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European Radiology

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01-05-2016 | Neuro

Prognosis of spontaneous cervical artery dissection and transcranial Doppler findings associated with clinical outcomes

Authors: Woo-Jin Lee, Keun-Hwa Jung, Jangsup Moon, Soon-Tae Lee, Kon Chu, Sang-Kun Lee, Jae-Kyu Roh

Published in: European Radiology | Issue 5/2016

Abstract

Objectives

We categorised spontaneous cervical artery dissection (sCAD) by radiological features and investigated factors associated with favourable outcomes.

Methods

We retrospectively analysed 128 patients with sCAD with a median follow-up duration of 25 months. Twenty-nine constituted the aneurysm group, 52 the stenotic group, and 47 the occlusive group. Various relevant factors, including National Institute of Health Stroke Scale (NIHSS) scores, type of antithrombotic therapy, stroke progression in the first week, and transcranial Doppler (TCD) flow-waveforms (in the occlusive subgroup) were analysed. Favourable outcomes were defined as a 1-year modified Rankin-Scale score of 0–1. Favourable anatomical outcomes were defined as a reversal of dissection-associated stenosis during follow-up.

Results

The aneurysm and stenotic groups showed favourable outcomes, while the occlusive group outcomes were less favourable. In the stenotic group, anticoagulation, an NIHSS score ≥4, and stroke progression were inversely associated with favourable long-term outcomes. Remarkably, in the occlusive group, flow abnormality more severe than minimal flow was associated with stroke progression, unfavourable long-term outcome, and arterial irreversibility.

Conclusions

The outcome of sCAD depends on its radiological subtype. In the occlusive subtype, which is associated with the worst outcome, TCD flow analysis may predict acute stroke progression and long-term outcome.

Key Points

• Outcomes in cervical artery dissection may be determined by radiological subtypes.

• The aneurysm and stenotic groups had favourable outcomes.

• The occlusive group had less favourable functional outcomes.

• Flow-waveform analysis by TCD could predict functional and anatomical outcomes.

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Title: Prognosis of spontaneous cervical artery dissection and transcranial Doppler findings associated with clinical outcomes
Authors: Woo-Jin Lee
Keun-Hwa Jung
Jangsup Moon
Soon-Tae Lee
Kon Chu
Sang-Kun Lee
Jae-Kyu Roh
Publication date: 01-05-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 5/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3944-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Prognosis of spontaneous cervical artery dissection and transcranial Doppler findings associated with clinical outcomes

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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