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01-01-2012 | Breast

Comparison of diffusion-weighted MR imaging and FDG PET/CT to predict pathological complete response to neoadjuvant chemotherapy in patients with breast cancer

Authors: Sang Hee Park, Woo Kyung Moon, Nariya Cho, Jung Min Chang, Seock-Ah Im, In Ae Park, Keon Wook Kang, Wonshik Han, Dong-Young Noh

Published in: European Radiology | Issue 1/2012

Abstract

Objective

To compare the use of diffusion-weighted MR imaging (DWI) and ¹⁸F-FDG PET/CT to predict pathological complete response (pCR) in breast cancer patients receiving neoadjuvant chemotherapy.

Methods

Thirty-four women with 34 invasive breast cancers underwent DWI and PET/CT before and after chemotherapy and before surgery. The percentage changes in the apparent diffusion coefficient (ADC) and the standardised uptake value (SUV) were calculated, and the diagnostic performances for predicting pCR were evaluated using receiver operating characteristic (ROC) curve analysis.

Results

After surgery, 7/34 patients (20.6%) were found to have pCR. A_z values for DWI, PET/CT and the combined use of DWI and PET/CT were 0.910, 0.873 and 0.944, respectively. The best cut-offs for differentiating pCR from non-pCR were a 54.9% increase in the ADC and a 63.9% decrease in the SUV. DWI showed 100% (7/7) sensitivity and 70.4% (19/27) specificity and PET/CT showed 100% sensitivity and 77.8% (21/27) specificity. When DWI and PET/CT were combined, there was a trend towards improved specificity compared with DWI.

Conclusions

DWI and FDG PET/CT show similar diagnostic accuracy for predicting pCR to neoadjuvant chemotherapy in breast cancer patients. The combined use of DWI and FDG PET/CT has the potential to improve specificity in predicting pCR.

Key Points

• DWI breast MR and PET/CT show similar accuracy for predicting pathological response

• The combined use of DWI and PET/CT can potentially improve specificity

• This can assist individualised treatment in breast cancer patients receiving neoadjvant chemotherapy

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Title: Comparison of diffusion-weighted MR imaging and FDG PET/CT to predict pathological complete response to neoadjuvant chemotherapy in patients with breast cancer
Authors: Sang Hee Park
Woo Kyung Moon
Nariya Cho
Jung Min Chang
Seock-Ah Im
In Ae Park
Keon Wook Kang
Wonshik Han
Dong-Young Noh
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 1/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2236-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparison of diffusion-weighted MR imaging and FDG PET/CT to predict pathological complete response to neoadjuvant chemotherapy in patients with breast cancer

Abstract

Objective

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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