Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 6/2012

01-06-2012 | Musculoskeletal

Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: preliminary results

Authors: Gregory Chang, Guillaume Madelin, Orrin H. Sherman, Eric J. Strauss, Ding Xia, Michael P. Recht, Alexej Jerschow, Ravinder R. Regatte

Published in: European Radiology | Issue 6/2012

Login to get access

Abstract

Objectives

To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) 23Na MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T).

Methods

This study had institutional review board approval. We recruited 11 consecutive patients (41.5 ± 11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median = 26 weeks) with 7-T MRI using: proton-T2 (TR/TE = 3,000 ms/60 ms); sodium UTE (TR/TE = 100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na+]R), adjacent native cartilage ([Na+]N), and native cartilage within the opposite, non-surgical compartment ([Na+]N2) were calculated using external NaCl phantoms.

Results

For conventional sodium imaging, mean [Na+]R, [Na+]N, [Na+]N2 were 177.8 ± 54.1 mM, 170.1 ± 40.7 mM, 172.2 ± 30 mM respectively. Differences in [Na+]R versus [Na+]N (P = 0.59) and [Na+]N versus [Na+]N2 (P = 0.89) were not significant. For sodium IR imaging, mean [Na+]R, [Na+]N, [Na+]N2 were 108.9 ± 29.8 mM, 204.6 ± 34.7 mM, 249.9 ± 44.6 mM respectively. Decreases in [Na+]R versus [Na+]N (P = 0.0.0000035) and [Na+]N versus [Na+]N2 (P = 0.015) were significant.

Conclusions

Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na+] within cartilage repair and native tissue.

Key Points

• NaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid.
• NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone.
• This may facilitate more accurate assessment of repair tissue composition and quality.
Literature
1.
2.
Trattnig S, Domayer S, Welsch GW, Mosher T, Eckstein F (2009) MR imaging of cartilage and its repair in the knee – a review. Eur Radiol 19:1582–1594PubMedCrossRef
3.
Marlovits S, Striessnig G, Resinger CT et al (2004) Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging. Eur J Radiol 52:310–319PubMedCrossRef
4.
Potter HG, Foo LF (2006) Magnetic resonance imaging of articular cartilage: trauma, degeneration, and repair. Am J Sports Med 34:661–677PubMedCrossRef
5.
Trattnig S, Mamisch TC, Welsch GH et al (2007) Quantitative T2 mapping of matrix-associated autologous chondrocyte transplantation at 3 Tesla: an in vivo cross-sectional study. Invest Radiol 42:442–448PubMedCrossRef
6.
Trattnig S, Mamisch TC, Pinker K et al (2008) Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla. Eur Radiol 18:1251–1259PubMedCrossRef
7.
White LM, Sussman MS, Hurtig M, Probyn L, Tomlinson G, Kandel R (2006) Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects. Radiology 241:407–414PubMedCrossRef
8.
Trattnig S, Welsch GH, Juras V et al (2010) 23Na MR imaging at 7 T after knee matrix-associated autologous chondrocyte transplantation preliminary results. Radiology 257:175–184PubMedCrossRef
9.
Schmitt B, Zbyn S, Stelzeneder D et al (2011) Cartilage quality assessment by using glycosaminoglycan chemical exchange saturation transfer and 23Na MR imaging at 7 T. Radiology 260:257–264PubMedCrossRef
10.
Trattnig S, Marlovits S, Gebetsroither S et al (2007) Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3.0 T: preliminary results. J Magn Reson Imaging 26:974–982PubMedCrossRef
11.
Mosher TJ, Dardzinski BJ (2004) Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol 8:355–368PubMedCrossRef
12.
Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland JB, Reddy R (2006) Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed 19:781–821PubMedCrossRef
13.
Li X, Benjamin Ma C, Link TM et al (2007) In vivo T(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthr Cart 15:789–797CrossRef
14.
Burstein D, Gray M, Mosher T, Dardzinski B (2009) Measures of molecular composition and structure in osteoarthritis. Radiol Clin North Am 47:675–686PubMedCrossRef
15.
Ling W, Regatte RR, Navon G, Jerschow A (2008) Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci USA 105:2266–2270PubMedCrossRef
16.
Wang L, Wu Y, Chang G et al (2009) Rapid isotropic 3D-sodium MRI of the knee joint in vivo at 7 T. J Magn Reson Imaging 30:606–614PubMedCrossRef
17.
Staroswiecki E, Bangerter NK, Gurney PT, Grafendorfer T, Gold GE, Hargreaves BA (2010) In vivo sodium imaging of human patellar cartilage with a 3D cones sequence at 3 T and 7 T. J Magn Reson Imaging 32:446–451PubMedCrossRef
18.
Wheaton AJ, Borthakur A, Shapiro EM et al (2004) Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging – feasibility study. Radiology 231:900–905PubMedCrossRef
19.
Madelin G, Lee JS, Inati S, Jerschow A, Regatte RR (2010) Sodium inversion recovery MRI of the knee joint in vivo at 7 T. J Magn Reson 207:42–52PubMedCrossRef
20.
Stobbe R, Beaulieu C (2005) In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation. Magn Reson Med 54:1305–1310PubMedCrossRef
21.
Marlovits S, Singer P, Zeller P, Mandl I, Haller J, Trattnig S (2006) Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol 57:16–23PubMedCrossRef
22.
23.
Shapiro EM, Borthakur A, Kaufman JH, Leigh JS, Reddy R (2001) Water distribution patterns inside bovine articular cartilage as visualized by 1H magnetic resonance imaging. Osteoarthr Cart 9:533–538CrossRef
24.
Borthakur A, Shapiro EM, Akella SV, Gougoutas A, Kneeland JB, Reddy R (2002) Quantifying sodium in the human wrist in vivo by using MR imaging. Radiology 224:598–602PubMedCrossRef
25.
Kuettner KE (1992) Biochemistry of articular cartilage in health and disease. Clin Biochem 25:155–163PubMedCrossRef
26.
Madelin G, Babb JS, Xia D, Chang G, Jerschow A, Regatte RR (2011) Reproducibility and repeatibility of quantitative sodium MRI in vivo in articular cartilage at 3 T and 7 T. Magn Reson Med. doi:10.​1002/​mrm.​23307
27.
Glaser C, Mendlik T, Dinges J et al (2006) Global and regional reproducibility of T2 relaxation time measurements in human patellar cartilage. Magn Reson Med 56:527–534PubMedCrossRef
28.
Mosher TJ, Zhang Z, Reddy R et al (2011) Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 multicenter trial. Radiology 258:832–842PubMedCrossRef
29.
Welsch GH, Apprich S, Zbyn S et al (2010) Biochemical (T2, T2* and magnetisation transfer ratio) MRI of knee cartilage: feasibility at ultra-high field (7 T) compared with high field (3 T) strength. Eur Radiol
30.
DiMicco MA, Patwari P, Siparsky PN et al (2004) Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum 50:840–848PubMedCrossRef
31.
Tochigi Y, Buckwalter JA, Martin JA et al (2011) Distribution and progression of chondrocyte damage in a whole-organ model of human ankle intra-articular fracture. J Bone Joint Surg Am 93:533–539PubMedCrossRef
32.
Bansal N, Szczepaniak L, Ternullo D, Fleckenstein JL, Malloy CR (2000) Effect of exercise on (23)Na MRI and relaxation characteristics of the human calf muscle. J Magn Reson Imaging 11:532–538PubMedCrossRef
Metadata
Title
Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: preliminary results
Authors
Gregory Chang
Guillaume Madelin
Orrin H. Sherman
Eric J. Strauss
Ding Xia
Michael P. Recht
Alexej Jerschow
Ravinder R. Regatte
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2383-8

Other articles of this Issue 6/2012

European Radiology 6/2012 Go to the issue

Gastrointestinal

Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis

Cardiac

Coronary artery assessment by multidetector computed tomography in patients with prosthetic heart valves

Cardiac

Prospective ECG triggering reduces prosthetic heart valve-induced artefacts compared with retrospective ECG gating on 256-slice CT

Magnetic Resonance

Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values

Interventional

CT-guided adrenal biopsy: comparison of ipsilateral decubitus versus prone patient positioning for biopsy approach

Ultrasound

Quantitative evaluation of contrast-enhanced ultrasound after intravenous administration of a microbubble contrast agent for differentiation of benign and malignant thyroid nodules: assessment of diagnostic accuracy