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01-09-2014 | Musculoskeletal

Test-retest reliability of automated whole body and compartmental muscle volume measurements on a wide bore 3T MR system

Authors: Marianna S. Thomas, David Newman, Olof Dahlqvist Leinhard, Bahman Kasmai, Richard Greenwood, Paul N. Malcolm, Anette Karlsson, Johannes Rosander, Magnus Borga, Andoni P. Toms

Published in: European Radiology | Issue 9/2014

Abstract

Purpose

To measure the test-retest reproducibility of an automated system for quantifying whole body and compartmental muscle volumes using wide bore 3 T MRI.

Materials and methods

Thirty volunteers stratified by body mass index underwent whole body 3 T MRI, two-point Dixon sequences, on two separate occasions. Water-fat separation was performed, with automated segmentation of whole body, torso, upper and lower leg volumes, and manually segmented lower leg muscle volumes.

Results

Mean automated total body muscle volume was 19·32 L (SD9·1) and 19·28 L (SD9·12) for first and second acquisitions (Intraclass correlation coefficient (ICC) = 1·0, 95 % level of agreement -0·32–0·2 L). ICC for all automated test-retest muscle volumes were almost perfect (0·99–1·0) with 95 % levels of agreement 1.8–6.6 % of mean volume. Automated muscle volume measurements correlate closely with manual quantification (right lower leg: manual 1·68 L (2SD0·6) compared to automated 1·64 L (2SD 0·6), left lower leg: manual 1·69 L (2SD 0·64) compared to automated 1·63 L (SD0·61), correlation coefficients for automated and manual segmentation were 0·94–0·96).

Conclusion

Fully automated whole body and compartmental muscle volume quantification can be achieved rapidly on a 3 T wide bore system with very low margins of error, excellent test-retest reliability and excellent correlation to manual segmentation in the lower leg.

Key Points

• Sarcopaenia is an important reversible complication of a number of diseases.

• Manual quantification of muscle volume is time-consuming and expensive.

• Muscles can be imaged using in and out of phase MRI.

• Automated atlas-based segmentation can identify muscle groups.

• Automated muscle volume segmentation is reproducible and can replace manual measurements.

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Title: Test-retest reliability of automated whole body and compartmental muscle volume measurements on a wide bore 3T MR system
Authors: Marianna S. Thomas
David Newman
Olof Dahlqvist Leinhard
Bahman Kasmai
Richard Greenwood
Paul N. Malcolm
Anette Karlsson
Johannes Rosander
Magnus Borga
Andoni P. Toms
Publication date: 01-09-2014
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 9/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3226-6

ACC 2024 Congress

Springer Medicine

Test-retest reliability of automated whole body and compartmental muscle volume measurements on a wide bore 3T MR system

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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