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01-01-2016 | Original Article - Genes and Disease

The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review

Authors: Si Chen, Yuan Li, Chuiwen Deng, Jing Li, Xiaoting Wen, Ziyan Wu, Chaojun Hu, Shulan Zhang, Ping Li, Xuan Zhang, Fengchun Zhang, Yongzhe Li

Published in: Rheumatology International | Issue 1/2016

Abstract

Previous surveys had evaluated the effects of the PD-1, CTLA-4 gene polymorphisms on susceptibility to ankylosing spondylitis (AS), but the results remained controversial. To briefly examine these consequences, a comprehensive meta-analysis was conducted to estimate the relationships between PD-1 rs11568821, rs2227982, rs2227981, CTLA-4 +49 A/G and −318 C/T polymorphisms and AS risk. The available articles dated to December 2014 were searched in the PUBMED, MEDLINE and EMBASE databases. The data of the genotypes and/or alleles for the PD-1 rs11568821, rs2227982, rs2227981, CTLA-4 +49 A/G and −318 C/T polymorphisms in the AS and control subjects were extracted, and statistical analysis was conducted by STATA 11.2 software. Summary odds ratios (ORs) with their 95 % confidence intervals (95 % CIs) were calculated to determine the strength of associations with fixed-effects or random-effects models. A total of eight published studies were finally involved in this meta-analysis. Meta-analysis of PD-1 rs2227982 polymorphism under the T allele versus C allele (OR 1.744, 95 % CI 1.477–2.059, P < 0.0001), TT+TC versus CC (OR 2.292, 95 % CI 1.654–3.175, P < 0.0001), TT versus CC (OR 1.883, 95 % CI 1.299–2.729, P = 0.001) revealed a significant association with AS. Our meta-analysis demonstrated that the rs2227982 polymorphism in the PD-1 gene might contribute to AS susceptibility. However, further studies with large sample sizes and among different ethnicity populations should be required to confirm this association.

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Title: The associations between PD-1, CTLA-4 gene polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis and systemic review
Authors: Si Chen
Yuan Li
Chuiwen Deng
Jing Li
Xiaoting Wen
Ziyan Wu
Chaojun Hu
Shulan Zhang
Ping Li
Xuan Zhang
Fengchun Zhang
Yongzhe Li
Publication date: 01-01-2016
Publisher: Springer Berlin Heidelberg
Published in: Rheumatology International / Issue 1/2016
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-015-3327-9

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