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Published in: Rheumatology International 7/2015

01-07-2015 | Original Article - Clinical Trials

The addition of upper cervical manipulative therapy in the treatment of patients with fibromyalgia: a randomized controlled trial

Authors: Ibrahim M. Moustafa, Aliaa A. Diab

Published in: Rheumatology International | Issue 7/2015

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Abstract

The aim of this study was to investigate the immediate and long-term effects of a one-year multimodal program, with the addition of upper cervical manipulative therapy, on fibromyalgia management outcomes in addition to three-dimensional (3D) postural measures. This randomized clinical trial with one-year follow-up was completed at the research laboratory of our university. A total of 120 (52 female) patients with fibromyalgia syndrome (FMS) and definite C1-2 joint dysfunction were randomly assigned to the control or an experimental group. Both groups received a multimodal program; additionally, the experimental group received upper cervical manipulative therapy. Primary outcomes were the Fibromyalgia Impact Questionnaire (FIQ), whereas secondary outcomes included Pain Catastrophizing Scale (PCS), algometric score, Pittsburgh Sleep Quality Index (PSQI), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and 3D postural measures. Measures were assessed at three time intervals: baseline, 12 weeks, and 1 year after the 12-week follow-up. The general linear model with repeated measures indicated a significant group × time effect in favor of the experimental group on the measures of 3D postural parameters (P < .0005), FIQ (P < .0005), PCS (P < .0005), algometric score (F = P < .0005), PSQI (P < .0005), BAI (P < .0005), and BDI (P < .0005). The addition of the upper cervical manipulative therapy to a multimodal program is beneficial in treating patients with FMS.
Literature
1.
go back to reference Smith HS, Harris R, Clauw D (2011) Fibromyalgia: an afferent processing disorder leading to a complex pain generalized syndrome. Pain Phys 14:E217–E245 Smith HS, Harris R, Clauw D (2011) Fibromyalgia: an afferent processing disorder leading to a complex pain generalized syndrome. Pain Phys 14:E217–E245
2.
go back to reference Mork PJ, Vasseljen O, Nilsen TI (2010) Association between physical exercise, body mass index, and risk of fibromyalgia: longitudinal data from the Norwegian Nord-Trondelag Health Study. Arthritis Care Res (Hoboken) 62:611–617CrossRef Mork PJ, Vasseljen O, Nilsen TI (2010) Association between physical exercise, body mass index, and risk of fibromyalgia: longitudinal data from the Norwegian Nord-Trondelag Health Study. Arthritis Care Res (Hoboken) 62:611–617CrossRef
4.
5.
go back to reference Mease PJ, Arnold LM, Crofford LJ et al (2008) Identifying the clinical domains of fibromyalgia: contributions from clinician and patient delphi exercises. Arthritis Rheum 59:603–952CrossRef Mease PJ, Arnold LM, Crofford LJ et al (2008) Identifying the clinical domains of fibromyalgia: contributions from clinician and patient delphi exercises. Arthritis Rheum 59:603–952CrossRef
6.
go back to reference Branco JC, Bannwarth B, Failde I et al (2010) Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum 39:448–453CrossRefPubMed Branco JC, Bannwarth B, Failde I et al (2010) Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum 39:448–453CrossRefPubMed
7.
go back to reference Nüesch E, Häuser W, Bernardy K et al (2013) Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis. Ann Rheum Dis 72(6):955–962CrossRefPubMed Nüesch E, Häuser W, Bernardy K et al (2013) Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis. Ann Rheum Dis 72(6):955–962CrossRefPubMed
8.
go back to reference Busse JW, Ebrahim S, Connell G et al (2013) Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol. Syst Rev 2(1):18CrossRefPubMedCentralPubMed Busse JW, Ebrahim S, Connell G et al (2013) Systematic review and network meta-analysis of interventions for fibromyalgia: a protocol. Syst Rev 2(1):18CrossRefPubMedCentralPubMed
9.
go back to reference Nöller V, Sprott H (2003) Prospective epidemiological observations on the course of the disease in fibromyalgia patients. J Negat Results Biomed 2:4–9CrossRefPubMedCentralPubMed Nöller V, Sprott H (2003) Prospective epidemiological observations on the course of the disease in fibromyalgia patients. J Negat Results Biomed 2:4–9CrossRefPubMedCentralPubMed
10.
go back to reference Hartz AJ, Noyes R, Bentler SE et al (2000) Unexplained symptoms in primary care: perspectives of doctors and patients. Gen Hosp Psychiatry 22:144–152CrossRefPubMed Hartz AJ, Noyes R, Bentler SE et al (2000) Unexplained symptoms in primary care: perspectives of doctors and patients. Gen Hosp Psychiatry 22:144–152CrossRefPubMed
11.
go back to reference Hiemeyer K, Lutz R, Menninger H (1990) Dependence of tender points upon posture: a key to the understanding of fibromyalgia syndrome. J Man Med 5:169–174 Hiemeyer K, Lutz R, Menninger H (1990) Dependence of tender points upon posture: a key to the understanding of fibromyalgia syndrome. J Man Med 5:169–174
12.
go back to reference Mueller A, Hartmann M, Eich W (2000) Inanspruchnahme medizinischer Versorgungsleistungen. Untersuchung bei Patienten mit Fibromyalgiesyndrom (FMS) [Health care utilization in patients with fibromyalgia syndrome (FMS)]. Schmerz 14:77–83 (German)CrossRef Mueller A, Hartmann M, Eich W (2000) Inanspruchnahme medizinischer Versorgungsleistungen. Untersuchung bei Patienten mit Fibromyalgiesyndrom (FMS) [Health care utilization in patients with fibromyalgia syndrome (FMS)]. Schmerz 14:77–83 (German)CrossRef
13.
go back to reference Bandakl E, Amris K, Bliddal H et al (2013) Muscle fatigue in fibromyalgia is in the brain, not in the muscles: a case–control study of perceived versus objective muscle fatigue. Ann Rheum Dis 72:963–966CrossRef Bandakl E, Amris K, Bliddal H et al (2013) Muscle fatigue in fibromyalgia is in the brain, not in the muscles: a case–control study of perceived versus objective muscle fatigue. Ann Rheum Dis 72:963–966CrossRef
14.
go back to reference Lee YC, Nassikas NJ, Clauw DJ (2011) The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther 13:211CrossRefPubMedCentralPubMed Lee YC, Nassikas NJ, Clauw DJ (2011) The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther 13:211CrossRefPubMedCentralPubMed
16.
go back to reference McLain RF, Pickar JG (1998) Mechanoreceptor endings in human thoracic and lumbar facet joints. Spine 23(2):168–173CrossRefPubMed McLain RF, Pickar JG (1998) Mechanoreceptor endings in human thoracic and lumbar facet joints. Spine 23(2):168–173CrossRefPubMed
17.
go back to reference Bankoul S, Neuhuber WL (1990) A cervical primary afferent input to vestibular nuclei as demonstrated by retrograde transport of wheat germ agglutinin-horseradish peroxidase in the rat. Exp Brain Res 79:405–411CrossRefPubMed Bankoul S, Neuhuber WL (1990) A cervical primary afferent input to vestibular nuclei as demonstrated by retrograde transport of wheat germ agglutinin-horseradish peroxidase in the rat. Exp Brain Res 79:405–411CrossRefPubMed
18.
go back to reference Neuhuber WL (1998) Characteristics of the innervation of the head and neck. Orthopade 27(12):794–801PubMed Neuhuber WL (1998) Characteristics of the innervation of the head and neck. Orthopade 27(12):794–801PubMed
19.
go back to reference Haavik-Taylor H, Murphy B (2007) Cervical spine manipulation alters sensorimotor integration: a somatosensory evoked potential study. Clin Neurophysiol 118(2):391–402CrossRefPubMed Haavik-Taylor H, Murphy B (2007) Cervical spine manipulation alters sensorimotor integration: a somatosensory evoked potential study. Clin Neurophysiol 118(2):391–402CrossRefPubMed
20.
go back to reference Haavik-Taylor H, Murphy B (2008) Altered sensorimotor integration with cervical spine manipulation. J Manipulative Physiol Ther 31(2):115–126CrossRef Haavik-Taylor H, Murphy B (2008) Altered sensorimotor integration with cervical spine manipulation. J Manipulative Physiol Ther 31(2):115–126CrossRef
21.
go back to reference Haavik-Taylor H, Murphy B (2012) The role of spinal manipulation in addressing disordered sensorimotor integration and altered motor control. J Electromyogr Kinesiol 22(5):768–776CrossRef Haavik-Taylor H, Murphy B (2012) The role of spinal manipulation in addressing disordered sensorimotor integration and altered motor control. J Electromyogr Kinesiol 22(5):768–776CrossRef
22.
go back to reference Murphy BA, Haavik-Taylor H, Wilson SA et al (2003) Changes in median nerve somatosensory transmission and motor output following transient deafferentation of the radial nerve in humans. Clin Neurophysiol 114(8):1477–1488CrossRefPubMed Murphy BA, Haavik-Taylor H, Wilson SA et al (2003) Changes in median nerve somatosensory transmission and motor output following transient deafferentation of the radial nerve in humans. Clin Neurophysiol 114(8):1477–1488CrossRefPubMed
23.
go back to reference Murphy BA, Haavik-Taylor H, Wilson SA et al (2003) Rapid reversible changes to multiple levels of the human somatosensory system following the cessation of repetitive contractions: a somatosensory evoked potential study. Clin Neurophysiol 114(8):1531–1537CrossRefPubMed Murphy BA, Haavik-Taylor H, Wilson SA et al (2003) Rapid reversible changes to multiple levels of the human somatosensory system following the cessation of repetitive contractions: a somatosensory evoked potential study. Clin Neurophysiol 114(8):1531–1537CrossRefPubMed
24.
go back to reference Taylor HH, Murphy B (2008) Altered sensorimotor integration with cervical spine manipulation. J Manipulative Physiol Ther 31:115–126CrossRefPubMed Taylor HH, Murphy B (2008) Altered sensorimotor integration with cervical spine manipulation. J Manipulative Physiol Ther 31:115–126CrossRefPubMed
25.
go back to reference Haavik-Taylor H, Murphy B (2010) The effects of spinal manipulation on central integration of dual somatosensory input observed after motor training: a crossover study. J Manipulative Physiol Ther 33(4):261–272CrossRefPubMed Haavik-Taylor H, Murphy B (2010) The effects of spinal manipulation on central integration of dual somatosensory input observed after motor training: a crossover study. J Manipulative Physiol Ther 33(4):261–272CrossRefPubMed
26.
go back to reference Morningstar MW, Pettibon BR, Schlappi H et al (2005) Reflex control of the spine and posture: a review of the literature from a chiropractic perspective. Chiropr Osteopat 13:16CrossRefPubMedCentralPubMed Morningstar MW, Pettibon BR, Schlappi H et al (2005) Reflex control of the spine and posture: a review of the literature from a chiropractic perspective. Chiropr Osteopat 13:16CrossRefPubMedCentralPubMed
27.
go back to reference Diab A (2012) The role of forward head correction in management of adolescent idiopathic scoliotic patients: a randomized controlled trial. Clin Rehabil 26:1123–1132CrossRefPubMed Diab A (2012) The role of forward head correction in management of adolescent idiopathic scoliotic patients: a randomized controlled trial. Clin Rehabil 26:1123–1132CrossRefPubMed
28.
go back to reference Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 33:160–172CrossRefPubMed Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum 33:160–172CrossRefPubMed
29.
go back to reference Schaefer C, Chandran A, Hufstader M et al (2011) The comparative burden of mild, moderate and severe fibromyalgia: results from a cross-sectional survey in the United States. Health Qual Life Outcomes 9:71CrossRefPubMedCentralPubMed Schaefer C, Chandran A, Hufstader M et al (2011) The comparative burden of mild, moderate and severe fibromyalgia: results from a cross-sectional survey in the United States. Health Qual Life Outcomes 9:71CrossRefPubMedCentralPubMed
30.
go back to reference Ogince M, Hall T, Robinson K, Blackmore AM (2007) The diagnostic validity of the cervical flexion-rotation test in C1/2-related cervicogenic head-ache. Man Ther 12:256–262CrossRefPubMed Ogince M, Hall T, Robinson K, Blackmore AM (2007) The diagnostic validity of the cervical flexion-rotation test in C1/2-related cervicogenic head-ache. Man Ther 12:256–262CrossRefPubMed
31.
go back to reference Luciano JV, Martinez N, Penarrubia-Maria MT et al (2011) Effectiveness of a psychoeducational treatment programme implemented in general practice for fibromyalgia patients: a randomized controlled trial. Clin J Pain 27(5):383–391CrossRefPubMed Luciano JV, Martinez N, Penarrubia-Maria MT et al (2011) Effectiveness of a psychoeducational treatment programme implemented in general practice for fibromyalgia patients: a randomized controlled trial. Clin J Pain 27(5):383–391CrossRefPubMed
32.
go back to reference Turk DC, Meichenbaum D, Genest M (1983) Pain and behavioral medicine: a cognitive-behavioral perspective. Guilford, New York Turk DC, Meichenbaum D, Genest M (1983) Pain and behavioral medicine: a cognitive-behavioral perspective. Guilford, New York
33.
go back to reference Ost L (1987) Applied relaxation: description of a coping technique and review of controlled studies. Behav Res Ther 25:397–409CrossRefPubMed Ost L (1987) Applied relaxation: description of a coping technique and review of controlled studies. Behav Res Ther 25:397–409CrossRefPubMed
34.
go back to reference Maitland GD, Hengeveld E, Banks K et al (2000) Maitland’s vertebral manipulation, 6th edn. Butterworth, London Maitland GD, Hengeveld E, Banks K et al (2000) Maitland’s vertebral manipulation, 6th edn. Butterworth, London
35.
go back to reference Srifi N, Bahiri R, Rostom S et al (2013) The validity and reliability of the Moroccan version of the Revised Fibromyalgia Impact Questionnaire. Rheumatol Int 33:179–183CrossRefPubMed Srifi N, Bahiri R, Rostom S et al (2013) The validity and reliability of the Moroccan version of the Revised Fibromyalgia Impact Questionnaire. Rheumatol Int 33:179–183CrossRefPubMed
36.
go back to reference Lippold C, Danesh G, Hoppe G et al (2007) Trunk inclination, pelvic tilt and Pelvic rotation in relation to the craniofacial morphology in adult. Angle Orthod 77:29–35CrossRefPubMed Lippold C, Danesh G, Hoppe G et al (2007) Trunk inclination, pelvic tilt and Pelvic rotation in relation to the craniofacial morphology in adult. Angle Orthod 77:29–35CrossRefPubMed
37.
go back to reference Campbell CM, McCauley L, Bounds SC et al (2012) Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing. Arthritis Res Ther 14:R231CrossRefPubMedCentralPubMed Campbell CM, McCauley L, Bounds SC et al (2012) Changes in pain catastrophizing predict later changes in fibromyalgia clinical and experimental pain report: cross-lagged panel analyses of dispositional and situational catastrophizing. Arthritis Res Ther 14:R231CrossRefPubMedCentralPubMed
38.
go back to reference Tastekin N, Uzunca K, Sut N et al (2010) Discriminative value of tender points in fibromyalgia syndrome. Pain Med 11:466–471CrossRefPubMed Tastekin N, Uzunca K, Sut N et al (2010) Discriminative value of tender points in fibromyalgia syndrome. Pain Med 11:466–471CrossRefPubMed
39.
go back to reference Buysse DJ, Reynolds CF, Monk TH et al (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213CrossRefPubMed Buysse DJ, Reynolds CF, Monk TH et al (1989) The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213CrossRefPubMed
40.
go back to reference Beck AK, Epstein N, Brown G et al (1988) An inventory for measuring clinical anxiety: psychometrics properties. J Consult Clin Psychol 56:893–897CrossRefPubMed Beck AK, Epstein N, Brown G et al (1988) An inventory for measuring clinical anxiety: psychometrics properties. J Consult Clin Psychol 56:893–897CrossRefPubMed
41.
go back to reference Beck AT, Ward CH, Mendelson M et al (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571CrossRefPubMed Beck AT, Ward CH, Mendelson M et al (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571CrossRefPubMed
42.
go back to reference Bennett RM, Bushmakin AG, Cappelleri JC et al (2009) Minimal clinically important difference in the fibromyalgia impact questionnaire. J Rheumatol 36:1304–1311CrossRefPubMed Bennett RM, Bushmakin AG, Cappelleri JC et al (2009) Minimal clinically important difference in the fibromyalgia impact questionnaire. J Rheumatol 36:1304–1311CrossRefPubMed
43.
go back to reference Ledin T, Hafstrom A, Fransson PA et al (2003) Influence of neck proprioception on vibration-induced postural sway. Acta Otolaryngol 123:594–599CrossRefPubMed Ledin T, Hafstrom A, Fransson PA et al (2003) Influence of neck proprioception on vibration-induced postural sway. Acta Otolaryngol 123:594–599CrossRefPubMed
44.
go back to reference Karnath HO, Konczak J, Dichgans J (2000) Effect of prolonged neck muscle vibration on lateral head tilt in severe spasmodic torticollis. J Neurol Neurosurg Psychiatry 69:658–660CrossRefPubMedCentralPubMed Karnath HO, Konczak J, Dichgans J (2000) Effect of prolonged neck muscle vibration on lateral head tilt in severe spasmodic torticollis. J Neurol Neurosurg Psychiatry 69:658–660CrossRefPubMedCentralPubMed
45.
go back to reference Zhu Y, Haldeman S, Starr A et al (1993) Paraspinal muscle evoked cerebral potentials in patients with unilateral low back pain. Spine 18(8):1096–1102CrossRefPubMed Zhu Y, Haldeman S, Starr A et al (1993) Paraspinal muscle evoked cerebral potentials in patients with unilateral low back pain. Spine 18(8):1096–1102CrossRefPubMed
46.
go back to reference Zhu Y, Haldeman S, Hsieh C-YJ et al (2000) Do cerebral potentials to magnetic stimulation of paraspinal muscles reflect changes in palpable muscle spasm, low back pain, and activity scores? J Manipulative Physiol Ther 232(7):458–464CrossRef Zhu Y, Haldeman S, Hsieh C-YJ et al (2000) Do cerebral potentials to magnetic stimulation of paraspinal muscles reflect changes in palpable muscle spasm, low back pain, and activity scores? J Manipulative Physiol Ther 232(7):458–464CrossRef
47.
go back to reference Harrison DE, Harrison DD, Janik TJ (2001) Comparison of axial and flexural stresses in lordosis and three buckled configurations of the cervical spine. Clin Biomech (Bristol, Avon) 16:276–278CrossRef Harrison DE, Harrison DD, Janik TJ (2001) Comparison of axial and flexural stresses in lordosis and three buckled configurations of the cervical spine. Clin Biomech (Bristol, Avon) 16:276–278CrossRef
48.
go back to reference Diab AA, Moustafa IM (2012) The efficacy of forward head correction on nerve root function and pain in cervical spondylotic radiculopathy: a randomized trial. Clin Rehabil 26:351–361CrossRefPubMed Diab AA, Moustafa IM (2012) The efficacy of forward head correction on nerve root function and pain in cervical spondylotic radiculopathy: a randomized trial. Clin Rehabil 26:351–361CrossRefPubMed
49.
go back to reference Mannerkorpi K, Ahlmen M, Ekdahl C (2002) Six- and 24-month follow-up of pool exercise therapy and education for patients with fibromyalgia. Scand J Rheumatol 31:306–310CrossRefPubMed Mannerkorpi K, Ahlmen M, Ekdahl C (2002) Six- and 24-month follow-up of pool exercise therapy and education for patients with fibromyalgia. Scand J Rheumatol 31:306–310CrossRefPubMed
50.
go back to reference King SJ, Wessel J, Bhambhani Y et al (2002) The effects of exercise and education, individually or combined, in women with fibromyalgia. J Rheumatol 29:2620–2627PubMed King SJ, Wessel J, Bhambhani Y et al (2002) The effects of exercise and education, individually or combined, in women with fibromyalgia. J Rheumatol 29:2620–2627PubMed
51.
go back to reference Koulil SV (2007) Cognitive-behavioural therapies and exercise program for patients with fibromyalgia: state of the art and future directions. Ann Rheum Dis 66:571–581CrossRefPubMedCentralPubMed Koulil SV (2007) Cognitive-behavioural therapies and exercise program for patients with fibromyalgia: state of the art and future directions. Ann Rheum Dis 66:571–581CrossRefPubMedCentralPubMed
52.
go back to reference Häuser W, Bernardy K, Arnold B et al (2009) Efficacy of multicomponent treatment in fibromyalgia syndrome: a meta-analysis of randomized controlled clinical trials. Arthritis Rheum 61:216–224CrossRefPubMed Häuser W, Bernardy K, Arnold B et al (2009) Efficacy of multicomponent treatment in fibromyalgia syndrome: a meta-analysis of randomized controlled clinical trials. Arthritis Rheum 61:216–224CrossRefPubMed
53.
go back to reference Dolphens M, Cagnie B, Coorevits P et al (2012) Sagittal standing posture and its association with spinal pain: a school-based epidemiological study of 1196 Flemish adolescents before age at peak height velocity. Spine (Phila Pa 1976) 37:1657–1666CrossRef Dolphens M, Cagnie B, Coorevits P et al (2012) Sagittal standing posture and its association with spinal pain: a school-based epidemiological study of 1196 Flemish adolescents before age at peak height velocity. Spine (Phila Pa 1976) 37:1657–1666CrossRef
54.
go back to reference Travell JG, Simons D (1973) Myofascial pain and dysfunction: the trigger point manual. Williams & Wilkins, Philadelphia Travell JG, Simons D (1973) Myofascial pain and dysfunction: the trigger point manual. Williams & Wilkins, Philadelphia
55.
go back to reference Seaman DR, Winterstein JF (1998) Dysafferentation: a novel term to describe the neuropathophysiological effects of joint complex dysfunction. A look at likely mechanisms of symptom generation. J Manipulative Physiol Ther 21:267–280PubMed Seaman DR, Winterstein JF (1998) Dysafferentation: a novel term to describe the neuropathophysiological effects of joint complex dysfunction. A look at likely mechanisms of symptom generation. J Manipulative Physiol Ther 21:267–280PubMed
Metadata
Title
The addition of upper cervical manipulative therapy in the treatment of patients with fibromyalgia: a randomized controlled trial
Authors
Ibrahim M. Moustafa
Aliaa A. Diab
Publication date
01-07-2015
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 7/2015
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-015-3248-7

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