Skip to main content
Top
Published in: Rheumatology International 11/2010

01-09-2010 | Review

Fibromyalgia and nutrition, what do we know?

Authors: Laura-Isabel Arranz, Miguel-Ángel Canela, Magda Rafecas

Published in: Rheumatology International | Issue 11/2010

Login to get access

Abstract

Many people suffer from fibromyalgia (FM) without an effective treatment. They do not have a good quality of life and cannot maintain normal daily activity. Among the different hypotheses for its ethiopathophysiology, oxidative stress is one of the possibilities. Non-scientific information addressed to patients regarding the benefits of nutrition is widely available, and they are used to trying non-evidenced strategies. The aim of this paper is to find out what we know right now from scientific studies regarding fibromyalgia disease and nutritional status, diets and food supplements. A systematic search has been performed on Medline with a wide range of terms about these nutritional issues. The search has been made during 2009, for articles published between 1998 and 2008. Target population: people suffering from FM. Vegetarian diets could have some beneficial effects probably due to the increase in antioxidant intake. There is a high prevalence of obesity and overweight in patients, and weight control seems to be an effective tool to improve the symptoms. Some nutritional deficiencies have been described, it is not clear whether they are directly related to this disease or not. About the usefulness of some food supplements we found very little data, and it seems that more studies are needed to prove which ones could be of help. Dietary advice is necessary to these patients to improve their diets and maintain normal weight. It would be interesting to investigate more in the field of nutrition and FM to reveal any possible relationships.
Literature
1.
go back to reference Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum 33:160–172CrossRefPubMed Wolfe F, Smythe HA, Yunus MB et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum 33:160–172CrossRefPubMed
2.
go back to reference Weir P, Harlan G, Nkoy F et al (2006) The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th revision codes. J Clin Rheumatol 12:124–128CrossRefPubMed Weir P, Harlan G, Nkoy F et al (2006) The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th revision codes. J Clin Rheumatol 12:124–128CrossRefPubMed
3.
go back to reference Maquet D, Croisier JL, Crielaard JM (2000) Fibromyalgia in the year. Rev Med Liege 55(11):991–997PubMed Maquet D, Croisier JL, Crielaard JM (2000) Fibromyalgia in the year. Rev Med Liege 55(11):991–997PubMed
4.
go back to reference Lawrence R, Helmick C, Arnett F et al (1998) Estimates of the prevalence of artritis and selected músculoskeletal disorders in the United States. Artritis Rheum 41:778–799CrossRef Lawrence R, Helmick C, Arnett F et al (1998) Estimates of the prevalence of artritis and selected músculoskeletal disorders in the United States. Artritis Rheum 41:778–799CrossRef
5.
go back to reference Wolfe F, Ross K, Anderson J et al (1995) The prevalence and characteristics of fibromyalgia in the general population. Artritis Rheum 38:19–28CrossRef Wolfe F, Ross K, Anderson J et al (1995) The prevalence and characteristics of fibromyalgia in the general population. Artritis Rheum 38:19–28CrossRef
6.
go back to reference White KP, Speedchley M, Harth M et al (1999) The London fibromyalgia epidemiology study: the prevalence of fibromyalgia syndrome in London, Ontario. J Rheumatol 26(7):1570–1576PubMed White KP, Speedchley M, Harth M et al (1999) The London fibromyalgia epidemiology study: the prevalence of fibromyalgia syndrome in London, Ontario. J Rheumatol 26(7):1570–1576PubMed
7.
go back to reference White KP, Harth M (2001) Classification, epidemiology, and natural history of fibromyalgia. Curr Pain Headache Rep 5(4):320–329CrossRefPubMed White KP, Harth M (2001) Classification, epidemiology, and natural history of fibromyalgia. Curr Pain Headache Rep 5(4):320–329CrossRefPubMed
8.
go back to reference Valverde M, Juan A, Ribas B et al (2000) Prevalencia de la fibromialgia en la población española. Estudio EPISER 2000. Rev Esp Reumatol 27(5):157 Valverde M, Juan A, Ribas B et al (2000) Prevalencia de la fibromialgia en la población española. Estudio EPISER 2000. Rev Esp Reumatol 27(5):157
9.
go back to reference Carmona L, Ballina J, Gabriel R et al (2001) EPISER study group. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey. Ann Rheum Dis 60(11):1040–1045 Carmona L, Ballina J, Gabriel R et al (2001) EPISER study group. The burden of musculoskeletal diseases in the general population of Spain: results from a national survey. Ann Rheum Dis 60(11):1040–1045
10.
go back to reference Mas AJ, Carmona L, Valverde M et al (2008) EPISER study group. Prevalence and impact of fibromyalgia on function and quality of life in individuals from the general population results from a nationwide study in Spain. Clin Exp Rheumatol 26(4):519–526 Mas AJ, Carmona L, Valverde M et al (2008) EPISER study group. Prevalence and impact of fibromyalgia on function and quality of life in individuals from the general population results from a nationwide study in Spain. Clin Exp Rheumatol 26(4):519–526
11.
go back to reference Gamero F, Gabriel R, Carbonell J et al (2005) Pain in Spanish rheumatology outpatient offices: EPIDOR epidemiological study. Rev Clin Esp 205:157–163CrossRef Gamero F, Gabriel R, Carbonell J et al (2005) Pain in Spanish rheumatology outpatient offices: EPIDOR epidemiological study. Rev Clin Esp 205:157–163CrossRef
12.
go back to reference Salaffi F, De Angelis R, Gras W et al (2005) Pain prevalence, investigation group (MAPPING) study. Prevalence of musculoskeletal conditions in an Italian population sample: results of a regional community-based study. I. The MAPPING study. Clin Exp Rheumatol 23(6):819–828 Salaffi F, De Angelis R, Gras W et al (2005) Pain prevalence, investigation group (MAPPING) study. Prevalence of musculoskeletal conditions in an Italian population sample: results of a regional community-based study. I. The MAPPING study. Clin Exp Rheumatol 23(6):819–828
13.
go back to reference Bannwarth B, Blotman F, Roué-Le Lay K et al (2008) Fibromyalgia síndrome in the general population of France: a prevalence study. Joint Bone Spine 24. [Epub ahead of print] Bannwarth B, Blotman F, Roué-Le Lay K et al (2008) Fibromyalgia síndrome in the general population of France: a prevalence study. Joint Bone Spine 24. [Epub ahead of print]
14.
go back to reference Felson DT (2008) Comparing the prevalence of rheumatic diseases in China with the rest of the world. Editorial. Arthritis Res Ther 10:106 Felson DT (2008) Comparing the prevalence of rheumatic diseases in China with the rest of the world. Editorial. Arthritis Res Ther 10:106
15.
go back to reference Eisinger J, Plantamura A, Marie PA et al (1994) Selenium and magnesium status in fibromyalgia. Magnes Res 7(3–4):285–288PubMed Eisinger J, Plantamura A, Marie PA et al (1994) Selenium and magnesium status in fibromyalgia. Magnes Res 7(3–4):285–288PubMed
16.
go back to reference Reinhard P, Schweinsberg F, Wernet D et al (1998) Selenium status in fibromyalgia. Toxicol Lett 96–97:177–180CrossRefPubMed Reinhard P, Schweinsberg F, Wernet D et al (1998) Selenium status in fibromyalgia. Toxicol Lett 96–97:177–180CrossRefPubMed
17.
go back to reference Ozgocmen S, Ozyurt H, Sogut S et al (2006) Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia etiologic and therapeutic concerns. Rheumatol Int 26:598–603CrossRefPubMed Ozgocmen S, Ozyurt H, Sogut S et al (2006) Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia etiologic and therapeutic concerns. Rheumatol Int 26:598–603CrossRefPubMed
18.
go back to reference Bagis S, Tamer L, Sahin G et al (2005) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Reumatol Int 25:188–190CrossRef Bagis S, Tamer L, Sahin G et al (2005) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? Reumatol Int 25:188–190CrossRef
19.
go back to reference Altindag O, Celik H (2006) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia. Redox Rep 11(3):131–135CrossRefPubMed Altindag O, Celik H (2006) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia. Redox Rep 11(3):131–135CrossRefPubMed
20.
go back to reference Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83:84–92CrossRefPubMed Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83:84–92CrossRefPubMed
21.
go back to reference Ozgocmen S, Ozyurt H, Sogut S et al (2006) Current concepts in the pathophysilogy of fibromyalgia: the potential role of oxidative stress and nitric oxide. Reumatol Int 26:585–597CrossRef Ozgocmen S, Ozyurt H, Sogut S et al (2006) Current concepts in the pathophysilogy of fibromyalgia: the potential role of oxidative stress and nitric oxide. Reumatol Int 26:585–597CrossRef
22.
go back to reference Pall ML (2001) Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 57(2):139–145CrossRefPubMed Pall ML (2001) Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 57(2):139–145CrossRefPubMed
23.
go back to reference Hänninen O, Kaartinen K, Rauma AL et al (2000) Antioxidants in vegan diet and rheumatic disorders. Toxicology 155:45–53CrossRefPubMed Hänninen O, Kaartinen K, Rauma AL et al (2000) Antioxidants in vegan diet and rheumatic disorders. Toxicology 155:45–53CrossRefPubMed
24.
go back to reference Donaldson MS, Speight N, Loomis S (2001) Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med 1:7CrossRefPubMed Donaldson MS, Speight N, Loomis S (2001) Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med 1:7CrossRefPubMed
25.
go back to reference Vecchiet J, Cipollone F, Falasca K et al (2003) Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Neurosci Lett 335(3):151–154CrossRefPubMed Vecchiet J, Cipollone F, Falasca K et al (2003) Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Neurosci Lett 335(3):151–154CrossRefPubMed
26.
go back to reference Kennedy G, Spence VA, McLaren M et al (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 39:584–589CrossRefPubMed Kennedy G, Spence VA, McLaren M et al (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 39:584–589CrossRefPubMed
27.
go back to reference Richards RS, Wang L, Jelinek H (2007) Erythrocyte oxidative damage in chronic fatigue syndrome. Arch Med Res 38:94–98CrossRefPubMed Richards RS, Wang L, Jelinek H (2007) Erythrocyte oxidative damage in chronic fatigue syndrome. Arch Med Res 38:94–98CrossRefPubMed
28.
go back to reference Zhang Z, Cherryholmes G, Mao A et al (2008) High plasma levels of MCP-1 and Eotaxin provide evidence for an immunological basis of fibromyalgia. Exp Biol Med 2333:1171–1180 Zhang Z, Cherryholmes G, Mao A et al (2008) High plasma levels of MCP-1 and Eotaxin provide evidence for an immunological basis of fibromyalgia. Exp Biol Med 2333:1171–1180
29.
go back to reference Wallace DJ, Linker-Israeli M, Hallegua D et al (2001) Cytokines paly an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology 40:74–749CrossRef Wallace DJ, Linker-Israeli M, Hallegua D et al (2001) Cytokines paly an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology 40:74–749CrossRef
30.
go back to reference Wallace DJ (2006) Is there a role for cytokine based therapies in fibromyalgia. Curr Pharm Des 12(1):17–22CrossRefPubMed Wallace DJ (2006) Is there a role for cytokine based therapies in fibromyalgia. Curr Pharm Des 12(1):17–22CrossRefPubMed
31.
go back to reference Chakrabarty S, Zoorob R (2007) Fibromyalgia. Am Fam Physician 15; 76(2):247–254 Chakrabarty S, Zoorob R (2007) Fibromyalgia. Am Fam Physician 15; 76(2):247–254
32.
go back to reference Carville SF, Arendt-Nielsen S, Bliddal H et al (2008) EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 67:536–541CrossRefPubMed Carville SF, Arendt-Nielsen S, Bliddal H et al (2008) EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Ann Rheum Dis 67:536–541CrossRefPubMed
33.
go back to reference Perrot S, Dickenson AH, Bennett RM (2008) Fibromyalgia: harmonizing science with clinical practice considerations. Pain Practice 8(3):177–189CrossRefPubMed Perrot S, Dickenson AH, Bennett RM (2008) Fibromyalgia: harmonizing science with clinical practice considerations. Pain Practice 8(3):177–189CrossRefPubMed
34.
go back to reference Abeles M, Solitar BM, Pillinger MH et al (2008) Update on fibromyalgia therapy. Am J Med 121:555–561CrossRefPubMed Abeles M, Solitar BM, Pillinger MH et al (2008) Update on fibromyalgia therapy. Am J Med 121:555–561CrossRefPubMed
35.
go back to reference Goldenberg DL, Burckhardt C, Crofford L (2004) Management of fibromyalgia síndrome. JAMA 292(19):2388–2395CrossRefPubMed Goldenberg DL, Burckhardt C, Crofford L (2004) Management of fibromyalgia síndrome. JAMA 292(19):2388–2395CrossRefPubMed
36.
go back to reference Nishishinya MB, Rivera J, Alegre C et al (2006) Intervenciones no farmacológicas y tratamientos alternativos en la fibromialgia. Med Clin 12(8):295–299 Nishishinya MB, Rivera J, Alegre C et al (2006) Intervenciones no farmacológicas y tratamientos alternativos en la fibromialgia. Med Clin 12(8):295–299
37.
go back to reference Kaartinen K, Lami K, Hypen M et al (2000) Vegan diet alleviates fibromyalgia symptoms. Scand J Rheumatol 29(5):308–313CrossRefPubMed Kaartinen K, Lami K, Hypen M et al (2000) Vegan diet alleviates fibromyalgia symptoms. Scand J Rheumatol 29(5):308–313CrossRefPubMed
38.
go back to reference Bennet RM (2002) A raw vegetarian diet for patients with fibromyalgia. Curr Rheumatol Rep 4(4):284 Bennet RM (2002) A raw vegetarian diet for patients with fibromyalgia. Curr Rheumatol Rep 4(4):284
39.
go back to reference Azad KA, Alam MN, Hag SA et al (2000) Vegetarian diet en the treatment of fibromyalgia. Bangladesh Med Res Counc Bull 26(2):41–47PubMed Azad KA, Alam MN, Hag SA et al (2000) Vegetarian diet en the treatment of fibromyalgia. Bangladesh Med Res Counc Bull 26(2):41–47PubMed
40.
go back to reference Michalsen A, Riegert M, Lüdtke R et al (2005) Mediterranean diet or extended fasting’s influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid artritis and fibromyalgia: an observational study. BMC Complement Altern Med 5:22CrossRefPubMed Michalsen A, Riegert M, Lüdtke R et al (2005) Mediterranean diet or extended fasting’s influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid artritis and fibromyalgia: an observational study. BMC Complement Altern Med 5:22CrossRefPubMed
41.
go back to reference Smith JD, Terpening CM, Schmidt SOF et al (2001) Relief of fibromyalgia symptoms following discontinuation of dietary excitotoxins. Ann Pharmacother 35:702–706CrossRefPubMed Smith JD, Terpening CM, Schmidt SOF et al (2001) Relief of fibromyalgia symptoms following discontinuation of dietary excitotoxins. Ann Pharmacother 35:702–706CrossRefPubMed
42.
go back to reference Geenen R, Janssens EL, Jacobs JWG et al (2004) Dietary glutamate will not affect pain in fibromyalgia. J Rheumatol 31:785–787PubMed Geenen R, Janssens EL, Jacobs JWG et al (2004) Dietary glutamate will not affect pain in fibromyalgia. J Rheumatol 31:785–787PubMed
43.
go back to reference Cairns BE, Svensson P (2005) Dietary glutamate and fibromyalgia. J Rheumatol 32(2):392–393; Author reply 393–394 Cairns BE, Svensson P (2005) Dietary glutamate and fibromyalgia. J Rheumatol 32(2):392–393; Author reply 393–394
44.
go back to reference Cymet TC (2003) A practical approach to fibromyalgia. J Natl Med Assoc 95:278–285PubMed Cymet TC (2003) A practical approach to fibromyalgia. J Natl Med Assoc 95:278–285PubMed
45.
go back to reference Arnold LM, Hudson JI, Keck PE et al (2006) Comorbidity of fibromyalgia and psychiatric disorders. J Clin Psychiatry 67:1219–1225CrossRefPubMed Arnold LM, Hudson JI, Keck PE et al (2006) Comorbidity of fibromyalgia and psychiatric disorders. J Clin Psychiatry 67:1219–1225CrossRefPubMed
46.
go back to reference Javaras KN, Harrison GP, Lalonde JK et al (2008) Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry 69:266–273CrossRefPubMed Javaras KN, Harrison GP, Lalonde JK et al (2008) Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry 69:266–273CrossRefPubMed
47.
go back to reference Bennett RM, Jones J, Turk DC et al (2007) An internet survey of 2, 596 people with fibromyalgia. BMC Musculoskeletal Disorders 8:27CrossRefPubMed Bennett RM, Jones J, Turk DC et al (2007) An internet survey of 2, 596 people with fibromyalgia. BMC Musculoskeletal Disorders 8:27CrossRefPubMed
48.
go back to reference Patucchi E, Fatati G, Puxeddu A et al (2003) Prevalence of fibromyalgia in diabetes mellitus and obesity. Recent Prog Med 94:163–165 Patucchi E, Fatati G, Puxeddu A et al (2003) Prevalence of fibromyalgia in diabetes mellitus and obesity. Recent Prog Med 94:163–165
49.
go back to reference Yunus MB, Arslan S, Aldag JC (2002) Relationship between body mass index and fibromyalgia features. Scand J Rheumatol 31:27–31CrossRefPubMed Yunus MB, Arslan S, Aldag JC (2002) Relationship between body mass index and fibromyalgia features. Scand J Rheumatol 31:27–31CrossRefPubMed
50.
go back to reference Mengshoel AM, Haugen M (2001) Health status in fibromyalgia–a followup study. J Rheumatol 28:2085–2089PubMed Mengshoel AM, Haugen M (2001) Health status in fibromyalgia–a followup study. J Rheumatol 28:2085–2089PubMed
51.
go back to reference Shapiro JR, Anderson DA, Noff-Burg S (2005) A pilot study of the effects of behavioral weight loss treatment on fibromyalgia symptoms. J Psychosom Res 59:275–282CrossRefPubMed Shapiro JR, Anderson DA, Noff-Burg S (2005) A pilot study of the effects of behavioral weight loss treatment on fibromyalgia symptoms. J Psychosom Res 59:275–282CrossRefPubMed
52.
go back to reference Neumann L, Lerner E, Glazer Y et al (2008) A cross-sectional study of the relationship between body mass index and clinical characteristics, tenderness measures, quality of life, and physical functioning in fibromyalgia patients. Clin Rheumatol 27(12):1543–1547CrossRefPubMed Neumann L, Lerner E, Glazer Y et al (2008) A cross-sectional study of the relationship between body mass index and clinical characteristics, tenderness measures, quality of life, and physical functioning in fibromyalgia patients. Clin Rheumatol 27(12):1543–1547CrossRefPubMed
53.
go back to reference Shaver JLF, Wilbur J, Robinson P et al (2006) Women’s health issues with Fibromyalgia syndrome. J Women’s Health 9(15):1035–1045 Shaver JLF, Wilbur J, Robinson P et al (2006) Women’s health issues with Fibromyalgia syndrome. J Women’s Health 9(15):1035–1045
54.
go back to reference Hooper MM, Stellato TA, Hallowell PT et al (2007) Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery. Int J Obes 31:114–120CrossRef Hooper MM, Stellato TA, Hallowell PT et al (2007) Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery. Int J Obes 31:114–120CrossRef
55.
go back to reference Ananda A, Caterson I, Sambrook P et al (2008) The impact of obesity on the musculoskeletal system. Int J Obes 32(2):211–222CrossRef Ananda A, Caterson I, Sambrook P et al (2008) The impact of obesity on the musculoskeletal system. Int J Obes 32(2):211–222CrossRef
56.
go back to reference Lowe JC, Yellin J, Honeyman-Lowe G (2006) Female fibromyalgia patients: lower resting metabolic rates than matched healthy controls. Med Sci Monit 12(7):CR282-9 Lowe JC, Yellin J, Honeyman-Lowe G (2006) Female fibromyalgia patients: lower resting metabolic rates than matched healthy controls. Med Sci Monit 12(7):CR282-9
57.
go back to reference Loevinger B, Muller D, Alonso C et al (2007) Metabolic syndrome in women with chronic pain. Metab Clin Exp 56:87–93PubMed Loevinger B, Muller D, Alonso C et al (2007) Metabolic syndrome in women with chronic pain. Metab Clin Exp 56:87–93PubMed
58.
go back to reference Verheesen RH, Schweitzer CM (2008) Iodine deficiency, more than cretinism and goiter. Med Hypotheses 71:645–648CrossRefPubMed Verheesen RH, Schweitzer CM (2008) Iodine deficiency, more than cretinism and goiter. Med Hypotheses 71:645–648CrossRefPubMed
59.
go back to reference Pamuk GE, Pamuk ON, Set T et al (2008) An increased prevalence of fibromyalgia in iron deficiency anemia and thalassemia minor and associated factors. Clin Rheumatol 27:1103–1108CrossRefPubMed Pamuk GE, Pamuk ON, Set T et al (2008) An increased prevalence of fibromyalgia in iron deficiency anemia and thalassemia minor and associated factors. Clin Rheumatol 27:1103–1108CrossRefPubMed
60.
go back to reference Swezey RL, Adams J (1999) Fibromyalgia: a risk factor for osteoporosis. J Rheumatol 26(12):2642–2644PubMed Swezey RL, Adams J (1999) Fibromyalgia: a risk factor for osteoporosis. J Rheumatol 26(12):2642–2644PubMed
61.
go back to reference Al-Allaf AW, Mole PA, Paterson CR et al (2003) Bone health in patients with fibromyalgia. Rheumatology 42:1202–1206CrossRefPubMed Al-Allaf AW, Mole PA, Paterson CR et al (2003) Bone health in patients with fibromyalgia. Rheumatology 42:1202–1206CrossRefPubMed
62.
go back to reference Plotnikoff GA, Quigley JM (2003) Prevalence of severe hipovitaminosis D in patients with persistent nonspecific musculoskeletal pain. Mayo Clin Proc 78:1463–1470CrossRefPubMed Plotnikoff GA, Quigley JM (2003) Prevalence of severe hipovitaminosis D in patients with persistent nonspecific musculoskeletal pain. Mayo Clin Proc 78:1463–1470CrossRefPubMed
63.
go back to reference Block SR (2004) Vitamin D deficiency is not associated with nonspecific musculoskeletal pain syndromes including fibromyalgia. Mayo Clin Proc 79(12):1585–1591CrossRefPubMed Block SR (2004) Vitamin D deficiency is not associated with nonspecific musculoskeletal pain syndromes including fibromyalgia. Mayo Clin Proc 79(12):1585–1591CrossRefPubMed
64.
go back to reference Warner AE, Arnspiger SA (2008) Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol 14(1):12–16CrossRefPubMed Warner AE, Arnspiger SA (2008) Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol 14(1):12–16CrossRefPubMed
65.
go back to reference Armstrong DJ, Meenagh GK, Bickle I (2007) Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 26:551–554CrossRefPubMed Armstrong DJ, Meenagh GK, Bickle I (2007) Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol 26:551–554CrossRefPubMed
66.
go back to reference Mouyis M, Ostor AJK, Crisp AJ et al (2008) Hypovitaminosis D among rheumatology outpatients in clinical practice. Rheumatology 47:1348–1351CrossRefPubMed Mouyis M, Ostor AJK, Crisp AJ et al (2008) Hypovitaminosis D among rheumatology outpatients in clinical practice. Rheumatology 47:1348–1351CrossRefPubMed
67.
go back to reference Sendur OF, Tastaba E, Turan Y et al (2008) The relationship between serum trace elements levels and clinical parameters in patients with fibromyalgia. Rheumatol Int 28:1117–1121CrossRefPubMed Sendur OF, Tastaba E, Turan Y et al (2008) The relationship between serum trace elements levels and clinical parameters in patients with fibromyalgia. Rheumatol Int 28:1117–1121CrossRefPubMed
68.
go back to reference Rosborg I, Hyllén E, Lidbeck J et al (2007) Trace element pattern in patients with fibromyalgia. Sci Total Environ 385:20–27CrossRefPubMed Rosborg I, Hyllén E, Lidbeck J et al (2007) Trace element pattern in patients with fibromyalgia. Sci Total Environ 385:20–27CrossRefPubMed
69.
go back to reference Eisinger J, Plantamura A, Marie PA et al (1994) Selenium and magnesium status in fibromyalgia. Magnes Res 7(3–4)–285–288 Eisinger J, Plantamura A, Marie PA et al (1994) Selenium and magnesium status in fibromyalgia. Magnes Res 7(3–4)–285–288
70.
go back to reference Schwarz MJ, Offenbaecher M, Neumeister A et al (2002) Evidence for an altered tryptophan metabolism in fibromyalgia. Neurobiol Dis 11:434–442CrossRefPubMed Schwarz MJ, Offenbaecher M, Neumeister A et al (2002) Evidence for an altered tryptophan metabolism in fibromyalgia. Neurobiol Dis 11:434–442CrossRefPubMed
71.
go back to reference Torpy DJ, Papanicolaou DA, Lotsikas AJ et al (2000) Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6. A pilot study in fibromyalgia. Arthritis and Rheumatism 43(4):872–880 Torpy DJ, Papanicolaou DA, Lotsikas AJ et al (2000) Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6. A pilot study in fibromyalgia. Arthritis and Rheumatism 43(4):872–880
72.
go back to reference Maes M, Verkerk R, Delmeire L et al (2000) Serotoninergic markers and lowered plasma branched-chain-amino acid concentrations in fibromyalgia. Psychiatry Res 97:11–20CrossRefPubMed Maes M, Verkerk R, Delmeire L et al (2000) Serotoninergic markers and lowered plasma branched-chain-amino acid concentrations in fibromyalgia. Psychiatry Res 97:11–20CrossRefPubMed
74.
go back to reference Caruso I, Puttini PS, Cazzola M et al (1990) Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 18:201–209PubMed Caruso I, Puttini PS, Cazzola M et al (1990) Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 18:201–209PubMed
75.
go back to reference Puttini PS, Caruso I (1992) Primary fibromyalgia syndrome and 5-HTP: a 90-day open study. J Int Med Res 20:182–189 Puttini PS, Caruso I (1992) Primary fibromyalgia syndrome and 5-HTP: a 90-day open study. J Int Med Res 20:182–189
76.
go back to reference Nicolodi M, Sicuteri F (1996) Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis therapy. Adv Exp Med Biol 398:373–379PubMed Nicolodi M, Sicuteri F (1996) Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis therapy. Adv Exp Med Biol 398:373–379PubMed
77.
go back to reference Birdsall TC (1998) 5-Hydroxytriptohan: a clinically-effective serotonine precursor. Altern Med Rev 3(4):271–280PubMed Birdsall TC (1998) 5-Hydroxytriptohan: a clinically-effective serotonine precursor. Altern Med Rev 3(4):271–280PubMed
78.
go back to reference Merchant RE, Carmack CA, Wise CM (2000) Nutritional supplementation with chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 14:167–173CrossRefPubMed Merchant RE, Carmack CA, Wise CM (2000) Nutritional supplementation with chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 14:167–173CrossRefPubMed
79.
go back to reference Merchant RE, Andre CA, Wise CM (2001) Nutritional supplementation with chlorella pyrenoidosa for fibromyalgia syndrome: a double-blind, placebo-controlled, crossover study. J Musculoskelet Pain 9(4) Merchant RE, Andre CA, Wise CM (2001) Nutritional supplementation with chlorella pyrenoidosa for fibromyalgia syndrome: a double-blind, placebo-controlled, crossover study. J Musculoskelet Pain 9(4)
80.
go back to reference Merchant RE, Andre CA (2001) A review of recent clinical trials of the nutritional supplement chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med 7(3):79–91PubMed Merchant RE, Andre CA (2001) A review of recent clinical trials of the nutritional supplement chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med 7(3):79–91PubMed
81.
go back to reference Rossini M, Di Munno O, Valentini G et al (2007) Double-blind, multicenter trial comparing acetyl-l-carnitine with placebo in the treatment of fibomyalgia patients. Clin Exp Rheumatol 25(2):182–188PubMed Rossini M, Di Munno O, Valentini G et al (2007) Double-blind, multicenter trial comparing acetyl-l-carnitine with placebo in the treatment of fibomyalgia patients. Clin Exp Rheumatol 25(2):182–188PubMed
82.
go back to reference Lister RE (2002) An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo Biloba extract in Fibromyalgia Syndrome. J Inter Med Res 30:195–199 Lister RE (2002) An open, pilot study to evaluate the potential benefits of coenzyme Q10 combined with Ginkgo Biloba extract in Fibromyalgia Syndrome. J Inter Med Res 30:195–199
83.
go back to reference Olson GB, Savage S, Olson J (2000) The effects of collagen hydrolysat on symptoms of chronic fibromyalgia and temporomandibular joint pain. Cranio 18(2):135–141PubMed Olson GB, Savage S, Olson J (2000) The effects of collagen hydrolysat on symptoms of chronic fibromyalgia and temporomandibular joint pain. Cranio 18(2):135–141PubMed
84.
go back to reference Bramwell B, Ferguson S, Scarlett N et al (2000) The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 5(5):455–462PubMed Bramwell B, Ferguson S, Scarlett N et al (2000) The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev 5(5):455–462PubMed
85.
go back to reference Jacobsen S, Danneskiold-Samsoe B, Andersen RB (1991) Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scand J Rheumatol 20(4):294–302 Jacobsen S, Danneskiold-Samsoe B, Andersen RB (1991) Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scand J Rheumatol 20(4):294–302
86.
go back to reference Fetrow CW, Avila JR (2001) Efficacy of the dietary supplement S-adenosyl-L-methionine. Ann Pharmacother 35:1414–1425CrossRefPubMed Fetrow CW, Avila JR (2001) Efficacy of the dietary supplement S-adenosyl-L-methionine. Ann Pharmacother 35:1414–1425CrossRefPubMed
87.
go back to reference Dykman KD, Tone C, Ford C et al (1998) The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome. Integr Physiol Behav Sci 33(1):61–71 Dykman KD, Tone C, Ford C et al (1998) The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome. Integr Physiol Behav Sci 33(1):61–71
88.
go back to reference Werbach MR (2000) Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 5(2):93–108PubMed Werbach MR (2000) Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 5(2):93–108PubMed
Metadata
Title
Fibromyalgia and nutrition, what do we know?
Authors
Laura-Isabel Arranz
Miguel-Ángel Canela
Magda Rafecas
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 11/2010
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-010-1443-0

Other articles of this Issue 11/2010

Rheumatology International 11/2010 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.