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01-09-2013 | Hepatobiliary-Pancreas

Contrast-enhanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-enhanced CT

Authors: Wei Wang, Li-Da Chen, Ming-De Lu, Guang-Jian Liu, Shun-Li Shen, Zuo-Feng Xu, Xiao-Yan Xie, Yan Wang, Lu-Yao Zhou

Published in: European Radiology | Issue 9/2013

Abstract

Objectives

To investigate and compare contrast-enhanced ultrasound (CEUS) in the characterisation of histologically proven focal nodular hyperplasia (FNH) with contrast-enhanced computed tomography (CECT).

Methods

CEUS was performed in 85 patients with 85 histologically proven FNHs. Enhancement, centrifugal filling, spoke-wheel arteries, feeding artery and central scarring were reviewed and correlated with lesion size or liver background. Independent factors for predicting FNH from other focal liver lesions (FLLs) were evaluated. Forty-seven FLLs with CECT were randomly selected for comparison of diagnostic performance with CEUS.

Results

Centrifugal filling was more common (P = 0.002) and the significant predictor (P = 0.003) in FNHs ≤3 cm. Lesion size or liver background has no significant influence on the detection rate of the spoke-wheel arteries and feeding artery (P > 0.05). Central scarring was found in 42.6 % of FNHs ≥3 cm (P = 0.000). The area under the ROC curve, sensitivity and specificity showed no significant differences between CEUS and CECT (P > 0.05), except that the sensitivity of CEUS was better for reader 1 (P = 0.041).

Conclusion

CEUS is valuable in characterising centrifugal filling signs or spoke wheels in small FNHs and should be employed as the first-line imaging technique for diagnosis of FNH.

Key Points

• The confident diagnosis of focal nodular hyperplasia is important in liver imaging.

• The centrifugal filling sign is useful for diagnosis of FNHs ≤3 cm.

• Contrast-enhanced ultrasound and contrast-enhanced CT have similar diagnostic performance for FNH.

• CEUS should be the first-line imaging technique for the diagnosis of FNH.

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Title: Contrast-enhanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-enhanced CT
Authors: Wei Wang
Li-Da Chen
Ming-De Lu
Guang-Jian Liu
Shun-Li Shen
Zuo-Feng Xu
Xiao-Yan Xie
Yan Wang
Lu-Yao Zhou
Publication date: 01-09-2013
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 9/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-013-2849-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Contrast-enhanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-enhanced CT

Abstract

Objectives

Methods

Results

Conclusion

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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