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Published in: Rheumatology International 12/2009

01-10-2009 | Case Report

Successful twin pregnancy while on cyclophosphamide therapy in a patient with lupus nephritis

Authors: Rajiva Gupta, S. Deepanjali, M. M. Thabah, P. Kaur, S. Gupta

Published in: Rheumatology International | Issue 12/2009

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Excerpt

Intravenous pulse cyclophosphamide is the standard therapy for the treatment of lupus nephritis [1]. Menstrual irregularities and premature ovarian failure can result from the prolonged use of cyclophosphamide [2, 3]. The teratogenic potential of cyclophosphamide has also been reported [4], and its effect has been proven in humans [5]. Its effect on pregnancy outcomes has not been studied well. We report a case of successful twin pregnancy during treatment with cyclophosphamide in a patient with lupus nephritis. …
Literature
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go back to reference Steinberg AD, Steinberg SC (1991) Long-term preservation of renal function in patients with lupus nephritis receiving treatment that includes cyclophosphamide versus those treated with prednisone only. Arthritis Rheum 34:945–950. doi:10.1002/art.1780340803 PubMedCrossRef Steinberg AD, Steinberg SC (1991) Long-term preservation of renal function in patients with lupus nephritis receiving treatment that includes cyclophosphamide versus those treated with prednisone only. Arthritis Rheum 34:945–950. doi:10.​1002/​art.​1780340803 PubMedCrossRef
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go back to reference Huong DL, Amoura Z, Duhaut P et al (2002) Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients. J Rheumatol 9:2571–2576 Huong DL, Amoura Z, Duhaut P et al (2002) Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients. J Rheumatol 9:2571–2576
Metadata
Title
Successful twin pregnancy while on cyclophosphamide therapy in a patient with lupus nephritis
Authors
Rajiva Gupta
S. Deepanjali
M. M. Thabah
P. Kaur
S. Gupta
Publication date
01-10-2009
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 12/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-0860-4

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