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European Radiology

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01-07-2011 | Breast

Normal parenchymal enhancement patterns in women undergoing MR screening of the breast

Authors: Sanaz A. Jansen, Vicky C. Lin, Maryellen L. Giger, Hui Li, Gregory S. Karczmar, Gillian M. Newstead

Published in: European Radiology | Issue 7/2011

Abstract

Objectives

To characterize the kinetic and morphological presentation of normal breast tissue on DCE-MRI in a large cohort of asymptomatic women, and to relate these characteristics to breast tissue density.

Methods

335 consecutive breast MR examinations in 229 asymptomatic women undergoing high-risk screening evaluations based on recommendations from the American Cancer Society including strong family history and genetic predisposition were selected for IRB-approved review (average age 49.2 ± 10.5 years). Breast tissue density was assessed on precontrast T₂-weighted images. Parenchymal enhancement pattern (PEP) was qualitatively classified as minimal, homogeneous, heterogeneous or nodular. Quantitative analysis of parenchymal enhancement kinetics (PEK) was performed, including calculation of initial and peak enhancement percentages (E ₁, E _peak), the time to peak enhancement (T _peak) and the signal enhancement ratio (SER).

Results

41.8% of examinations were classified as minimal, 13.7% homogeneous, 23.9% heterogeneous and 21.2% nodular PEP. Women with heterogeneously or extremely dense breasts exhibited a higher proportion of nodular PEP (44.2% (27/61)) and significantly higher E ₁, and E _peak (p < 0.003) compared with those with less dense breasts.

Conclusions

Qualitative and quantitative parenchymal enhancement characteristics vary by breast tissue density. In future work, the association between image-derived MR features of the normal breast and breast cancer risk should be explored.

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Title: Normal parenchymal enhancement patterns in women undergoing MR screening of the breast
Authors: Sanaz A. Jansen
Vicky C. Lin
Maryellen L. Giger
Hui Li
Gregory S. Karczmar
Gillian M. Newstead
Publication date: 01-07-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 7/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2080-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Normal parenchymal enhancement patterns in women undergoing MR screening of the breast

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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