Skip to main content
Top
Published in: European Radiology 3/2011

01-03-2011 | Editorial

Recent hot topics in contrast media

Author: Henrik S. Thomsen

Published in: European Radiology | Issue 3/2011

Login to get access

Abstract

This editorial reviews the way in which the facts related to the safety of iodinated and gadolinium based contrast agents have emerged over the last two decades. This is especially important given their ever increasing usage in modern computed tomographic (CT) and Magnetic resonance imaging (MRI) examinations. It also provides a very useful educational resume of this complex subject.
Literature
1.
go back to reference Thomsen HS, Archer JW, Schiermer L, Radensky PW (1998) The financial impact of Denmark’s decision to restrict the use of high-osmolar contrast media in intravascular radiographic procedures. Eur Radiol 8:321–322CrossRefPubMed Thomsen HS, Archer JW, Schiermer L, Radensky PW (1998) The financial impact of Denmark’s decision to restrict the use of high-osmolar contrast media in intravascular radiographic procedures. Eur Radiol 8:321–322CrossRefPubMed
2.
go back to reference Tepel M, van der Giet M, Schwartzfeld C et al (2000) Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343:180–184CrossRefPubMed Tepel M, van der Giet M, Schwartzfeld C et al (2000) Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 343:180–184CrossRefPubMed
3.
go back to reference Thomsen HS (2001) Contrast-medium-induced nephrotoxicity: are all answers in for Acetylcysteine? Eur Radiol 11:2351–2353CrossRefPubMed Thomsen HS (2001) Contrast-medium-induced nephrotoxicity: are all answers in for Acetylcysteine? Eur Radiol 11:2351–2353CrossRefPubMed
4.
go back to reference Ellis JH, Cohan RH (2009) Reducing the risk of contrast induced nephropathy. A perspective on the controversies. AJR Am J Roentgenol 192:1544–1549CrossRefPubMed Ellis JH, Cohan RH (2009) Reducing the risk of contrast induced nephropathy. A perspective on the controversies. AJR Am J Roentgenol 192:1544–1549CrossRefPubMed
5.
go back to reference Aspelin P, Aubry P, Fransson SG et al (2003) Nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med 348:491–499CrossRefPubMed Aspelin P, Aubry P, Fransson SG et al (2003) Nephrotoxic effects in high-risk patients undergoing angiography. N Engl J Med 348:491–499CrossRefPubMed
6.
go back to reference Laskey W, Aspelin P, Davidson C et al (2009) Nephrotoxicity of iodixanol versus iopamidol in patients with chroinic disease and diabetes undergoing coronary angiographic procedures. Am Heart J 158:822–828CrossRefPubMed Laskey W, Aspelin P, Davidson C et al (2009) Nephrotoxicity of iodixanol versus iopamidol in patients with chroinic disease and diabetes undergoing coronary angiographic procedures. Am Heart J 158:822–828CrossRefPubMed
7.
go back to reference Thomsen HS, Morcos SK (2006) Contrast-medium-induced nephropathy: is there a new consensus? A review of published guidelines. Eur Radiol 16:1835–1840 Thomsen HS, Morcos SK (2006) Contrast-medium-induced nephropathy: is there a new consensus? A review of published guidelines. Eur Radiol 16:1835–1840
8.
go back to reference Heinrich MC, Häberle L, Müller V et al (2009) Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials. Radiology 250:68–86CrossRefPubMed Heinrich MC, Häberle L, Müller V et al (2009) Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials. Radiology 250:68–86CrossRefPubMed
9.
go back to reference Reed M, Meier P, Tamhane UU et al (2009) The relative renal safety of iodixanol compared with low-osmolar contrast media: a meta-analysis of randomized controlled trials. JACC Cardiovasc Interv 2:645–654CrossRefPubMed Reed M, Meier P, Tamhane UU et al (2009) The relative renal safety of iodixanol compared with low-osmolar contrast media: a meta-analysis of randomized controlled trials. JACC Cardiovasc Interv 2:645–654CrossRefPubMed
10.
go back to reference Thomsen HS, Morcos SK (2008) Risk of contrast medium-induced nephropathy in high-risk patients undergoing MDCT—a pooled analysis of two randomized trials. Eur Radiol 18:891–897 Thomsen HS, Morcos SK (2008) Risk of contrast medium-induced nephropathy in high-risk patients undergoing MDCT—a pooled analysis of two randomized trials. Eur Radiol 18:891–897
11.
go back to reference Hoppe H, Spagnuolo S, Froehlich JM et al (2010) Retrospective analysis of patients for development of nephrogenic systemic fibrosis following conventional angiography using gadolinium-based contrast agents. Eur Radiol 20:595–603CrossRefPubMed Hoppe H, Spagnuolo S, Froehlich JM et al (2010) Retrospective analysis of patients for development of nephrogenic systemic fibrosis following conventional angiography using gadolinium-based contrast agents. Eur Radiol 20:595–603CrossRefPubMed
12.
go back to reference Thomsen HS, Almén T, Morcos SK et al (2002) Gadolinium-containing contrast media for radiographic examination: a position paper. Eur Radiol 12:2600–2605PubMed Thomsen HS, Almén T, Morcos SK et al (2002) Gadolinium-containing contrast media for radiographic examination: a position paper. Eur Radiol 12:2600–2605PubMed
13.
go back to reference Thomsen HS (2004) Gadolinium-based contrast media may be nephrotoxic even at approved doses (case report). Eur Radiol 14:1654–1656PubMed Thomsen HS (2004) Gadolinium-based contrast media may be nephrotoxic even at approved doses (case report). Eur Radiol 14:1654–1656PubMed
14.
go back to reference Elmståhl B, Nyman U, Leander P et al (2006) Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections. Eur Radiol 16:2712–2720CrossRefPubMed Elmståhl B, Nyman U, Leander P et al (2006) Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections. Eur Radiol 16:2712–2720CrossRefPubMed
15.
16.
go back to reference Thomsen HS (2006) Nephrogenic systemic fibrosis: a serious late adverse reaction to gadodiamide. Eur Radiol 16:2619–2621CrossRefPubMed Thomsen HS (2006) Nephrogenic systemic fibrosis: a serious late adverse reaction to gadodiamide. Eur Radiol 16:2619–2621CrossRefPubMed
17.
go back to reference Leiner T, Herborn C, Goyen M (2007) Nephrogenic systemic fibrosis is not exclusively associated with gadodiamide. Euro Radiol 17:1921–1923CrossRef Leiner T, Herborn C, Goyen M (2007) Nephrogenic systemic fibrosis is not exclusively associated with gadodiamide. Euro Radiol 17:1921–1923CrossRef
19.
go back to reference Evans CH, Drouven BJ (1983) The promotion of collagen polymerization by lanthanide and calcium ions. Biochem J 213:751–758PubMed Evans CH, Drouven BJ (1983) The promotion of collagen polymerization by lanthanide and calcium ions. Biochem J 213:751–758PubMed
20.
go back to reference Brouven BJ, Evans CK (1986) Collagen fibrillogenesis in the presence of lathanides. J Biol Chim 261:11792–11797 Brouven BJ, Evans CK (1986) Collagen fibrillogenesis in the presence of lathanides. J Biol Chim 261:11792–11797
21.
go back to reference SMRM workshop on contrast enhanced magnetic resonance (1991) Discussion. Magn Reson Med 22:229–232CrossRef SMRM workshop on contrast enhanced magnetic resonance (1991) Discussion. Magn Reson Med 22:229–232CrossRef
22.
go back to reference White GW, Gibby WA, Tweedle MF (2006) Comparison of Gd (DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy. Invest Radiol 41:272–8CrossRefPubMed White GW, Gibby WA, Tweedle MF (2006) Comparison of Gd (DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by inductively coupled plasma mass spectroscopy. Invest Radiol 41:272–8CrossRefPubMed
23.
go back to reference Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Gadolinium (III) chelates and MRI agents: Structure, dynamics and applications. Chem Rev 99:2293–2352 Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (1999) Gadolinium (III) chelates and MRI agents: Structure, dynamics and applications. Chem Rev 99:2293–2352
24.
go back to reference Wadas TJ, Sherman CD, Miner JH et al (2010) The biodistribution of [153Gd]Gd-labeled magnetic resonance contrast agents in a transgenic mouse model of renal failure differs greatly from control mice. Magn Reson Med 64(5):1274–80. doi:10.1002/mrm.22553 CrossRefPubMed Wadas TJ, Sherman CD, Miner JH et al (2010) The biodistribution of [153Gd]Gd-labeled magnetic resonance contrast agents in a transgenic mouse model of renal failure differs greatly from control mice. Magn Reson Med 64(5):1274–80. doi:10.​1002/​mrm.​22553 CrossRefPubMed
25.
go back to reference COMMISSION DECISION of 1.7.2010 concerning, in the framework of Article 31 of Directive 2001/83/EC of the European Parliament and of the Council, the marketing authorisations for Gadolinium-containing contrast agents for human use which contain one or more of the active substances “gadodiamide, gadopentetic acid, gadobenic acid, gadoxetic acid, gadoteridol, gadobutrol and gadoteric acid”. http://ec.europa.eu/health/documents/community-register/html/refh_others.htm . Accessed November 1st 2010 COMMISSION DECISION of 1.7.2010 concerning, in the framework of Article 31 of Directive 2001/83/EC of the European Parliament and of the Council, the marketing authorisations for Gadolinium-containing contrast agents for human use which contain one or more of the active substances “gadodiamide, gadopentetic acid, gadobenic acid, gadoxetic acid, gadoteridol, gadobutrol and gadoteric acid”. http://​ec.​europa.​eu/​health/​documents/​community-register/​html/​refh_​others.​htm . Accessed November 1st 2010
26.
go back to reference Böhm I, Schild HH (2006) A practical guide to diagnose lesser-known immediate and delayed contrast media-induced adverse cutaneous reactions. Eur Radiol 16:1570–1579CrossRefPubMed Böhm I, Schild HH (2006) A practical guide to diagnose lesser-known immediate and delayed contrast media-induced adverse cutaneous reactions. Eur Radiol 16:1570–1579CrossRefPubMed
27.
go back to reference Thomsen HS, Morcos SK (2004) Management of acute adverse reactions to contrast media. Eur Radiol 14:476–481CrossRefPubMed Thomsen HS, Morcos SK (2004) Management of acute adverse reactions to contrast media. Eur Radiol 14:476–481CrossRefPubMed
28.
go back to reference Morcos SK, Thomsen WJAW (2001) Prevention of generalized reactions to contrast media: a consensus report and guidelines. Eur Radiol 11:1720–1728CrossRefPubMed Morcos SK, Thomsen WJAW (2001) Prevention of generalized reactions to contrast media: a consensus report and guidelines. Eur Radiol 11:1720–1728CrossRefPubMed
29.
go back to reference Lightfoot CB, Abraham RJ, Mammen T (2009) Survey of radiologist’s knowledge regarding the management of severe contrast material-induced allergic reactions. Radiology 251:691–696CrossRefPubMed Lightfoot CB, Abraham RJ, Mammen T (2009) Survey of radiologist’s knowledge regarding the management of severe contrast material-induced allergic reactions. Radiology 251:691–696CrossRefPubMed
30.
go back to reference Munechika H, Hiramatsu Y, Kudo S et al (2003) A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography. Eur Radiol 13:185–194CrossRefPubMed Munechika H, Hiramatsu Y, Kudo S et al (2003) A prospective survey of delayed adverse reactions to iohexol in urography and computed tomography. Eur Radiol 13:185–194CrossRefPubMed
31.
go back to reference Webb JAW, Stacul F, Thomsen HS, Morcos SK (2003) Late reactions to intravascular iodinated contrast media. Eur Radiol 13:181–184CrossRefPubMed Webb JAW, Stacul F, Thomsen HS, Morcos SK (2003) Late reactions to intravascular iodinated contrast media. Eur Radiol 13:181–184CrossRefPubMed
Metadata
Title
Recent hot topics in contrast media
Author
Henrik S. Thomsen
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 3/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-2026-x

Other articles of this Issue 3/2011

European Radiology 3/2011 Go to the issue