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01-06-2008 | Case Report

Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

Authors: Donato Rigante, Rosanna Inzitari, Maurizio Carone, Chiara Fanali, Achille Stabile, Tiziana Cabras, Ettore Capoluongo, Stefania Gaspari, Giuseppe Barone, Massimo Castagnola

Published in: Rheumatology International | Issue 8/2008

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient’s salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.

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Title: Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome
Authors: Donato Rigante
Rosanna Inzitari
Maurizio Carone
Chiara Fanali
Achille Stabile
Tiziana Cabras
Ettore Capoluongo
Stefania Gaspari
Giuseppe Barone
Massimo Castagnola
Publication date: 01-06-2008
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 8/2008
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-008-0524-9

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