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European Radiology
Published in: European Radiology 10/2007

01-10-2007 | Neuro

Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis

Authors: Yoshimitsu Ohgiya, Masaki Oka, Akio Hiwatashi, Xiang Liu, Naoya Kakimoto, Per-Lennart A. Westesson, Sven E. Ekholm

Published in: European Radiology | Issue 10/2007

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Abstract

Our purpose was to evaluate the ability of diffusion tensor imaging (DTI) to characterize cervical spinal cord white matter (WM) in patients with multiple sclerosis (MS). DTI were obtained in 21 MS patients and 21 control subjects (CS). Regions of interest (ROIs) were placed at C2/3, C3/4, and C4/5 within the right, left, and dorsal (WM) to calculate fractional anisotropy (FA) and the apparent diffusion coefficient (ADC). Measurements in plaques and normal-appearing white matter (NAWM) of MS patients were compared with mean FA and ADC of WM in CS. FA was significantly lower in all regions in MS patients than in CS. ADC was significantly higher in all regions in MS patients than in CS except for in the dorsal WM at C2/3 and the bilateral WM at C4/5. The mean FA was 0.441 for plaques and 0.542 for NAWM, as compared with 0.739 in CS. The mean ADC was 0.810 × 10−3 mm2/s for plaques and 0.722 × 10−3 mm2/s for NAWM, as compared with 0.640 ×10−3 mm2/s for CS. FA and ADC showed significant differences between plaques, NAWM and control WM(P < 0.01).
Literature
1.
Uldry PA, Regli F, Uske A (1993) Magnetic resonance imaging in patients with multiple sclerosis and spinal cord involvement: 28 cases. J Neurol 240:41–45PubMedCrossRef
2.
Hittmair K, Mallek R, Prayer D, Schindler EG, Kollegger H (1996) Spinal cord lesions in patients with multiple sclerosis: comparison of MR pulse sequences. AJNR Am J Neuroradiol 17:1555–1565PubMed
3.
Lycklama a Nijeholt GJ, Barkhof F, Scheltens P, Castelijns JA, Ader H, van Waesberghe JH, Polman C, Jongen SJ, Valk J (1997) MR of the spinal cord in multiple sclerosis: relation to clinical subtype and disability. AJNR Am J Neuroradiol 18:1041–1048PubMed
4.
Werring DJ, Clark CA, Barker GJ, Thompson AJ, Miller DH (1999) Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 52:1626–1632PubMed
5.
Tievsky AL, Ptak T, Farkas J (1999) Investigation of apparent diffusion coefficient and diffusion tensor anisotropy in acute and chronic multiple sclerosis lesions. AJNR Am J Neuroradiol 20:1491–1499PubMed
6.
Bammer R, Augustin M, Strasser-Fuchs S, Seifert T, Kapeller P, Stollberger R, Ebner F, Hartung HP, Fazekas F (2000) Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magn Reson Med 44:583–591PubMedCrossRef
7.
Guo AC, MacFall JR, Provenzale JM (2002) Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. Radiology 222:729–736PubMedCrossRef
8.
Filippi M, Rocca MA, Comi G (2003) The use of quantitative magnetic-resonance-based techniques to monitor the evolution of multiple sclerosis. Lancet Neurol 2:337–346PubMedCrossRef
9.
Kealey SM, Kim Y, Provenzale JM (2004) Redefinition of multiple sclerosis plaque size using diffusion tensor MRI. AJR Am J Roentgenol 183:497–503PubMed
10.
Kealey SM, Kim Y, Whiting WL, Madden DJ, Provenzale JM (2005) Determination of multiple sclerosis plaque size with diffusion-tensor MR Imaging: comparison study with healthy volunteers. Radiology 236:615–620PubMedCrossRef
11.
Sijens PE, Irwan R, Potze JH, Mostert JP, De Keyser J, Oudkerk M (2005) Analysis of the human brain in primary progressive multiple sclerosis with mapping of the spatial distributions using 1H MR spectroscopy and diffusion tensor imaging. Eur Radiol 15:1686–1693PubMedCrossRef
12.
Pattany PM, Puckett WR, Klose KJ, Quencer RM, Bunge RP, Kasuboski L, Weaver RG (1997) High-resolution diffusion-weighted MR of fresh and fixed cat spinal cords: evaluation of diffusion coefficients and anisotropy. AJNR Am J Neuroradiol 18:1049–1056PubMed
13.
Bergers E, Bot JC, De Groot CJ, Polman CH, Lycklama a Nijeholt GJ, Castelijns JA, van der Valk P, Barkhof F (2002) Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions. Neurology 59:1766–1771PubMed
14.
Bot JC, Blezer EL, Kamphorst W, Lycklama A Nijeholt GJ, Ader HJ, Castelijns JA, Ig KN, Bergers E, Ravid R, Polman C, Barkhof F (2004) The spinal cord in multiple sclerosis: relationship of high-spatial-resolution quantitative MR imaging findings to histopathologic results. Radiology 233:531–540PubMedCrossRef
15.
Clark CA, Werring DJ, Miller DH (2000) Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis. Magn Reson Med 43:133–138PubMedCrossRef
16.
Agosta F, Benedetti B, Rocca MA, Valsasina P, Rovaris M, Comi G, Filippi M (2005) Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI. Neurology 64:631–635PubMed
17.
Valsasina P, Rocca MA, Agosta F, Benedetti B, Horsfield MA, Gallo A, Rovaris M, Comi G, Filippi M (2005) Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients. Neuroimage 26:822–828PubMedCrossRef
18.
Hesseltine SM, Law M, Babb J, Rad M, Lopez S, Ge Y, Johnson G, Grossman RI (2006) Diffusion tensor imaging in multiple sclerosis: assessment of regional differences in the axial plane within normal-appearing cervical spinal cord. AJNR Am J Neuroradiol 27:1189–1193PubMed
19.
Mottershead JP, Schmierer K, Clemence M, Thornton JS, Scaravilli F, Barker GJ, Tofts PS, Newcombe J, Cuzner ML, Ordidge RJ, McDonald WI, Miller DH (2003) High field MRI correlates of myelin content and axonal density in multiple sclerosis-a post-mortem study of the spinal cord. J Neurol 250:1293–1301PubMedCrossRef
20.
Sijens PE, Irwan R, Potze JH, Mostert JP, De Keyser J, Oudkerk M (2006) Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis. Eur Radiol 16:898–904PubMedCrossRef
21.
Holder CA, Muthupillai R, Mukundan S Jr, Eastwood JD, Hudgins PA (2000) Diffusion-weighted MR imaging of the normal human spinal cord in vivo. AJNR Am J Neuroradiol 21:1799–1806PubMed
Metadata
Title
Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis
Authors
Yoshimitsu Ohgiya
Masaki Oka
Akio Hiwatashi
Xiang Liu
Naoya Kakimoto
Per-Lennart A. Westesson
Sven E. Ekholm
Publication date
01-10-2007
Publisher
Springer-Verlag
Published in
European Radiology / Issue 10/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-007-0672-4

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