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01-08-2011 | Original Article

Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis

Authors: Hui Yuan, Jin-Dong Ni, Hai-Feng Pan, Lian-Hong Li, Jin-Bao Feng, Dong-Qing Ye

Published in: Rheumatology International | Issue 8/2011

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Fcγ receptor genes have been suggested to play an important role in the pathogenesis of SLE and lupus nephritis (LN). This study aims to assess the association between FcγRIIIb-NA1/NA2 polymorphism and the susceptibility to SLE and lupus nephritis. Relevant studies were identified from electronic databases. A meta-analysis was performed for heterogeneity test and pooled OR calculation. The overall OR of NA2/NA2 homozygous genotype and NA2 allele frequency showed no significant association with SLE and lupus nephritis. Similarly, the association between FcγRIIIb-NA1/NA2 polymorphism and SLE and lupus nephritis was not found in European and Asian population. Taken together, our results suggest that FcγRIIIb might not be a susceptibility gene for SLE and lupus nephritis.

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Title: Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis
Authors: Hui Yuan
Jin-Dong Ni
Hai-Feng Pan
Lian-Hong Li
Jin-Bao Feng
Dong-Qing Ye
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 8/2011
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-010-1386-5

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