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Open Access 01-09-2008 | Magnetic Resonance

Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology

Authors: Thomas C. Kwee, Taro Takahara, Reiji Ochiai, Rutger A. J. Nievelstein, Peter R. Luijten

Published in: European Radiology | Issue 9/2008

Abstract

Diffusion-weighted magnetic resonance imaging (DWI) provides functional information and can be used for the detection and characterization of pathologic processes, including malignant tumors. The recently introduced concept of “diffusion-weighted whole-body imaging with background body signal suppression” (DWIBS) now allows acquisition of volumetric diffusion-weighted images of the entire body. This new concept has unique features different from conventional DWI and may play an important role in whole-body oncological imaging. This review describes and illustrates the basics of DWI, the features of DWIBS, and its potential applications in oncology.

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World Health Organization (2005) International union against cancer. Global action against cancer. WHO Press, Geneva

Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1999) Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients. Abdom Imaging 24:456–461PubMedCrossRef

Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1998) Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions. AJR Am J Roentgenol 170:397–402PubMed

Muller MF, Prasad P, Siewert B et al (1994) Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 190:475–478PubMed

Muller MF, Prasad P, Bimmler D et al (1994) Functional imaging of the kidney by means of measurement of the apparent diffusion coefficient. Radiology 193:711–715PubMed

Edelman RR, Gaa J, Wedeen VJ et al (1994) In vivo measurement of water diffusion in the human heart. Magn Reson Med 32:423–428PubMedCrossRef

Bammer R (2003) Basic principles of diffusion-weighted imaging. Eur J Radiol 45:169–184PubMedCrossRef

Glockner JF, Hu HH, Stanley DW, Angelos L, King K (2005) Parallel MR imaging: a user’s guide. Radiographics 25:1279–1297PubMedCrossRef

Thoeny HC, De Keyzer F (2007) Extracranial applications of diffusion-weighted magnetic resonance imaging. Eur Radiol 17:1385–1393PubMedCrossRef

10.

Koh DM, Collins DJ (2007) Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR Am J Roentgenol 188:1622–1635PubMedCrossRef

11.

Low RN, Gurney J (2007) Diffusion-weighted MRI (DWI) in the oncology patient: value of breathhold DWI compared to unenhanced and gadolinium-enhanced MRI. J Magn Reson Imaging 25:848–858PubMedCrossRef

12.

Nasu K, Kuroki Y, Nawano S et al (2006) Hepatic metastases: diffusion-weighted sensitivity-encoding versus SPIO-enhanced MR imaging. Radiology 239:122–130PubMedCrossRef

13.

Yoshikawa T, Kawamitsu H, Mitchell DG et al (2006) ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol 187:1521–1530PubMedCrossRef

14.

Nasu K, Kuroki Y, Kuroki S, Murakami K, Nawano S, Moriyama N (2004) Diffusion-weighted single shot echo planar imaging of colorectal cancer using a sensitivity-encoding technique. Jpn J Clin Oncol 34:620–626PubMedCrossRef

15.

Taouli B, Martin AJ, Qayyum A et al (2004) Parallel imaging and diffusion tensor imaging for diffusion-weighted MRI of the liver: preliminary experience in healthy volunteers. AJR Am J Roentgenol 183:677–680PubMed

16.

Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M (2004) Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 22:275–282PubMed

17.

Ballon D, Watts R, Dyke JP et al (2004) Imaging therapeutic response in human bone marrow using rapid whole-body MRI. Magn Reson Med 52:1234–1238PubMedCrossRef

18.

Stejskal EO, Tanner JE (1965) Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 42:288–292CrossRef

19.

Turner R, Le Bihan D, Maier J et al (1990) Echo-planar imaging of intravoxel incoherent motion. Radiology 177:407–414PubMed

20.

Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMed

21.

Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurological disorders. Radiology 161:401–407PubMed

22.

Le Bihan D (1991) Molecular diffusion nuclear magnetic resonance imaging. Magn Reson Q 7:1–30PubMed

23.

Provenzale JM, Mukundan S, Barboriak DP (2006) Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response. Radiology 239:632–649PubMedCrossRef

24.

Delfaut EM, Beltran J, Johnson G, Rousseau J, Marchandise X, Cotten A (1999) Fat suppression in MR imaging: techniques and pitfalls. Radiographics 19:373–382PubMed

25.

Li S, Sun F, Jin ZY, Xue HD, Li ML (2007) Whole-body diffusion-weighted imaging: technical improvement and preliminary results. J Magn Reson Imaging 26:1139–1144PubMedCrossRef

26.

Torabi M, Aquino SL, Harisinghani MG (2004) Current concepts in lymph node imaging. J Nucl Med 45:1509–1518PubMed

27.

Will O, Purkayastha S, Chan C et al (2006) Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis. Lancet Oncol 7:52–60PubMedCrossRef

28.

Jaffe CC (2006) Measures of response: RECIST, WHO, and new alternatives. J Clin Oncol 24:3245–3251PubMedCrossRef

29.

Weber WA (2006) Positron emission tomography as an imaging biomarker. J Clin Oncol 24:3282–3292PubMedCrossRef

30.

Hamstra DA, Rehemtulla A, Ross BD (2007) Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology. J Clin Oncol 25:4104–4109PubMedCrossRef

31.

Hamstra DA, Chenevert TL, Moffat BA et al (2005) Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma. Proc Natl Acad Sci USA 102:16759–16764PubMedCrossRef

32.

Moffat BA, Chenevert TL, Lawrence TS et al (2005) Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci USA 102:5524–5529PubMedCrossRef

33.

Lee KC, Bradley DA, Hussain M et al (2007) A feasibility study evaluating the functional diffusion map as a predictive imaging biomarker for detection of treatment response in a patient with metastatic prostate cancer to the bone. Neoplasia 9:1003–1011PubMedCrossRef

34.

Rohren EM, Turkington TG, Coleman RE (2004) Clinical applications of PET in oncology. Radiology 231:305–332PubMedCrossRef

35.

Ichikawa T, Erturk SM, Motosugi U et al (2006) High-B-value diffusion-weighted MRI in colorectal cancer. AJR Am J Roentgenol 187:181–184PubMedCrossRef

36.

Ichikawa T, Erturk SM, Motosugi U et al (2007) High-b value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: preliminary results. AJR Am J Roentgenol 188:409–414PubMedCrossRef

37.

Tsushima Y, Takano A, Taketomi-Takahashi A, Endo K (2007) Body diffusion-weighted MR imaging using high b-value for malignant tumor screening: usefulness and necessity of referring to T2-weighted images and creating fusion images. Acad Radiol 14:643–650PubMedCrossRef

38.

Komori T, Narabayashi I, Matsumura K et al (2007) 2-[Fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography versus whole-body diffusion-weighted MRI for detection of malignant lesions: initial experience. Ann Nucl Med 21:209–215PubMedCrossRef

39.

Tamai K, Koyama T, Saga T et al (2007) Diffusion-weighted MR imaging of uterine endometrial cancer. J Magn Reson Imaging 26:682–687PubMedCrossRef

40.

Tamai K, Koyama T, Saga T et al (2007) The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas. Eur Radiol DOI 10.1007/s00330-007-0787-7

41.

Stadnik TW, Demaerel P, Luypaert RR et al (2003) Imaging tutorial: differential diagnosis of bright lesions on diffusion-weighted MR images. Radiographics 23:e7PubMedCrossRef

42.

Muro I, Takahara T, Horie T et al (2005) Influence of respiratory motion in body diffusion weighted imaging under free breathing (examination of a moving phantom). Nippon Hoshasen Gijutsu Gakkai Zasshi 61:1551–1558PubMed

43.

Nasu K, Kuroki Y, Sekiguchi R, Nawano S (2006) The effect of simultaneous use of respiratory triggering in diffusion-weighted imaging of the liver. Magn Reson Med Sci 5:129–136PubMedCrossRef

44.

Takahara T, Ogino T, Okuaki T et al (2007) Respiratory gated body diffusion weighted imaging avoiding prolongation of scan time: tracking only navigator echo (TRON) technique. Presented at the Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, May 19–25, 2007

45.

Laghi A, Paolantonio P, Iafrate F, Altomari F, Miglio C, Passariello R (2002) Oral contrast agents for magnetic resonance imaging of the bowel. Top Magn Reson Imaging 13:389–396PubMedCrossRef

46.

Kuhl CK, Textor J, Gieseke J et al (2005) Acute and subacute ischemic stroke at high-field-strength (3.0-T) diffusion-weighted MR imaging: intraindividual comparative study. Radiology 234:509–516PubMedCrossRef

47.

Murtz P, Krautmacher C, Traber F, Gieseke J, Schield HH, Willinek WA (2007) Diffusion-weighted whole-body MR imaging with background body signal suppression: a feasibility study at 3.0 Tesla. Eur Radiol 17:3031–3037PubMedCrossRef

Title: Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology
Authors: Thomas C. Kwee
Taro Takahara
Reiji Ochiai
Rutger A. J. Nievelstein
Peter R. Luijten
Publication date: 01-09-2008
Publisher: Springer-Verlag
Published in: European Radiology / Issue 9/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-0968-z

At a glance: The STEP trials

Springer Medicine

Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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