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European Radiology
Published in: European Radiology 4/2013

01-04-2013 | Pediatric

Reliability and responsiveness of the Juvenile Arthritis MRI Scoring (JAMRIS) system for the knee

Authors: Robert Hemke, Marion A. J. van Rossum, Mira van Veenendaal, Maaike P. Terra, Eline E. Deurloo, Milko C. de Jonge, J. Merlijn van den Berg, Koert M. Dolman, Taco W. Kuijpers, Mario Maas

Published in: European Radiology | Issue 4/2013

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Abstract

Objectives

To assess the reliability and responsiveness of a new Juvenile Arthritis MRI Scoring (JAMRIS) system for evaluating disease activity of the knee.

Methods

Twenty-five juvenile idiopathic arthritis (JIA) patients with clinical knee involvement were studied using open-bore 1-T MRI. MRI features of synovial hypertrophy, bone marrow changes, cartilage lesions and bone erosions were independently scored by five readers using the JAMRIS system. In addition, the JAMRIS system was determined to be a follow-up parameter by two readers to evaluate the response to therapy in 15 consecutive JIA patients.

Results

Inter-reader (ICCs 0.86–0.95) and intra-reader reliability (ICCs 0.92–1.00) for the scoring of JAMRIS features was good. Reliability of the actual scores and changes in scores over time was good for all items: ICCs 0.89–1.00, 0.87–1.00, respectively. Concerning therapy response, the mean synovial hypertrophy scores decreased significantly (mean 1.1 point; P < 0.001, SRM = −0.65). No change was observed with respect to bone marrow change, cartilage lesion and bone erosion scores.

Conclusions

The JAMRIS proved to be a simple and highly reliable assessment score in the evaluation of JIA disease activity of the knee. The JAMRIS system may serve as an objective and accurate outcome measure in future research and clinical trials.

Key Points

• MRI is increasingly used to diagnose and assess juvenile idiopathic arthritis.
• A simple and reliable scoring method would help monitor progress and research.
• The Juvenile Arthritis MRI Scoring (JAMRIS) system provides reliable objective measures.
• JAMRIS evaluates synovial hypertrophy, bone marrow changes, cartilage lesions and bone erosions.
• The JAMRIS system can detect therapeutic response and should help future research.
Appendix
Available only for authorised users
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Metadata
Title
Reliability and responsiveness of the Juvenile Arthritis MRI Scoring (JAMRIS) system for the knee
Authors
Robert Hemke
Marion A. J. van Rossum
Mira van Veenendaal
Maaike P. Terra
Eline E. Deurloo
Milko C. de Jonge
J. Merlijn van den Berg
Koert M. Dolman
Taco W. Kuijpers
Mario Maas
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
European Radiology / Issue 4/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2684-y

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