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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 5/2011

Open Access 01-10-2011 | Research Article

Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT

Authors: Jing Gu, Pek-Lan Khong, Silun Wang, Queenie Chan, Wailun LAW, Jingbo Zhang

Published in: Molecular Imaging and Biology | Issue 5/2011

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Abstract

Purpose

The aim of the study was to assess correlations between parameters on diffusion-weighted imaging and 2-deoxy-2-[18F]fluoro-d-glucose–positron emission tomography/computed tomography (FDG-PET/CT) in rectal cancer.

Procedures

Thirty-three consecutive patients with pathologically confirmed rectal adenocarcinoma were included in this study. Apparent diffusion coefficient (ADC) maps were generated to calculate ADCmean (average ADC), ADCmin (lowest ADC), tumor volume, and total diffusivity index (TDI). PET/CT exams were performed within 1 week of magnetic resonance imaging. Standardized uptake values (SUVs) were normalized to the injected FDG dose and body weight. SUVmax (maximum SUV), SUVmean (average SUV), tumor volume, and total lesion glycolysis (TLG) were calculated using a 50% threshold.

Results

Significant negative correlations were found between ADCmin and SUVmax (r = −0.450, p = 0.009), and between ADCmean and SUVmean (r = −0.402, p = 0.020). A significant positive correlation was found between TDI and TLG (r = 0.634, p < 0.001).

Conclusion

The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma.
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Metadata
Title
Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT
Authors
Jing Gu
Pek-Lan Khong
Silun Wang
Queenie Chan
Wailun LAW
Jingbo Zhang
Publication date
01-10-2011
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 5/2011
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-010-0433-7

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