Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Rheumatology International
Published in: Rheumatology International 7/2008

Open Access 01-05-2008 | Case Report

Idiopathic hypertrophic cranial pachymeningitis treated by oral methotrexate: a case report and review of literature

Authors: T. Bosman, C. Simonin, D. Launay, S. Caron, A. Destée, L. Defebvre

Published in: Rheumatology International | Issue 7/2008

Login to get access

Abstract

Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare clinical entity, characterized by a chronic inflammation causing thickening of the dura. Adequate therapeutic management is still a matter of debate. We present a patient with an IHCP, non-responsive to corticotherapy. Oral methotrexate was introduced (12.5 mg weekly) and total remission was observed after 6 weeks, both clinically and after neuro-imaging. We conclude that methotrexate can be effective and a therapeutical option in patients with IHCP who are resistant to corticotherapy or present major side-effects of chronic corticosteroids use.
Literature
1.
Charcot JM, Joffroy A (1869) Deux cas d’athrophie musculaire progressive avec lésions de la substance gris et des faisceaux antériolatéraux de la melle épinière. Arch Physiol Norm Pathol 2:354–367, 629–649, 744–769
2.
Naffziger HC, Stern WE (1949) Chronic pachymeningitis: report of a case and review of the literature. Arch Neurol Psychiatry 62:383–411PubMed
3.
Sylaja PN, Cherian PJ, Das CK, Radhakrishnan VV, Radhakrishnan K (2002) Idiopathic hypertrophic cranial pachymeningitis. Neurol India 50:53–59PubMed
4.
D’Andrea G, Trillo G, Celli P, Roperto R, Crispo F, Ferrante L (2004) Idiopathic intracranial hypertrophic pachymeningitis: two case reports and review of the literature. Neurosurg Rev 27:199–204PubMedCrossRef
5.
Lee YC, Cueng YC, Hsu SW, Lui CC (2003) Idiopathic Hypertrophic Cranial pachymeningitis: Case report with 7 years of imaging follow-up. AJNR 24:119–123PubMed
6.
Misra UK, Kalita J (2002) Idiopathic Hyperthophic Pachymeningitis: Easy to Suspect, Difficult to prove. Neurol India 50:4–5PubMed
7.
Prabhakar S, Bhatia R, Lai V, Singh P (2002) Hypertrophic pachymeningitis: varied manifestations of a single disease entity. Neurol India 50:45–52PubMed
8.
De Deus-Silva L, de Queiroz LS, Zanardi Vd Vde A, Ghizone E, da Pereire HC, Malveira GL, Pirani C Jr, Damasceno BP, Cendes F (2003) Hypertrophic pachymeningitis: case report. Arq Neuropsyquiatr 61:107–111
9.
Bang OY, Kim DI, Yoon SR, Choi IS (1998) Idiopathic hypertrophic pachymeningeal lesions: correlation between clinical patterns and neuroimaging characteristics. Eur Neurol 39:49–56PubMedCrossRef
10.
Kupersmith MJ, Martin V, Heller G, Shah A, Mitnick HJ (2004) Idiopathic hypertrophic pachymeningitis. Neurology 62:686–694PubMed
11.
Parney IF, Johnson ES, Allen PB (1997) Idiopathic cranial hypertrophic pachymeningitis responsive to antituberculous therapy: a case report. Neurosurgery 41:965–971PubMedCrossRef
12.
13.
Wang YJ, Fuh JL, Lirng JF, Lu SR, Wang SJ (2004) Headache profile in patients with idiopathic hypertrophic cranial pachymeningitis. Headache 44:916–923PubMedCrossRef
14.
Fain O, Seror O, Wirth JF, Heron C, Mathieu E, Chamouard JM, Guillevin L, Thomas M (1999) Les pachyméningites crâniennes. Rev Méd Interne 20:234–246PubMedCrossRef
15.
Lam BL, Barrett DA, Glaser JS, Schatz NJ, Brown HH (1994) Visual loss from idiopathic intracranial pachymeningitis. Neurology 44:694–698PubMed
16.
Willing SJ, Broghamer W (1992) Internal carotid artery occlusion due to idiopathic cranial pachymeningitis. AJNR 13:1594–1596PubMed
17.
Oku T, Yamashita M, Inoue T, Sayama T, Kodama T, Nagatomi H, Wakisake S (1995) A case of posterior fossa hypertrophic pachymeningitis with hydrocephalus. No To Shinkei 47:569–573PubMed
18.
Eguchi K, Kodama Y, Hotta T, et al (1996) A case of cranial hypertrophic pachymeningitis with intracranial haemorrhage. No To Shinkei 48:475–480PubMed
19.
Takuma H, Shimada H, Inoue Y, Ishimura E, Himuro K, Miki T, Nishizawa (2001) Hypertrophic pachymeningitis with anti-neutrophil cytoplasmic antibody (p-ANCA), and diabetes insipidus. Acta Neurol Scand 104:397–401PubMedCrossRef
20.
Mamelak AN, Kelly WM, Davis RL, Rosenblum ML (1993) Idiopathic hypertrophic cranial pachymeningitis. Report of three cases. J Neurosurg 79:270–276PubMedCrossRef
21.
11Nishio S, Morioka T, Togawa A, Yanase T, Nawata H, Fukui M, Hasuo K (1995) Spontaneous resolution of hypertrophic cranial pachymeningitis. Neurosurg Rev 18:201–204CrossRef
22.
Tanaka M, Suda M, Ishikawa Y, Fujitake J, Fujii H, Tatsuoka Y (1996) Idiopathic hypertrophic cranial pachymeningitis associated with hydrocephalus and myocarditis: Remarkable steroid induced remission of hypertrophic duramater. Neurology 46:554–556PubMed
23.
Hatano N, Behari S, Nagatani T, Kimura M, Ooka K, Saito K, Yoshida J (1999) Idiopathic hypertrophic cranial pachymeningitis: clinicoradiological spectrum and therapeutic options. Neurosurgery 45:1336–1342PubMedCrossRef
24.
Hamilton SF, Smith Ch, Lessell S (1993) Idiopathic hypertrophic cranial pachymeningitis. J Clin Neuroophthalmol 13:127–134PubMed
25.
Masson C, Henin D, Hauw JJ, Rey A, Raverdy P, Masson M (1993) Cranial pachymeningitis of unknown origin: A study of seven cases. Neurology 43:1329–1334PubMed
26.
Botella C, Orozco M, Navarro J, Riesgo P (1994) Idiopathic chronic hypertrophic craniocervical pachyemeningitis: case report. Neurosurgery 35(6):1144–1149PubMedCrossRef
27.
Nishioka H, Ito H, Haraoka J, Takahashi M, Shinmura F (1998) Idiopathic hypertrophic cranial pachymeningitis of the cavernous sinus mimicking lymphocytic hypophysitis. Neurol Med Chir 36(6):377–382CrossRef
28.
Yamamoto T, Goto K, Suzuki A, Nakamura N, Mizuno Y (2000) Long-term improvement of idiopathic hypertrophic cranial pachymeningitis by lymphocytapheresis. Ther Apher 4(4):313–316PubMedCrossRef
29.
Dumont AS, Clark AW, Sevick RJ, Myles ST (2000) Idiopathic hypertrophic pachymeningitis: a report of two patients and review of the literature. Can J Neurol Sci 27(4):333–340PubMed
30.
Rossi S, Giannini F, Cerase A, Bartalini S, Tripodi S, Volpi N, Vatti G, Passero S, Galluzi P, Ulivelli M (2004) Uncommon findings in idiopathic hypertrophic cranial pachymeningitis. J Neurol 251(5):548–555PubMedCrossRef
31.
Kanemoto M, Ota Y, Karahashi T, Nozue N (2005) A case of idiopathic hypertrophic cranial pachymeningitis manifested only by positive rheumatoid factor and abnormal findings of the anterior falx. Rheumatol Int 25(3):230–233PubMedCrossRef
32.
Ruiz-Sandoval JL, Bernard-Medina H, Ramos-Gomez EJ, Romero-Vargas S, Gutierrez-Urena S, Gonzalez-Cornejo S, Chiquete E (2006) Idiopathic hypertrophic cranial pachymeningitis succesfully treated with weekly subcutaneous methotrexate. Acta Neurochir 148:1011–1014CrossRef
33.
1Rudnik A, Larysz D, Gamrot J, Rudnik A, Skorupa A, Bierzynska-macyszyn G, Bazowski P (2007) Idiopathic hypertrophic pachymeningitis—case report and literature review. Folia Neuropathol 45(1):36–42
Metadata
Title
Idiopathic hypertrophic cranial pachymeningitis treated by oral methotrexate: a case report and review of literature
Authors
T. Bosman
C. Simonin
D. Launay
S. Caron
A. Destée
L. Defebvre
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 7/2008
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-007-0504-5

Other articles of this Issue 7/2008

Rheumatology International 7/2008 Go to the issue

Original Article

The role of cytokines in inflammatory response after total knee arthroplasty in patients with rheumatoid arthritis

Original Article

Definition of disease duration in ankylosing spondylitis

Original Article

Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population

Original Article

Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss

Case Report

Onset and enhancement of systemic sclerosis after treatments for multiple sclerosis

Original Article

Comparison of the expression profile of apoptosis-associated genes in rheumatoid arthritis and osteoarthritis
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits