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01-11-2009 | Case Report

Chronic catastrophic-like antiphospholipid syndrome: a “smoldering” variant?

Authors: Daniel Athanazio, Maria Cristina Rocha, Túlio Geraldo de Souza e Souza, Natália Oliveira e Silva, Sérgio Jezler, Mittermayer Barreto Santiago

Published in: Rheumatology International | Issue 1/2009

Abstract

Catastrophic antiphospholipid syndrome (CAPS) is characterized by life-threatening diffuse thrombotic manifestations involving particularly small vessels of kidney, lungs, brain and skin. We report a 20-year-old female with systemic lupus erythematosus and secondary antiphospholipid syndrome who presented typical organ and histological involvement as seen in CAPS but with protracted course suggesting a “smoldering” form of the disease.

Santiago M, Martinelli R, Ko A et al (2001) Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar. Clin Exp Rheumatol 19:425–430PubMed

Asherson RA, Cervera R, de Groot PG et al (2003) Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus 12:530–534. doi:10.1191/0961203303lu394oa CrossRefPubMed

Asherson RA, Espinosa G, Menahem S et al (2007) Relapsing catastrophic antiphospholipid syndrome: report of three cases. Semin Arthritis Rheum 37:366–372CrossRefPubMed

Borba EF, Bonfá E, Asherson RA (2005) Catastrophic antiphospholipid syndrome (Asherson’s Syndrome) revealed. Rev Bras Reumatologia 45:374–381

Zamora MR, Warner ML, Tuder R, Schwarz MI (1997) Diffuse alveolar hemorrhage and systemic lupus erythematosus. Clinical presentation, histology, survival, and outcome. Medicine (Baltimore) 76:192–202. doi:10.1097/00005792-199705000-00005 CrossRef

Green RJ, Ruoss SJ, Kraft SA, Duncan SR, Berry GJ, Raffin TA (1996) Pulmonary capillaritis and alveolar hemorrhage. Update on diagnosis and management. Chest 110:1305–1316. doi:10.1378/chest.110.5.1305 CrossRefPubMed

Stojanovich L (2006) Pulmonary manifestations in antiphospholipid syndrome. Autoimmun Rev 5:344–348. doi:10.1016/j.autrev.2006.02.002 CrossRefPubMed

Deane KD, West SG (2005) Antiphospholipid antibodies as a cause of pulmonary capillaritis and diffuse alveolar hemorrhage: a case series and literature review. Semin Arthritis Rheum 35:154–165. doi:10.1016/j.semarthrit.2005.05.006 CrossRefPubMed

Nochy D, Daugas E, Droz D et al (1999) The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J Am Soc Nephrol 10:507–518PubMed

10.

Uthman I, Khamashta M (2006) Antiphospholipid syndrome and the kidneys. Semin Arthritis Rheum 35:360–367. doi:10.1016/j.semarthrit.2006.01.001 CrossRefPubMed

11.

Daugas E, Nochy D, Huong DL et al (2002) Antiphospholipid syndrome nephropathy in systemic lupus erythematosus. J Am Soc Nephrol 13:42–52. doi:10.1159/000049149 PubMed

12.

Khamashta MA, Ruiz-Irastorza G (2006) Management of thrombosis in antiphospholipid syndrome. In: Khamashta MA (ed) Hughes syndrome: antiphospholipid syndrome, 2nd edn. Springer, NY, pp 547–554

Title: Chronic catastrophic-like antiphospholipid syndrome: a “smoldering” variant?
Authors: Daniel Athanazio
Maria Cristina Rocha
Túlio Geraldo de Souza e Souza
Natália Oliveira e Silva
Sérgio Jezler
Mittermayer Barreto Santiago
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 1/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0913-8

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