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01-05-2007 | Chest

Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT

Authors: Marco Das, Georg Mühlenbruch, Andreas H. Mahnken, K. G. Hering, H. Sirbu, W. Zschiesche, Lars Knoll, Michael K. Felten, Thomas Kraus, Rolf W. Günther, Joachim E. Wildberger

Published in: European Radiology | Issue 5/2007

Abstract

The purpose of this study was to assess the prevalence of lung cancer in a high-risk asbestos-exposed cohort using low-dose MDCT. Of a population of 5,389 former power-plant workers, 316 were characterized as individuals at highest risk for lung cancer according to a lung-cancer risk model including age, asbestos exposure and smoking habits. Of these 316, 187 (mean age: 66.6 years) individuals were included in a prospective trial. Mean asbestos exposure time was 29.65 years and 89% were smokers. Screening was performed on a 16-slice MDCT (Siemens) with low-dose technique (10/20 mAs_eff.; 1 mm/0.5 mm increment). In addition to soft copy PACS reading analysis on a workstation with a dedicated lung analysis software (LungCARE; Siemens) was performed. One strongly suspicious mass and eight cases of histologically proven lung cancer were found plus 491 additional pulmonary nodules (average volume: 40.72 ml, average diameter 4.62 mm). Asbestos-related changes (pleural plaques, fibrosis) were visible in 80 individuals. Lung cancer screening in this high-risk cohort showed a prevalence of lung cancer of 4.28% (8/187) at baseline screening with an additional large number of indeterminate pulmonary nodules. Low-dose MDCT proved to be feasible in this highly selected population.

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Title: Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT
Authors: Marco Das
Georg Mühlenbruch
Andreas H. Mahnken
K. G. Hering
H. Sirbu
W. Zschiesche
Lars Knoll
Michael K. Felten
Thomas Kraus
Rolf W. Günther
Joachim E. Wildberger
Publication date: 01-05-2007
Publisher: Springer-Verlag
Published in: European Radiology / Issue 5/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0426-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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