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European Radiology
Published in: European Radiology 1/2016

01-01-2016 | Chest

CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer

Authors: Stefania Rizzo, Francesco Petrella, Valentina Buscarino, Federica De Maria, Sara Raimondi, Massimo Barberis, Caterina Fumagalli, Gianluca Spitaleri, Cristiano Rampinelli, Filippo De Marinis, Lorenzo Spaggiari, Massimo Bellomi

Published in: European Radiology | Issue 1/2016

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Abstract

Objectives

To assess the association between CT features and EGFR, ALK, KRAS mutations in non-small cell lung cancer.

Methods

Patients undergoing chest CT and testing for the above gene mutations were included. Qualitative evaluation of CTs included: lobe; lesion diameter; shape; margins; ground-glass opacity; density; cavitation; air bronchogram; pleural thickening; intratumoral necrosis; nodules in tumour lobe; nodules in non-tumour lobes; pleural retraction; location; calcifications; emphysema; fibrosis; pleural contact; pleural effusion. Statistical analysis was performed to assess association of features with each gene mutation. ROC curves for gene mutations were drawn; the corresponding area under the curve was calculated. P-values <0.05 were considered significant.

Results

Of 285 patients, 60/280 (21.43 %) were positive for EGFR mutation; 31/270 (11.48 %) for ALK rearrangement; 64/240 (26.67 %) for KRAS mutation. EGFR mutation was associated with air bronchogram, pleural retraction, females, non-smokers, small lesion size, and absence of fibrosis. ALK rearrangements were associated with age and pleural effusion. KRAS mutation was associated with round shape, nodules in non-tumour lobes, and smoking.

Conclusions

This study disclosed associations between CT features and alterations of EGFR (air bronchogram, pleural retraction, small lesion size, absence of fibrosis), ALK (pleural effusion) and KRAS (round lesion shape, nodules in non-tumour lobes).

Key Points

• Air bronchogram, pleural retraction, small size relate to EGFR mutation in NSCLC.
• Pleural effusion and younger age relate to ALK mutation.
• Round lesion shape, nodules in non-tumour lobes relate to KRAS mutation.
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Metadata
Title
CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer
Authors
Stefania Rizzo
Francesco Petrella
Valentina Buscarino
Federica De Maria
Sara Raimondi
Massimo Barberis
Caterina Fumagalli
Gianluca Spitaleri
Cristiano Rampinelli
Filippo De Marinis
Lorenzo Spaggiari
Massimo Bellomi
Publication date
01-01-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3814-0

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