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European Radiology
Published in: European Radiology 6/2014

01-06-2014 | Magnetic Resonance

Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: initial experience

Authors: Chan Hong Moon, Alessandro Furlan, Jung-Hwan Kim, Tiejun Zhao, Ron Shapiro, Kyongtae Ty Bae

Published in: European Radiology | Issue 6/2014

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Abstract

Objectives

To compare sodium (23Na) characteristics between native and transplanted kidneys using dual-tuned proton (1H)/sodium MRI.

Methods

Six healthy volunteers and six renal transplant patients (3 normal function, 3 acute allograft rejection) were included. Proton/sodium MRI was obtained at 3 T using a dual-tuned coil. Signal to noise ratio (SNR), sodium concentration ([23Na]) and cortico-medullary sodium gradient (CMSG) were measured. Reproducibility of [23Na] measurement was also tested. SNR, [23Na] and CMSG of the native and transplanted kidneys were compared.

Results

Proton and sodium images of kidneys were successfully acquired. SNR and [23Na] measurements of the native kidneys were reproducible at two different sessions. [23Na] and CMSG of the transplanted kidneys was significantly lower than those of the native kidneys: 153.5 ± 11.9 vs. 192.9 ± 9.6 mM (P = 0.002) and 8.9 ± 1.5 vs. 10.5 ± 0.9 mM/mm (P = 0.041), respectively. [23Na] and CMSG of the transplanted kidneys with normal function vs. acute rejection were not statistically different.

Conclusions

Sodium quantification of kidneys was reliably performed using proton/sodium MRI. [23Na] and CMSG of the transplanted kidneys were lower than those of the native kidneys, but without a statistically significant difference between patients with or without renal allograft rejection.

Key Points

• Dual-tuned proton/sodium RF coil enables co-registered proton and sodium MRI.
• Structural and sodium biochemical property can be acquired by dual-tuned proton/sodium MRI.
• Sodium and sodium gradient of kidneys can be measured by dual-tuned MRI.
• Sodium concentration was lower in transplanted kidneys than in native kidneys.
• Sodium gradient of transplanted kidneys was lower than for native kidneys.
Appendix
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Literature
1.
Chandarana H, Lee VS (2009) Renal functional MRI: are we ready for clinical application? Am J Roentgenol 192:1550–1557CrossRef
2.
Jamison R, Kriz W (1982) Urinary concentrating mechanism, structure and function. Oxford University Press, New York
3.
4.
Haneder S, Juras V, Michaely H et al (2013) In vivo sodium (23Na) imaging of the human kidneys at 7T: preliminary results. Eur Radiol 24:494–501PubMedCrossRef
5.
Haneder S, Kettnaker P, Konstandin S et al (2013) Quantitative in vivo 23Na MR imaging of the healthy human kidney: determination of physiological ranges at 3.0T with comparison to DWI and BOLD. MAGMA 26:501–509PubMedCrossRef
6.
Haneder S, Konstandin S, Morelli J et al (2011) Quantitative and qualitative (23)Na MR imaging of the human kidneys at 3T: before and after a water load. Radiology 260:857–865PubMedCrossRef
7.
Haneder S, Michaely H, Konstandin S et al (2014) 3T renal (23)Na-MRI: effects of desmopressin in patients with central diabetes insipidus. MAGMA 27:47–52
8.
Maril N, Margalit R, Mispelter J, Degani H (2004) Functional sodium magnetic resonance imaging of the intact rat kidney. Kidney Int 65:927–935PubMedCrossRef
9.
Maril N, Margalit R, Mispelter J, Degani H (2005) Sodium magnetic resonance imaging of diuresis: spatial and kinetic response. Magn Reson Med 53:545–552PubMedCrossRef
10.
Maril N, Margalit R, Rosen S, Heyman SN, Degani H (2006) Detection of evolving acute tubular necrosis with renal 23Na MRI: studies in rats. Kidney Int 69:765–768PubMedCrossRef
11.
Maril N, Rosen Y, Reynolds GH, Ivanishev A, Ngo L, Lenkinski RE (2006) Sodium MRI of the human kidney at 3 tesla. Magn Reson Med 56:1229–1234PubMedCrossRef
12.
Kalayciyan R, Wetterling F, Neudecker S, Haneder S, Gretz N, Schad L (2013) Bilateral kidney sodium-MRI: enabling accurate quantification of renal sodium concentration through a two-element phased array system. J Magn Res Imaging 38:564–572CrossRef
13.
14.
Atthe B, Babsky A, Hopewell P, Phillips C, Molitoris B, Bansal N (2009) Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI. Am J Physiol Ren Physiol 297:F1288–F1298CrossRef
15.
Neuberger T, Gulani V, Webb A (2007) Sodium renal imaging in mice at high magnetic fields. Magn Reson Med 58:1067–1071PubMedCrossRef
16.
Moon CH, Furlan A, Kim J-H, Jacobs L, Zhao T, Bae KT (2011) In vivo sodium MR imaging of rabbit kidney using dual-tuned RF coil at 3T. Proc Int Soc Magn Reson Med 19:2946
17.
Shapiro EM, Borthakur A, Gougoutas A, Reddy R (2002) 23Na MRI accurately measures fixed charge density in articular cartilage. Magn Reson Med 47:284–291PubMedCentralPubMedCrossRef
18.
Moon CH, Kim J-H, Zhao T (2013) Quantitative 23Na MRI of human knee cartilage using dual‐tuned 1H/23Na transceiver array radiofrequency coil at 7 tesla. J Magn Reson Imaging 38:1063–1072PubMedCrossRef
19.
Kim J-H, Moon CH, Park B-W, Furlan A, Zhao T, Bae K (2012) Multichannel transceiver dual-tuned RF coil for proton/sodium MR imaging of knee cartilage at 3T. Magn Reson Imaging 30:562–571PubMedCrossRef
20.
Moon CH, Jacobs L, Kim JH et al (2012) Part 2: quantitative proton T2 and sodium magnetic resonance imaging to assess intervertebral disc degeneration in a rabbit model. Spine 37:E1113–E1119PubMedCentralPubMedCrossRef
21.
Moon CH, Kim JH, Jacobs L et al (2012) Part 1: dual-tuned proton/sodium magnetic resonance imaging of the lumbar spine in a rabbit model. Spine 37:E1106–E1112PubMedCentralPubMedCrossRef
22.
Boada FE, Gillen JS, Shen GX, Chang SY, Thulborn KR (1997) Fast three dimensional sodium imaging. Magn Reson Med 37:706–715PubMedCrossRef
23.
Jerecic R, Bock M, Nielles-Vallespin S, Wacker C, Bauer W, Schad LR (2004) ECG-gated 23Na-MRI of the human heart using a 3D-radial projection technique with ultra-short echo times. MAGMA 16:297–302PubMedCrossRef
24.
Nielles-Vallespin S, Weber MA, Bock M et al (2007) 3D radial projection technique with ultrashort echo times for sodium MRI: clinical applications in human brain and skeletal muscle. Magn Reson Med 57:74–81PubMedCrossRef
25.
Staroswiecki E, Bangerter NK, Gurney PT, Grafendorfer T, Gold GE, Hargreaves BA (2010) In vivo sodium imaging of human patellar cartilage with a 3D cones sequence at 3T and 7T. J Magn Reson Imaging 32:446–451PubMedCentralPubMedCrossRef
26.
Zhao T, Qian Y, Hue Y, Ibrahim T, Boad F (2009) Implementation of a 3D isotropic ultra-short TE (UTE) sequence. Proc Int Soc Magn Reson Med 17:2662
27.
Sadowski EA, Fain SB, Alford SK et al (2005) Assessment of acute renal transplant rejection with blood oxygen level–dependent MR imaging: initial experience. Radiology 236:911–919PubMedCrossRef
28.
Thoeny HC, Zumstein D, Simon-Zoula S et al (2006) Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology 241:812–821PubMedCrossRef
29.
Chang G, Madelin G, Sherman O et al (2012) Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: preliminary results. Eur Radiol 22:1341–1349PubMedCentralPubMedCrossRef
Metadata
Title
Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: initial experience
Authors
Chan Hong Moon
Alessandro Furlan
Jung-Hwan Kim
Tiejun Zhao
Ron Shapiro
Kyongtae Ty Bae
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3138-5

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