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01-02-2013 | Neuro

Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging

Authors: Tomokazu Nishiguchi, Takeshi Iwakiri, Kohji Hayasaki, Masahiko Ohsawa, Tetuya Yoneda, Yutaka Mitsuhashi, Akimasa Nishio, Vincent Dousset, Yukio Miki

Published in: European Radiology | Issue 2/2013

Abstract

Purpose

To investigate imaging characteristics of post-embolised meningioma and to determine if SW imaging can delineate tumour ischaemia.

Materials and methods

Sixteen patients were studied before and after preoperative embolisation therapy (8 histopathologically determined with ischaemia, 8 with non-ischaemia). In each patient, a slice-wise ROI for the entire tumour was established, and histogram variables (mean, SD, minimum, maximum, histogram width, mode, and peak height) of SW, ADC, CBV, CBF, MTT, and TTP maps were compared between ischaemic and non-ischaemic groups. Changes in SW histogram were correlated with histopathological characteristics.

Results

Signal intensity on the SW map tended to decrease in the ischaemic group and partially increased in the non-ischaemic group. A similar trend was observed on the ADC map. The PW histogram showed an MTT increase in ischaemic group; however, CBV did not show significant changes between ischaemic and non-ischaemic groups. Microhaemorrhage was slightly correlated with Δpeak height in the SW histogram.

Conclusion

Post-embolisation changes of intrinsic T2*-weighted MR contrasts on SW map are most likely associated with alterations in deoxyhaemoglobin levels and arterial blood flow.

Key Points

• Endovascular embolisation is now accepted as an adjuvant therapy for intracranial meningioma.

• Magnetic resonance imaging is used to assess the effects of embolisation.

• Unenhanced susceptibility-weighted MRI can delineate ischaemic and non-ischaemic areas.

• Signal changes at SW imaging are associated with diffusion and perfusion abnormalities.

• Three-dimensional high-resolution SW imaging offers a new imaging biomarker in assessing ischaemia.

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Title: Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging
Authors: Tomokazu Nishiguchi
Takeshi Iwakiri
Kohji Hayasaki
Masahiko Ohsawa
Tetuya Yoneda
Yutaka Mitsuhashi
Akimasa Nishio
Vincent Dousset
Yukio Miki
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: European Radiology / Issue 2/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2618-8

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Springer Medicine

Post-embolisation susceptibility changes in giant meningiomas: multiparametric histogram analysis using non-contrast-enhanced susceptibility-weighted PRESTO, diffusion-weighted and perfusion-weighted imaging

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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