Published in:
01-01-2009 | Case Report
A case of limited systemic sclerosis with p-ANCA, complicated by multiple cerebral hemorrhages
Authors:
Bharath Manu Akkara Veetil, Barry M. Schimmer
Published in:
Rheumatology International
|
Issue 3/2009
Login to get access
Abstract
ANCA associated vasculitides are a group of disorders characterized by the presence of necrotizing inflammation of blood vessels that involve venules, capillaries, arterioles, arteries, and veins. They are characterized by the presence of antineutrophil cytoplasmic antibodies (ANCA). ANCA associated vasculitis commonly affects the kidney producing proteinuria, hematuria and variable degrees of renal failure. Other organs involved include the lung, skin and peripheral nervous system. We present a patient with limited systemic sclerosis, who later developed pauci-immune glomerulonephritis with p-ANCA (antimyeloperoxidase) specificity and, whose disease was later complicated by cerebral vasculitis with multiple intracerebral hemorrhages.