Top

Published in:

01-06-2013 | Short Communication

Serum ghrelin in female patients with rheumatoid arthritis during treatment with infliximab

Authors: Michal Magiera, Magdalena Kopec-Medrek, Małgorzata Widuchowska, Anna Kotulska, Tomasz Dziewit, Damian Ziaja, Eugene J. Kucharz, Beata Logiewa-Bazger, Wlodzimierz Mazur

Published in: Rheumatology International | Issue 6/2013

Abstract

Ghrelin is a gastric hormone that posses multiple functions, including induction of growth hormone release, regulation of proinflammatory cytokines and control of food intake and energy homeostasis. A few reports on serum ghrelin level in chronic inflammatory states revealed contradictory results. The study was undertaken to determine ghrelin in patients with rheumatoid arthritis receiving infliximab, a TNF-α blocking agent. Serum ghrelin was determined in 18 female rheumatoid patients before the treatment with infliximab, 1 week after the first infusion and after 53 weeks of medication and compared with 15 age-matched healthy women. Serum ghrelin level was shown to be increased in the patients. A decrease in serum ghrelin level was found after the first infusion of infliximab and similarly decreased ghrelin level but still higher than in the control was shown in the 53rd week of medication. The obtained results suggest that ghrelin level is related to inflammation, and its serum level in patients with severe rheumatoid arthritis behaves similarly to acute-phase reactants.

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656–660CrossRef

Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF et al (2000) Preliminary evidence that ghrelin, the natural GH secretagogue-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 23:493–495CrossRef

Gualilo O, Lago F, Gómez-Reino J, Casanueva FF, Dieguez C (2003) Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action. FEBS Lett 552:105–109CrossRef

Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M (2000) Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 275:477–480CrossRef

Nakazato M, Murkami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194–198CrossRef

Nagaya N, Vematsu M, Kojima M (2001) Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationship between ghrelin and anabolic/catabolic factors. Circulation 104:2034–2038CrossRef

Yilmaz E, Ustundag B, Sen Y, Akarsu S, Kurt ANC, Dogan Y (2007) The level of ghrelin, TNF-α, and IL-6 in children with cyanotic and acyanotic congenital heart disease. Mediators Inflamm 2007:32403CrossRef

Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908–913CrossRef

Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K et al (2001) Ghrelin, an endogenous growth hormone secretagogoue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50:227–232CrossRef

10.

Wu R, Dong W, Cui X, Zhon M, Simms HH, Ravikumart TS, Wang P (2007) Ghrelin down-regulates proinflammatory cytokines in sepsic through activation of the vagus nerve. Ann Surg 245:480–486CrossRef

11.

Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll L et al (2004) Ghrelin inhibits proinflammatory responses and nuclear factor-kappa B activation in human endothelial cells. Circulation 109:2221–2226CrossRef

12.

Furst DE, Keystone EC, Kirkham B, Kavanaugh A, Fleischmann R, Mease P et al (2008) Updated consensus statement on biological agents for the treatment of rheumatic disease 2008. Ann Rheum Dis 67(suppl 3):iii2–iii25CrossRef

13.

Otero M, Nogueiras R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O (2004) Chronic inflammation modulates ghrelin levels in human and rats. Rheumatology 43:306–310CrossRef

14.

Gonzalez-Gay MA, Garcia-Unzueta MT, Berja A, Vazquez-Rodriguez TR, Gonzalez-Juanatey C, de Matias JM et al (2008) Anti-tumor necrosis factor α therapy modulates ghrelin in patients with severe rheumatoid arthritis. Ann Rheum Dis 67:1644–1646CrossRef

15.

Maruna P, Gürlich R, Rosická M (2008) Ghrelin as an acute-phase reactant during postoperative stress response. Hum Metab Res 40:404–409CrossRef

16.

Kümpers P, Horm R, Brabant G, Woywodt A, Schiffer M, Haller H, Haubitz M (2008) Serum lepitn and ghrelin correlate with disease activity in ANCA-associated vasculitis. Rheumatology 47:484–487CrossRef

17.

Dixit VD, Schaffer EM, Pyle RS, Collins GD, Sakthivel SK, Palaniappan R et al (2004) Ghrelin inhibit leptin—and activation-induced proinflammatory cytokines expression by human monocytes and T-cells. J Clin Invest 114:57–66CrossRef

Title: Serum ghrelin in female patients with rheumatoid arthritis during treatment with infliximab
Authors: Michal Magiera
Magdalena Kopec-Medrek
Małgorzata Widuchowska
Anna Kotulska
Tomasz Dziewit
Damian Ziaja
Eugene J. Kucharz
Beata Logiewa-Bazger
Wlodzimierz Mazur
Publication date: 01-06-2013
Publisher: Springer Berlin Heidelberg
Published in: Rheumatology International / Issue 6/2013
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-011-2262-7

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Serum ghrelin in female patients with rheumatoid arthritis during treatment with infliximab

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2013

Triple DMARD combination for rheumatoid arthritis resistant to methotrexate and steroid combination: a single-center experience

Arachnoid ossificans of thoracolumbosacral spine in the advanced ankylosing spondylitis: a case report

Sexual activity in Moroccan men with ankylosing spondylitis

About the manuscript Arıca et al

Effect of cyclophosphamide on cytokines in patients with primary Sjögren’s syndrome-associated interstitial lung disease in South China

A primary analysis of sexual problems in Chinese patients with ankylosing spondylitis

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page