Treatment outcomes in patients with non-infectious aortic valvulitis undergoing aortic valve replacement: implication for the treatment of aortic valve involvement in Behcet’s disease

Excerpt

Behcet’s disease (BD) is characterized by inflammation in the media and adventitia of the large vessel and is well known to be one of the causes of aortic regurgitation (AR) [1, 2]. It can lead to unexpected results such as aortic valve replacement (AVR), aortic root replacement, or extensive debridement because these patients often show simultaneous inflammation of the ascending aorta, aortic branch, and aortic valve, which leads to subsequent AR development in up to 44% of patients [1, 3]. It has been reported that 50% of patients with BD aortitis undergoing AVR require re-operation due to aortic valve detachment or paravalvular leakage [4], while patients undergoing surgical treatment for primary AR have more favorable outcomes [5]. …