Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 10/2007

01-10-2007 | Musculoskeletal

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

Authors: F. Alyas, S. L. James, A. M. Davies, A. Saifuddin

Published in: European Radiology | Issue 10/2007

Login to get access

Abstract

MRI has an established role in the local staging of primary bone tumours. However, as the majority of tumours have non-specific appearances on MRI, the diagnosis is usually established on the basis of clinical history, plain film findings and biopsy. This article reviews the value of MRI in the further characterisation of appendicular bone tumours and tumour-like lesions, with particular reference to peri-lesional oedema, fluid-fluid levels, flow voids, fat signal, cartilage signal and dedifferentiation. These features are a useful adjunct for distinguishing between benign and malignant disease, pointing towards a more specific diagnosis, and guiding biopsy.
Literature
1.
Priolo F, Cerase A (1998) The current role of radiography in the assessment of skeletal tumors and tumor-like lesions. Eur J Radiol 27:S77–S85PubMedCrossRef
2.
Rechl H, Hof N, Gerdesmeier L (2001) Differential diagnosis of bone and soft tissue tumors by MRI. Orthopade 30:528–539PubMedCrossRef
3.
Leung JC, Dalinka MK (2000) Magnetic resonance imaging in primary bone tumors. Semin Roentgenol 35:297–305PubMedCrossRef
4.
Kroon HM, Bloem JL, Holscher HC, van der Woude HJ, Reijnierse M, Taminiau AH (1994) MR imaging of edema accompanying benign and malignant bone tumors. Skeletal Radiol 23:261–269PubMedCrossRef
5.
Holscher HC, Bloem JL, Vanel D et al (1992) Osteosarcoma: chemotherapy-induced changes at MR imaging. Radiology 182:839–844PubMed
6.
Lang P, Honda G, Roberts T et al (1995) Musculoskeletal neoplasm-perineoplastic edema versus tumour on dynamic postcontrast MR-images with spatial-mapping of instantaneous enhancement rates. Radiology 197:831–839PubMed
7.
Erdman WA, Tamburro F, Jayson HT, Weatherall PT, Ferry KB, Peshock RM (1991) Osteomyelitis: characteristics and pitfalls of diagnosis with MR imaging. Radiology 180:533–539PubMed
8.
Hanna SL, Fletcher FL, Parham PD, Bugg MF (1991) Muscle oedema in musculoskeletal tumours: MR imaging characteristics and clinical significance. J Magn Reson Imaging 1:441–449PubMedCrossRef
9.
Oxtoby JW, Davies AM (1996) MRI characteristics of chondroblastoma. Clin Radiol 5:22–26CrossRef
10.
Assoun J, Richardi G, Railhac JJ (1994) Osteoid osteoma: MR imaging versus CT. Radiology 191:217–223PubMed
11.
James SLJ, Hughes R, Ali K (2006) Saifuddin A MR imaging of bone marrow oedema associated with focal bone lesions. Clin Radiol 61:1003–1009PubMedCrossRef
12.
Ehara S, Rosenthal DI, Aoki J et al (1999) Peritumoral edema in osteoid osteoma on magnetic resonance imaging. Skeletal Radiol 28:265–270PubMedCrossRef
13.
14.
Ebrahim FS, Jacobson JA, Lin J, Housner JA, Hayes CW, Resnick D (2001) Intraarticular osteoid osteoma: sonographic findings in three patients with radiographic, CT, and MR imaging correlation. AJR Am J Roentgenol 177:1391–1395PubMed
15.
Hudson TM, Hamlin DJ, Fitzsimmons JR (1985) Magnetic resonance imaging of fluid levels in an aneurysmal bone cyst and in anticoagulated human blood. Skeletal Radiol 3:267–270CrossRef
16.
Mahnken AH, Nolte-Ernsting CC, Wildberger JE et al (2003) Aneurysmal bone cyst: value of MR imaging and conventional radiography. Eur Radiol 13:1118–1124PubMedCrossRef
17.
Tsai JC, Dalinka MK, Fallon MD, Zlatkin MB, Kressel HY (1990) Fluid-fluid level: a non-specific finding in tumors of bone and soft tissue. Radiology 175:779–782PubMed
18.
Van Dyck P, Vanhoenacker FM, Vogel J et al (2006) Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol 16:2644–2651PubMedCrossRef
19.
Bonakdarpour A, Levy WM, Aegerter E (1978) Primary and secondary aneurysmal bone cyst: a radiological study of 75 cases. Radiology 126:75–83PubMed
20.
Kransdorf MJ, Sweet DE (1995) Aneurysmal bone cyst: concept, controversies, patient presentation, and imaging. AJR Am J Roentgenol 164:573–580PubMed
21.
Szendroi M, Cser I, Konya A, Renyi-Vamos A (1992) Aneurysmal bone cyst. A review of 52 primary and 16 secondary cases. Arch Orthop Trauma Surg 111:318–322PubMedCrossRef
22.
Jaffe HL (1950) Aneurysmal bone cyst. Bull Hosp Joint Dis 11:3–13PubMed
23.
Mirra JM (1989) Chondroblastoma. In: Mirra JM, Picci P, Gold RH (eds) Bone tumors. Lea & Febiger, Philadelphia, pp 589–623
24.
Kroon HM, Schurmans J (1990) Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology 175:783–790PubMed
25.
O’Donnell P, Saifuddin A (2004) The prevalence and diagnostic significance of fluid-fluid levels in focal lesions of bone. Skeletal Radiol 33:330–336PubMedCrossRef
26.
Bradley WG Jr (1988) Carmen lecture. Flow phenomena in MR imaging. AJR Am J Roentgenol 150:983–994PubMed
27.
Choi JA, Lee KH, Jun WS, Yi MG, Lee S, Kang HS (2003) Osseous metastasis from renal cell carcinoma: “flow-void” sign at MR imaging. Radiology 228:629–634PubMedCrossRef
28.
Murakami R, Korogi Y, Sakamoto Y et al (1995) Skull metastasis from hepatocellular carcinoma. CT, MR and angiographic findings. Acta Radiol 36:597–602PubMedCrossRef
29.
30.
Lorigan JG, O’Keeffe FN, Evans HL, Wallace S (1989) The radiologic manifestations of alveolar soft-part sarcoma. AJR Am J Roentgenol 153:335–339PubMed
31.
Murphey MD, Fairbairn KJ, Parman LM, Baxter KG, Parsa MB, Smith WS (1995) Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics 15:893–917PubMed
32.
Mahnken AH, Tacke J, Wolter P, Buttner R, Haller JS, Gunther RW (2002) Cross-sectional imaging of primary osseous hemangiopericytoma. Eur Radiol 12:85–89PubMedCrossRef
33.
Torigoe T, Matsumoto T, Terakado A, Takase M, Yamasaki S, Kurosawa H (2005) Primary pleomorphic liposarcoma of bone: MRI findings and review of the literature. Skeletal Radiol 21:1–3
34.
Murphey MD, Arcara LK, Fanburg-Smith J (2005) From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics 25:1371–1395PubMedCrossRef
35.
Marx HF, Colletti PM, Raval JK, Boswell WD Jr, Zee CS (1990) Magnetic resonance imaging features in melanoma. Magn Reson Imaging 8:223–229PubMedCrossRef
36.
Campbell RS, Grainger AJ, Mangham DC, Beggs I, Teh J, Davies AM (2003) Intraosseous lipomas: report of 35 cases and a review of the literature. Skeletal Radiol 32:209–222PubMedCrossRef
37.
Propeck T, Bullard MA, Lin J, Doi K, Martel W (2000) Radiologic-pathologic correlation of intraosseous lipomas. AJR Am J Roentgenol 175:673–678PubMed
38.
Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ (2004) From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 24:1433–1466PubMedCrossRef
39.
Wenger DE, Wold LE (2000) Benign vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol 29:63–74PubMedCrossRef
40.
Beltran J, Herman LJ, Burk JM et al (1988) Femoral head avascular necrosis: MR imaging with clinical-pathologic and radionuclide correlation. Radiology 166:215–220PubMed
41.
Sundaram M, Khanna G, El-Khoury GY (2001) T1-weighted MR imaging for distinguishing large osteolysis of Paget’s disease from sarcomatous degeneration. Skeletal Radiol 30:378–383PubMedCrossRef
42.
Schweitzer ME, Levine C, Mitchell DG, Gannon FH, Gomella LG (1993) Bull’s-eyes and halos: useful MR discriminators of osseous metastases. Radiology 188:249–252PubMed
43.
Wada R, Lambert RG (2005) Deposition of intraosseous fat in a degenerating simple bone cyst. Skeletal Radiol 34:415–418PubMedCrossRef
44.
45.
46.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH (2003) From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics 23:1245–1278PubMedCrossRef
47.
Cohen EK, Kressel HY, Frank TS et al (1988) Hyaline cartilage-origin bone and soft-tissue neoplasms: MR appearance and histologic correlation. Radiology 167:477–481PubMed
48.
Murphey MD, Flemming DJ, Boyea SR, Bojescul JA, Sweet DE, Temple HT (1998) Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics 18:1213–1237PubMed
49.
Giudici MA, Moser RP, Kransdorf MJ (1993) Cartilaginous tumours of bone. Radiol Clin North Am 31:237–259PubMed
50.
Aoki J, Sone S, Fujioka F et al (1991) MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr 15:1011–1016PubMedCrossRef
51.
De Beuckeleer LH, De Schepper AM, Ramon F, Somville J (1995) Magnetic resonance imaging of cartilaginous tumors: a retrospective study of 79 patients. Eur J Radiol 21:34–40PubMedCrossRef
52.
Mirra JM, Gold R, Downs J, Eckardt JJ (1985) A new histologic approach to the differentiation of enchondroma and chondrosarcoma. Clin Orthop 201:214–237PubMed
53.
Geirnaerdt MJ, Hogendoorn PC, Bloem JL, Taminiau AH, van der Woude HJ (2000) Cartilaginous tumors: fast contrast-enhanced MR imaging. Radiology 214:539–546PubMed
54.
Malgheni J, Berg BV, Noel H, Maldague B (1992) Benign osteochondromas and exostotic chondrosarcomas: evaluation of cartilage cap thickness by ultrasound. Skeletal Radiol 21:33–37
55.
Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH (2000) Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics 20:1407–1434PubMed
56.
Woertler K, Lindner N, Gosheger G, Brinkschmidt C, Heindel W (2000) Osteochondroma: MR imaging of tumor-related complications. Eur Radiol 10:832–840PubMedCrossRef
57.
Karasick D, Schweitzer ME, Eschelman DJ (1997) Symptomatic osteochondromas: imaging features. AJR Am J Roentgenol 168:1507–1512PubMed
58.
Norman A, Sissons HA (1984) Radiographic hallmarks of peripheral chondrosarcoma. Radiology 151:589–596PubMed
59.
Jee WH, Choe BY, Kang HS et al (1998) Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology 209:197–202PubMed
60.
Frick MA, Sundaram M, Unni KK et al (2005) Imaging findings in desmoplastic fibroma of bone: distinctive T2 Characteristics. AJR Am J Roentgenol 184:1762–1767PubMed
61.
Vanhoenacker FM, Hauben E, De Beuckeleer LH, Willemen D, Van Marck E, De Schepper AM (2000) Desmoplastic fibroma of bone: MRI features. Skeletal Radiol 29:171–175PubMedCrossRef
62.
Aoki J, Tanikawa H, Ishii K et al (1996) MR findings indicative of hemosiderin in giant-cell tumour of bone: frequency, cause, and diagnostic significance. AJR Am J Roentgenol 166:145–148PubMed
63.
Picci P, Baldini N, Sudanese A, Boniani S, Campanacci M (1986) Giant cell reparative granuloma and other giant cell lesions of the bones of the hands and feet. Skeletal Radiol 15:415–421PubMedCrossRef
64.
Ilaslan H, Sundaram M, Unni KK (2003) Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. AJR Am J Roentgenol 180:1681–1687PubMed
65.
66.
Mercuri M, Picci P, Campanacci L, Rulli E (1995) Dedifferentiated chondrosarcoma. Skeletal Radiol 24:409–416PubMedCrossRef
67.
MacSweeney F, Darby A, Saifuddin A (2003) Dedifferentiated chondrosarcoma of the appendicular skeleton: MRI-pathological correlation. Skeletal Radiol 32:671–678PubMedCrossRef
68.
Saifuddin A, Mann BS, Mahroof S, Pringle JA, Briggs TW, Cannon SR (2004) Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy. Clin Radiol 59:268–272PubMedCrossRef
69.
Futani H, Okayama A, Maruo S, Kinoshita G, Ishikura R (2001) The role of imaging modalities in the diagnosis of primary dedifferentiated parosteal osteosarcoma. J Orthop Sci 6:290–294PubMedCrossRef
70.
Shuhaibar H, Friedman L (1998) Dedifferentiated parosteal osteosarcoma with high-grade osteoclast-rich osteogenic sarcoma at presentation. Skeletal Radiol 27:574–577PubMedCrossRef
71.
Jelinek JS, Murphey MD, Kransdorf MJ, Shmookler BM, Malawer MM, Hur RC (1996) Parosteal osteosarcoma: value of MR imaging and CT in the prediction of histologic grade. Radiology 201:837–842PubMed
Metadata
Title
The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions
Authors
F. Alyas
S. L. James
A. M. Davies
A. Saifuddin
Publication date
01-10-2007
Publisher
Springer-Verlag
Published in
European Radiology / Issue 10/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-007-0597-y

Other articles of this Issue 10/2007

European Radiology 10/2007 Go to the issue

Neuro

Diffusion tensor MR imaging of the cervical spinal cord in patients with multiple sclerosis

Head and Neck

Extension patterns of nasopharyngeal carcinoma

Head and Neck

Diagnostic ability of apparent diffusion coefficients for lymphomas and carcinomas in the pharynx

Musculoskeletal

Vertebroplasty in the treatment of osteoporotic vertebral body fracture

Breast

Quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesion

Urogenital

MDCT urography: experience with a bi-phasic excretory phase examination protocol