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Published in:

01-11-2009 | Original Article

IkBα promoter polymorphisms in patients with ankylosing spondylitis

Authors: Yu-Hung Hung, Tsan-Teng Ou, Chia-Hui Lin, Ruei-Nian Li, Yu-Chih Lin, Wen-Chan Tsai, Hong-Wen Liu, Jeng-Hsien Yen

Published in: Rheumatology International | Issue 1/2009

Abstract

The purpose of this study is to investigate the association of IκBα with the development of ankylosing spondylitis (AS) in Taiwan. One hundred and fifty-four patients with AS and 112 unrelated healthy controls were enrolled in this study. The IκBα-881A/G, -826C/T, -550A/T, -519C/T, and -297C/T polymorphisms were determined by the polymerase chain reaction/restriction fragment length polymorphism method. This study demonstrated that the genotype frequencies of IκBα-826C/T and -826T/T, and allele frequencies of IκBα-826T were significantly higher in the patients with AS than in the controls. We also found that the estimated haplotype frequencies of IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C were significantly increased in the patient with AS in comparison with that of the controls. In contrast, the estimated haplotype frequency of IκBα-881A -826C -550A -519C -297C was significantly decreased in the patients with AS. This study demonstrates that IκBα-826T is associated with the development of AS. Furthermore, the IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C haplotypes are related to susceptibility to AS in Taiwan.

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Title: IkBα promoter polymorphisms in patients with ankylosing spondylitis
Authors: Yu-Hung Hung
Tsan-Teng Ou
Chia-Hui Lin
Ruei-Nian Li
Yu-Chih Lin
Wen-Chan Tsai
Hong-Wen Liu
Jeng-Hsien Yen
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 1/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0923-6

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