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European Radiology
Published in: European Radiology 5/2008

01-05-2008 | Urogenital

Diffusion-weighted MRI in cervical cancer

Authors: Patrick Z. McVeigh, Aejaz M. Syed, Michael Milosevic, Anthony Fyles, Masoom A. Haider

Published in: European Radiology | Issue 5/2008

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Abstract

The purpose was to investigate the potential value of apparent diffusion coefficient (ADC) measurement with MRI in the assessment of cervix cancer. Diffusion-weighted MRI was performed in 47 patients with cervical carcinoma undergoing chemoradiation therapy and 26 normal controls on a 1.5-T system with a b-value of 600 s/mm2. FIGO stage, tumor volume, nodal status, interstitial fluid pressure (IFP) and oxygen measurements were recorded. Response was defined as no visible tumor 3–6 months following completion of therapy. The average median ADC (mADC) of cervical carcinomas (1.09±0.20×10−3 mm2/s) was significantly lower than normal cervix (2.09±0.46×10−3 mm2/s) (P<0.001). There was no correlation between mADC, nodal status, tumor volume, IFP or oxygen measurements. mADC was significantly lower in FIGO stages T1b/T2a (0.986 × 10−3 mm2/s) compared to T2b (1.21×10−3 mm2/s) and T3/T4 (1.10×10−3 mm2/s) (P<0.001). In patients with squamous carcinomas the 90th percentile of ADC values was lower in responders than non-responders (P<0.05). Median ADC in cervix carcinoma is significantly lower compared to normal cervix. ADC may have predictive value in squamous tumors, but further long-term study will determine the ultimate clinical utility.
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Metadata
Title
Diffusion-weighted MRI in cervical cancer
Authors
Patrick Z. McVeigh
Aejaz M. Syed
Michael Milosevic
Anthony Fyles
Masoom A. Haider
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
European Radiology / Issue 5/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-007-0843-3

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