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Published in: European Radiology 12/2012

01-12-2012 | Chest

Improved detection of focal pneumonia by chest radiography with bone suppression imaging

Authors: Feng Li, Roger Engelmann, Lorenzo Pesce, Samuel G. Armato III, Heber MacMahon

Published in: European Radiology | Issue 12/2012

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Abstract

Objective

To evaluate radiologists’ ability to detect focal pneumonia by use of standard chest radiographs alone compared with standard plus bone-suppressed chest radiographs.

Methods

Standard chest radiographs in 36 patients with 46 focal airspace opacities due to pneumonia (10 patients had bilateral opacities) and 20 patients without focal opacities were included in an observer study. A bone suppression image processing system was applied to the 56 radiographs to create corresponding bone suppression images. In the observer study, eight observers, including six attending radiologists and two radiology residents, indicated their confidence level regarding the presence of a focal opacity compatible with pneumonia for each lung, first by use of standard images, then with the addition of bone suppression images. Receiver operating characteristic (ROC) analysis was used to evaluate the observers’ performance.

Results

The mean value of the area under the ROC curve (AUC) for eight observers was significantly improved from 0.844 with use of standard images alone to 0.880 with standard plus bone suppression images (P < 0.001) based on 46 positive lungs and 66 negative lungs.

Conclusion

Use of bone suppression images improved radiologists’ performance for detection of focal pneumonia on chest radiographs.

Key Points

Bone suppression image processing can be applied to conventional digital radiography systems.
Bone suppression imaging (BSI) produces images that appear similar to dual-energy soft tissue images.
BSI improves the conspicuity of focal lung disease by minimizing bone opacity.
BSI can improve the accuracy of radiologists in detecting focal pneumonia.
Literature
2.
go back to reference Vilar J, Domingo ML, Soto C, Cogollos J (2004) Radiology of bacterial pneumonia. Eur J Radiol 51:102–113PubMedCrossRef Vilar J, Domingo ML, Soto C, Cogollos J (2004) Radiology of bacterial pneumonia. Eur J Radiol 51:102–113PubMedCrossRef
3.
go back to reference Trotman-Dickenson B (2003) Radiology in the intensive care unit (Part 1). J Intensiv Care Med 18:198–210CrossRef Trotman-Dickenson B (2003) Radiology in the intensive care unit (Part 1). J Intensiv Care Med 18:198–210CrossRef
4.
go back to reference Trotman-Dickenson B (2003) Radiology in the intensive care unit (Part 2). J Intensiv Care Med 18:239–252CrossRef Trotman-Dickenson B (2003) Radiology in the intensive care unit (Part 2). J Intensiv Care Med 18:239–252CrossRef
5.
go back to reference Schaefer-Prokop C, Neitzel U, Venema HW, Uffmann MU, Prokop M (2008) Digital chest radiography: an update on modern technology, dose containment and control of image quality. Eur Radiol 18:1818–1830PubMedCrossRef Schaefer-Prokop C, Neitzel U, Venema HW, Uffmann MU, Prokop M (2008) Digital chest radiography: an update on modern technology, dose containment and control of image quality. Eur Radiol 18:1818–1830PubMedCrossRef
6.
go back to reference MacMahon H, Li F, Engelmann R, Robeerts R, Armato S (2008) Dual-energy subtraction and temporal subtraction chest radiography. J Thorac Imaging 23:77–85PubMedCrossRef MacMahon H, Li F, Engelmann R, Robeerts R, Armato S (2008) Dual-energy subtraction and temporal subtraction chest radiography. J Thorac Imaging 23:77–85PubMedCrossRef
7.
go back to reference Armato SG III, Doshi DJ, Engelmann R, Caligiuri P, MacMahon H (2006) Temporal subtraction of dual-energy chest radiographs. Med Phys 33:1911–1919PubMedCrossRef Armato SG III, Doshi DJ, Engelmann R, Caligiuri P, MacMahon H (2006) Temporal subtraction of dual-energy chest radiographs. Med Phys 33:1911–1919PubMedCrossRef
8.
go back to reference Szucs-Farkas Z, Patak MA, Yuksel-Hatz S, Ruder T, Vock P (2008) Single-exposure dual-energy subtraction chest radiography: detection of pulmonary nodules and masses in clinical practice. Eur Radiol 18:24–31PubMedCrossRef Szucs-Farkas Z, Patak MA, Yuksel-Hatz S, Ruder T, Vock P (2008) Single-exposure dual-energy subtraction chest radiography: detection of pulmonary nodules and masses in clinical practice. Eur Radiol 18:24–31PubMedCrossRef
9.
go back to reference Kashani H, Varon CA, Paul NS et al (2010) Diagnostic performance of a prototype dual-energy chest imaging system: ROC analysis. Acad Radiol 17:298–308PubMedCrossRef Kashani H, Varon CA, Paul NS et al (2010) Diagnostic performance of a prototype dual-energy chest imaging system: ROC analysis. Acad Radiol 17:298–308PubMedCrossRef
10.
go back to reference Li F, Engelmann R, Doi K, MacMahon H (2008) Improved detection of small lung cancers with dual-energy subtraction chest radiography. AJR 190:886–891PubMedCrossRef Li F, Engelmann R, Doi K, MacMahon H (2008) Improved detection of small lung cancers with dual-energy subtraction chest radiography. AJR 190:886–891PubMedCrossRef
11.
go back to reference Tsubamoto M, Johkoh T, Kozuka T et al (2002) Temporal subtraction for the detection of hazy pulmonary opacities on chest radiography. AJR 179:467–471PubMed Tsubamoto M, Johkoh T, Kozuka T et al (2002) Temporal subtraction for the detection of hazy pulmonary opacities on chest radiography. AJR 179:467–471PubMed
12.
go back to reference Kakeda S, Nakamura K, Kamada K et al (2002) Improved detection of lung nodules by using a temporal subtraction technique. Radiology 224:145–151PubMedCrossRef Kakeda S, Nakamura K, Kamada K et al (2002) Improved detection of lung nodules by using a temporal subtraction technique. Radiology 224:145–151PubMedCrossRef
13.
go back to reference Loog M, Ginneken BV, Schilham AMR (2006) Filter learning: application to suppression of bony structures from chest radiographs. Med Image Anal 10:826–840PubMedCrossRef Loog M, Ginneken BV, Schilham AMR (2006) Filter learning: application to suppression of bony structures from chest radiographs. Med Image Anal 10:826–840PubMedCrossRef
14.
go back to reference Suzuki K, Abe H, MacMahon H, Doi K (2006) Image-processing technique for suppressing ribs in chest radiographs by means of massive training artificial neural network (MTANN). IEEE Trans Med Imaging 25:406–416PubMedCrossRef Suzuki K, Abe H, MacMahon H, Doi K (2006) Image-processing technique for suppressing ribs in chest radiographs by means of massive training artificial neural network (MTANN). IEEE Trans Med Imaging 25:406–416PubMedCrossRef
15.
go back to reference Oda S, Awai K, Suzuki K et al (2009) Performance of radiologists in detection of small pulmonary nodules on chest radiographs: effect of rib suppression with a massive-training artificial neural network. AJR 193:886–891CrossRef Oda S, Awai K, Suzuki K et al (2009) Performance of radiologists in detection of small pulmonary nodules on chest radiographs: effect of rib suppression with a massive-training artificial neural network. AJR 193:886–891CrossRef
16.
go back to reference Li F, Hara T, Shiraishi J, Engelmann R, MacMahon H, Doi K (2011) Improved detection of subtle lung nodules by use of chest radiographs with bone suppression imaging: ROC analysis with and without localization. AJR 196:W535–W541PubMedCrossRef Li F, Hara T, Shiraishi J, Engelmann R, MacMahon H, Doi K (2011) Improved detection of subtle lung nodules by use of chest radiographs with bone suppression imaging: ROC analysis with and without localization. AJR 196:W535–W541PubMedCrossRef
17.
go back to reference Li F, Engelmann R, Pesce L, Doi K, Metz CE, MacMahon H (2011) Improved detection of small lung cancers by use of bone suppression imaging: comparison with dual-energy subtraction chest radiographs. Radiology 261:937–949PubMedCrossRef Li F, Engelmann R, Pesce L, Doi K, Metz CE, MacMahon H (2011) Improved detection of small lung cancers by use of bone suppression imaging: comparison with dual-energy subtraction chest radiographs. Radiology 261:937–949PubMedCrossRef
18.
go back to reference Metz CE, Herman BA, Shen JH (1998) Maximum-likelihood estimation of receiver operating (ROC) curves from continuously distributed data. Stat Med 17:1033–1053PubMedCrossRef Metz CE, Herman BA, Shen JH (1998) Maximum-likelihood estimation of receiver operating (ROC) curves from continuously distributed data. Stat Med 17:1033–1053PubMedCrossRef
19.
go back to reference Dorfman DD, Berbaum KS, Metz CE (1992) ROC rating analysis: generalization to the population of readers and cases with the jackknife method. Invest Radiol 27:723–731PubMedCrossRef Dorfman DD, Berbaum KS, Metz CE (1992) ROC rating analysis: generalization to the population of readers and cases with the jackknife method. Invest Radiol 27:723–731PubMedCrossRef
20.
go back to reference Hillis SL, Berbaun KS, Metz CE (2008) Recent development in the Dorfman-Berbaum-Metz procedure for multireader ROC study analysis. Acad Radiol 15:647–661PubMedCrossRef Hillis SL, Berbaun KS, Metz CE (2008) Recent development in the Dorfman-Berbaum-Metz procedure for multireader ROC study analysis. Acad Radiol 15:647–661PubMedCrossRef
21.
go back to reference Starr SJ, Metz CE, Lusted LB, Goodenough DJ (1975) Visual detection and localization of radiographic images. Radiology 116:533–538PubMed Starr SJ, Metz CE, Lusted LB, Goodenough DJ (1975) Visual detection and localization of radiographic images. Radiology 116:533–538PubMed
22.
go back to reference Metz CE, Pan X (1999) “Proper” binormal ROC curves: theory and maximum-likelihood estimation. Math Psychol 43:1–33CrossRef Metz CE, Pan X (1999) “Proper” binormal ROC curves: theory and maximum-likelihood estimation. Math Psychol 43:1–33CrossRef
23.
go back to reference Young M, Marrie TJ (1994) Interobserver variability in the interpretation of chest roentgenograms of patients with possible pneumonia. Arch Intern Med 154:2729–2732PubMedCrossRef Young M, Marrie TJ (1994) Interobserver variability in the interpretation of chest roentgenograms of patients with possible pneumonia. Arch Intern Med 154:2729–2732PubMedCrossRef
24.
go back to reference Albaum MN, Hill LC, Murphy M et al (1996) Interobserver reliability of the chest radiograph in community-acquired pneumonia. Chest 110:343–350PubMedCrossRef Albaum MN, Hill LC, Murphy M et al (1996) Interobserver reliability of the chest radiograph in community-acquired pneumonia. Chest 110:343–350PubMedCrossRef
25.
go back to reference Ojutiku O, Haramati LB, Rakoff S, Sprayregen S (2005) Radiology residents’ on-call interpretation of chest radiographs for pneumonia. Acad Radiol 12:658–664PubMedCrossRef Ojutiku O, Haramati LB, Rakoff S, Sprayregen S (2005) Radiology residents’ on-call interpretation of chest radiographs for pneumonia. Acad Radiol 12:658–664PubMedCrossRef
26.
go back to reference Austin JHM, Romney BM, Goldsmith LS (1992) Missed bronchogenic carcinoma: radiographic findings in 27 patients with potentially resectable lesion evident in retrospect. Radiology 182:115–122PubMed Austin JHM, Romney BM, Goldsmith LS (1992) Missed bronchogenic carcinoma: radiographic findings in 27 patients with potentially resectable lesion evident in retrospect. Radiology 182:115–122PubMed
27.
go back to reference Monnier-cholley L, Carrat F, Cholley BP, Tubiana JM, Arrive L (2004) Detection of lung cancer on radiographs: receiver operating characteristic analysis of radiologists’, pulmonologists’ and anesthesiologists’ performance. Radiology 233:799–805PubMedCrossRef Monnier-cholley L, Carrat F, Cholley BP, Tubiana JM, Arrive L (2004) Detection of lung cancer on radiographs: receiver operating characteristic analysis of radiologists’, pulmonologists’ and anesthesiologists’ performance. Radiology 233:799–805PubMedCrossRef
28.
go back to reference Li F, Arimura H, Suzuki K et al (2005) Computer-aided diagnosis for detection of missed peripheral lung cancers on CT: ROC and LROC analysis. Radiology 237:684–690PubMedCrossRef Li F, Arimura H, Suzuki K et al (2005) Computer-aided diagnosis for detection of missed peripheral lung cancers on CT: ROC and LROC analysis. Radiology 237:684–690PubMedCrossRef
29.
go back to reference Shiraishi J, Pesce LL, Metz CE, Doi K (2009) On experimental design and data analysis in receiver operating characteristic (ROC) studies: lessons learned from papers published in RADIOLOGY from 1997 to 2006. Radiology 253:822–830PubMedCrossRef Shiraishi J, Pesce LL, Metz CE, Doi K (2009) On experimental design and data analysis in receiver operating characteristic (ROC) studies: lessons learned from papers published in RADIOLOGY from 1997 to 2006. Radiology 253:822–830PubMedCrossRef
Metadata
Title
Improved detection of focal pneumonia by chest radiography with bone suppression imaging
Authors
Feng Li
Roger Engelmann
Lorenzo Pesce
Samuel G. Armato III
Heber MacMahon
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
European Radiology / Issue 12/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2550-y

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