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Open Access 01-05-2013 | Original Article

Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus

Authors: Piotr Piotrowski, Margarita Lianeri, Mariusz Wudarski, Marzena Olesińska, Paweł P. Jagodziński

Published in: Rheumatology International | Issue 5/2013

Abstract

There are several studies on the association of TLR9 polymorphisms with systemic lupus erythematosus (SLE) in different ethnicities; however, the results are inconsistent. Therefore, we studied the distribution of the TLR9 C > T (rs352140) polymorphism in patients with SLE (n = 254) and controls (n = 521) in a Polish population. We did not observe significant differences in the prevalence of the TLR9 C > T genotype and alleles between patients with SLE and controls. However, we found a contribution of the T/T and T/C genotypes to renal [OR = 2.949 (95 % CI = 1.523–5.711, p = 0.001), (p _corr = 0.017)] and immunologic disorders [OR = 2.938 (95 % CI 1.500–5.755, p = 0.0012), (p _corr = 0.0204)] in SLE patients. Moreover, we observed a significant association between the TLR9 T/T and T/C genotypes and the presence of anti-dsDNA Ab [OR = 3.682 (1.647–8.230, p = 0.001), (p _corr = 0.017)]. Our studies suggest that the TLR9 C > T (rs352140) polymorphism might contribute to renal and immunologic disorders and to the presence of anti-dsDNA Ab.

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Title: Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus
Authors: Piotr Piotrowski
Margarita Lianeri
Mariusz Wudarski
Marzena Olesińska
Paweł P. Jagodziński
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 5/2013
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-012-2509-y

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