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European Radiology

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Open Access 01-08-2014 | Head and Neck

Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

Authors: Shui-xing Zhang, Qian-jun Jia, Zhong-ping Zhang, Chang-hong Liang, Wen-bo Chen, Qian-hui Qiu, He Li

Published in: European Radiology | Issue 8/2014

Abstract

Objectives

We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC).

Methods

Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0–800 s/mm²). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids.

Results

IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P < 0.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P < 0.0001). However, the ADC was not significantly different between the two groups (P > 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05).

Conclusions

IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC.

Key Points

• Intravoxel incoherent motion (IVIM) analysis permits separate quantification of diffusion and perfusion.

• IVIM DWI is a feasible technique for investigating primary NPC.

• IVIM suggests that primary NPC tissue voxels exhibit both perfusion and diffusion.

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Title: Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
Authors: Shui-xing Zhang
Qian-jun Jia
Zhong-ping Zhang
Chang-hong Liang
Wen-bo Chen
Qian-hui Qiu
He Li
Publication date: 01-08-2014
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 8/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3203-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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