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01-08-2012 | Short Communication

Evaluation of lower limb disability in joint hypermobility syndrome

Authors: Claudia Celletti, Marco Castori, Paola Grammatico, Filippo Camerota

Published in: Rheumatology International | Issue 8/2012

Abstract

The aim of this study is to evaluate degree and possible major determinants of lower limb disability in joint hypermobility syndrome. Forty patients with joint hypermobility syndrome were studied. Lower limb function was evaluated with the lower limb functional scale (LEFS). Intensity of pain was estimated by the numeric rating scale. Rough results were compared with previously published data for osteoarthritis patients. Within the studied population, comparisons were performed by age, sex, numeric rating scale and Beighton scores. In joint hypermobility syndrome, LEFS score was similar to osteoarthritis, but in the former, comparable values were observed with a ~10 year earlier onset. LEFS scores resulted significantly related to age, pain intensity and Beighton score. No correlation with sex was observed. This study demonstrated that, in joint hypermobility syndrome, disability of lower limbs is remarkable and related to the increase in pain and age and to the decrease in residual joint hypermobility. These preliminary results may be relevant for the identification of more efficient and tailored treatment programs.

Grahame R (2010) What is the joint hypermobility syndrome? JHS from the cradle to the grave In: Hakim AJ, Keer R, Grahame R (eds) Hypermobility, fibromyalgia and chronic pain. Edimburgh, United Kingdom: Chirchill Livingstone Elsevier, p 61–68

Tinkle BT, Bird HA, Grahame R, Lavallee M, Levy HP, Sillence D (2009) The lack of clinical distinction between the hypermobility type of Ehlers-Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome). Am J Med Genet A. 149A(11):2368–2370PubMedCrossRef

Castori M, Camerota F, Celletti C, Grammatico P, Padua L (2010) Quality of life in the classic and hypermobility types of Ehlers-Danlos syndrome. Ann Neurol 67(1):145–146PubMedCrossRef

Voermans NC, Knoop H (2010) Both pain and fatigue are important possible determinants of disability in patients with the Ehlers-Danlos syndrome hypermobility type. Disabil Rehabil (in press)

Berglund B, Nordstrom G, Hagberg C, Mattiason A (2005) Foot pain and disability in individuals with Ehlers-Danlos syndrome (EDS): impact on daily life activities. Disabil Rehabil 27(4):164–169PubMedCrossRef

Sahin N, Baskent A, Cakmak A, Salli A, Ugurlu H, Berker E (2008) Evaluation of knee proprioception and effects of proprioception exercise in patients with benign joint hypermobility syndrome. Rheumatol Int 28(10):995–1000PubMedCrossRef

Cacchio A, De Blasis E, Necozione S, Rosa F, Riddle DL, di Orio F, De Blasis D, Santilli V (2010) The Italian version of the lower extremity functional scale was reliable, valid, and responsive. J Clin Epidemiol 63(5):550–557PubMedCrossRef

Pua Y, Cowan S, Wrigley T, Bennell (2009) The lower extremity functional scale could be an alternative to the Western Ontario and McMaster universities osteoarthritis index physical function scale. J Clin Epidemiol 62(10):1103–1111PubMedCrossRef

Robbins SM, Clark JM, Maly MR (2011) Longitudinal gait and strength changes prior to and following an anterior cruciate ligament rupture and surgical reconstruction: a case report. J Orthop Sports Phys Ther (in press)

10.

Fukuda TY, Rossetto FM, Magalhães E, Bryk FF, Lucareli PR, de Almeida Aparecida Carvalho N (2010) Short-term effects of hip abductors and lateral rotators strengthening in females with patellofemoral pain syndrome: a randomized controlled clinical trial. J Orthop Sports Phys Ther 40(11):736–742PubMed

11.

Beighton P, Solomon L, Soskolne CL (1973) Articular mobility in an African population. Ann Rheum Dis 32(5):413–418PubMedCrossRef

12.

Hakim AJ, Grahame R (2003) A simple questionnaire to detect hypermobility: an adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract 57(3):163–166PubMed

13.

Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ (1998) Ehlers-Danlos syndromes: revised nosology, Villefranche,1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med Genet 77(1):31–37PubMedCrossRef

14.

Grahame R, Bird HA, Child A (2000) The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 27(7):1777–1779PubMed

15.

Binkley JM, Stratford PW, Lott SA, Riddle DL (1999) The lower extremity functional scale (LEFS): scale development, measurement properties, and clinical application. North American orthopaedic rehabilitation research network. Phys Ther 79(4):371–383PubMed

16.

Downie WW, Leatham PA, Rhind VM, Wright V, Branco JA, Andreson JA (1978) Studies with pain rating scale. Ann Rheum Dis 37(4):378–381PubMedCrossRef

17.

Bridges AJ, Smith E, Reid J (1992) Joint hypermobility in adults referred to rheumatology clinics. Ann Rheum Dis 51(6):793–796PubMedCrossRef

18.

George M, Bankes MJK (2010) The hip joint. In: Hakim AJ, Keer R, Grahame R (eds) Hypermobility, fibromyalgia and chronic pain. Elsevier, Edimburgh, pp 217–223

19.

Haddad F, Dhawan R (2010) The knee joint. In: Hakim AJ, Keer R, Grahame R (eds) Hypermobility, fibromyalgia and chronic pain. Elsevier, Edimburgh, pp 224–231

20.

McCullach RS, Redmond A (2010) The hypermobile foot. In: Hakim AJ, Keer R, Grahame R (eds) Hypermobility, Fibromyalgia and Chronic Pain. Elsevier, Edimburgh, pp 232–244

21.

Dolan AL, Hart DJ, Doyle DV, Grahame R, Spector TD (2003) The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: the Chingford Study. J Rheumatol 30(4):799–803PubMed

22.

Hakim AJ, Sahota A (2006) Joint hypermobility and skin elasticity: the hereditary disorders of connective tissue. Clin Dermatol 24(6):521–533PubMedCrossRef

23.

Rabenda V, Manette C, Lemmens R, Mariani AM, Struvay N, Reginster JY (2006) Direct and indirect costs attributable to osteoarthritis in active subjects. J Rheumatol 33(6):1152–1158PubMed

24.

Voermans NC, Knoop H, Bleijenberg G, van Engelen BG (2010) Pain in ehlers-danlos syndrome is common, severe, and associated with functional impairment. J Pain Symptom Manage 40(3):370–378PubMedCrossRef

25.

Castori M, Camerota F, Celletti C, Danese C, Santilli V, Saraceni VM, Grammatico P (2010) Natural history and manifestations of the hypermobility type Ehlers-Danlos syndrome: a pilot study on 21 patients. Am J Med Genet A 152A(3):556–564PubMedCrossRef

26.

Keer R, Simmonds J (2011) Joint protection and physical rehabilitation of the adult with hypermobility syndrome. Curr Opin Rheumatol 23(2):131–136PubMedCrossRef

27.

Camerota F, Celletti C, Castori M, Grammatico P, Padua L (2010) Neuropathic pain is a common feature in ehlers-danlos syndrome. J Pain Symptom Manage (in press)

Title: Evaluation of lower limb disability in joint hypermobility syndrome
Authors: Claudia Celletti
Marco Castori
Paola Grammatico
Filippo Camerota
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 8/2012
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-011-2044-2

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