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European Radiology
Published in: European Radiology 4/2010

01-04-2010 | Urogenital

Diffusion-weighted MR imaging of kidneys in patients with chronic kidney disease: initial study

Authors: Xueqin Xu, Wenqiang Fang, Huawei Ling, Weimin Chai, Kemin Chen

Published in: European Radiology | Issue 4/2010

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Abstract

Objective

To prospectively evaluate the feasibility of diffusion-weighted (DW) magnetic resonance (MR) imaging in the assessment of renal function in patients with chronic kidney disease (CKD).

Methods

Seventy-two healthy volunteers and 43 patients underwent coronal echo-planar DW MR imaging of the kidneys with a single breath-hold time of 16 s. The patients were grouped according to five stages as indicated by the K/DOQI CKD (kidney disease outcome quality initiative). The apparent diffusion coefficient (ADC) value of the kidneys was calculated with high b values (b = 500 s/mm2). The ADC values were compared between patients and healthy volunteers, and among different stages. For statistical analysis, Student’s t tests, ANOVA, Pearson’s correlation tests, and Spearman’s correlation tests were used.

Results

No difference between the cortex and medulla could be observed on DW images of all volunteers. Patients with CKD had significantly lower renal ADC (t = −4.383, P = 0.000) than volunteers. The ADC values of kidneys were significantly lower than normal at most stages of CKD, except CKD1. There was a negative correlation between the ADCs and serum creatinine (sCr) level (P = 0.000) amongst the patients.

Conclusion

Diffusion-weighted MR imaging is feasible in the assessment of renal function, especially in the detection of early stage renal failure of CKD.
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Metadata
Title
Diffusion-weighted MR imaging of kidneys in patients with chronic kidney disease: initial study
Authors
Xueqin Xu
Wenqiang Fang
Huawei Ling
Weimin Chai
Kemin Chen
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 4/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-009-1619-8

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