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European Radiology
Published in: European Radiology 3/2016

01-03-2016 | Gastrointestinal

Pancreatic adenocarcinomas without secondary signs on multiphasic multidetector CT: association with clinical and histopathologic features

Authors: Tsutomu Tamada, Katsuyoshi Ito, Naoki Kanomata, Teruki Sone, Akihiko Kanki, Atsushi Higaki, Minoru Hayashida, Akira Yamamoto

Published in: European Radiology | Issue 3/2016

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Abstract

Purpose

To determine the clinical, histopathologic and imaging features of pancreatic adenocarcinomas without secondary signs on dynamic CT.

Materials and Methods

Seventy patients (mean age 70 years) with histologically proven pancreatic adenocarcinoma underwent preoperative contrast material-enhanced multiphasic multidetector CT before pancreatic resection. In each patient, clinical data including carbohydrate antigen 19–9, frequency of isoattenuating tumours, and presence of secondary signs and histopathologic findings such as tumour location, tumour stage, and microscopic infiltrative growth grade were evaluated.

Results

Ten tumours (14 %) were without secondary signs, and 60 (86 %) were with secondary signs. Tumours without and with secondary signs were located in the uncinate process in 5 (50 %) and 3 (5 %), head in 3 (30 %) and 29 (48 %), body in 2 (20 %) and 22 (37 %), and tail in 0 (0 %) and 6 (10 %), respectively (p = .001). The frequency of isoattenuating pancreatic adenocarcinomas without secondary signs was significantly higher than those with secondary signs (p = 0.034). The tumour stage of pancreatic adenocarcinomas without secondary signs was earlier than that in tumours with secondary signs (p = 0.041).

Conclusions

Pancreatic adenocarcinomas without secondary signs is characterized by the presence of uncinate and isoattenuating tumours and earlier tumour stage compared to tumours with secondary signs.

Key Points

• Frequency of pancreatic adenocarcinomas without secondary signs on multiphasic CT is 14 %.
• Pancreatic adenocarcinomas without secondary signs are common in the uncinate process.
• Pancreatic adenocarcinomas without secondary signs are common in isoattenuating tumours.
• Pancreatic adenocarcinomas without secondary signs are characterized by earlier-stage tumours.
Literature
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Metadata
Title
Pancreatic adenocarcinomas without secondary signs on multiphasic multidetector CT: association with clinical and histopathologic features
Authors
Tsutomu Tamada
Katsuyoshi Ito
Naoki Kanomata
Teruki Sone
Akihiko Kanki
Atsushi Higaki
Minoru Hayashida
Akira Yamamoto
Publication date
01-03-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3880-3

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