding Y, Rao S-X, Chen C, Li R, Zeng M-S (2015) Assessing liver function in patients with HBV-related HCC: a comparison of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI. Eur Radiol 25:1392–1398CrossRefPubMed
17.
Leonhardt M, Keiser M, Oswald S et al (2010) Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos 38:1024–1028CrossRefPubMed
18.
Geier A, Kim SK, Gerloff T et al (2002) Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J Hepatol 37:198–205CrossRefPubMed
19.
Geier A, Dietrich CG, Voigt S et al (2003) Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 38:345–354CrossRefPubMed
20.
Tsuda N, Okada M, Murakami T (2007) Potential of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging. Invest Radiol 42:242–247CrossRefPubMed
21.
Tsuda N, Matsui O (2010) Cirrhotic rat liver: reference to transporter activity and morphologic changes in bile canaliculi—gadoxetic acid-enhanced MR imaging. Radiology 256:767–773CrossRefPubMed
22.
Tsuda N, Matsui O (2011) Signal profile on Gd-EOB-DTPA-enhanced MR imaging in non-alcoholic steatohepatitis and liver cirrhosis induced in rats: correlation with transporter expression. Eur Radiol 21:2542–2550CrossRefPubMed
23.
Mori T, Okanoue T, Sawa Y, Hori N, Ohta M, Kagawa K (1993) Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis. Hepatology 17:891–897CrossRefPubMed
24.
Joseph AEA, Saverymuttu SH, Al-Sam S, Cook MG, Maxwell JD (1991) Comparison of liver histology with ultrasonography in assessing diffuse parenchymal liver disease. Clin Radiol 43:26–31CrossRefPubMed
25.
26.
Schmucker D (2001) Liver function and phase I drug metabolism in the elderly. Drugs Aging 18:837–851CrossRefPubMed
27.
Mooij MG, Schwarz UI, de Koning BAE et al (2014) Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters. Drug Metab Dispos 42:1268–1274CrossRefPubMedPubMedCentral
28.
Gschwend S, Ebert W, Schultze-Mosgau M, Breuer J (2011) Pharmacokinetics and imaging properties of Gd-EOB-DTPA in patients with hepatic and renal impairment. Invest Radiol 46:556–566CrossRefPubMed
29.
Verloh N, Haimerl M, Zeman F et al (2015) Multivariable analysis of clinical influence factors on liver enhancement of Gd-EOB-DTPA-enhanced 3T. Röfo 187:29–35PubMed
30.
Baumann D, Rudin M (2000) Quantitative assessment of rat kidney function by measuring the clearance of the contrast agent Gd(DOTA) using dynamic MRI. Magn Reson Imaging 18:587–595CrossRefPubMed
Metadata
Title
Age dependence of spleen- and muscle-corrected hepatic signal enhancement on hepatobiliary phase gadoxetate MRI
Authors
Simon Matoori
Johannes M. Froehlich
Stefan Breitenstein
Aleksis Doert
Viktoria Pozdniakova
Dow-Mu Koh
Andreas Gutzeit
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3965-z

Other articles of this Issue 6/2016

European Radiology 6/2016 Go to the issue

Neuro

Topographic organization of motor fibre tracts in the human brain: findings in multiple locations using magnetic resonance diffusion tensor tractography

Head and Neck

The value of a rapid contrast-enhanced angio-MRI protocol in the detection of head and neck paragangliomas in SDHx mutations carriers: a retrospective study on behalf of the PGL.EVA investigators*

Oncology

Metastatic patterns and metastatic sites in mucosal melanoma: a retrospective study

Nuclear Medicine

Clinical role of early dynamic FDG-PET/CT for the evaluation of renal cell carcinoma

Magnetic Resonance

Feasibility of a three-step magnetic resonance imaging approach for the assessment of hepatic steatosis in an asymptomatic study population

Hepatobiliary-Pancreas

Differentiation of intrahepatic mass-forming cholangiocarcinoma from hepatocellular carcinoma on gadoxetic acid-enhanced liver MR imaging