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Open Access 01-07-2010 | Neuro

Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla

Authors: Birgit Simon, Stephan Schmidt, Carsten Lukas, Jürgen Gieseke, Frank Träber, Dirk L. Knol, Winfried A. Willinek, Jeroen J. G. Geurts, Hans H. Schild, Frederik Barkhof, Mike P. Wattjes

Published in: European Radiology | Issue 7/2010

Abstract

Objective

To investigate the impact of a higher magnetic field strength of 3 Tesla (T) on the detection rate of cortical lesions in multiple sclerosis (MS) patients, in particular using a dedicated double inversion recovery (DIR) pulse sequence.

Methods

Thirty-four patients with clinically isolated syndromes or definite MS were included. All patients underwent magnetic resonance imaging (MRI) at 1.5 T and 3 T, including T2-weighted turbo spin echo (TSE), fluid-attenuated inversion recovery (FLAIR) and DIR sequences. All images were analysed for focal lesions categorised according to their anatomical location.

Results

The total number of detected lesions was higher at 3 T across all pulse sequences. We observed significantly higher numbers of lesions involving the cortex at 3 T using a DIR sequence. DIR at 3 T showed 192% more pure intracortical (p < 0.001) and 30% more mixed grey matter-white matter lesions (p = 0.008). No significant increase in cortical lesions could be detected on the FLAIR and T2-weighted images. Using the T2-weighted and FLAIR sequences, significantly more lesions could be detected at 3 T in the infratentorial, periventricular and juxtacortical white matter.

Conclusion

DIR brain MR imaging at 3 T substantially improves the sensitivity of the detection of cortical lesions compared with the standard magnetic field strength of 1.5 T.

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Title: Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla
Authors: Birgit Simon
Stephan Schmidt
Carsten Lukas
Jürgen Gieseke
Frank Träber
Dirk L. Knol
Winfried A. Willinek
Jeroen J. G. Geurts
Hans H. Schild
Frederik Barkhof
Mike P. Wattjes
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 7/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1705-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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