Top

Published in:

01-06-2006 | Original Article

Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India

Authors: R. Venkatraman, S. Singh, R.W. Minz

Published in: Rheumatology International | Issue 8/2006

Abstract

A study of organ-specific and organ-nonspecific autoantibodies was carried out in 21 children being followed up after a diagnosis of Kawasaki disease at a tertiary care center of North India. Anti-nuclear antibodies were detected in 9.5% patients while anti-thyroid microsomal antibodies were detected in 23.9% patients. Other autoantibodies (e.g. anti-parietal cell antibody, anti-liver kidney microsomal antibody anti-neutrophil cytoplasmic antibody, anti-mitochondrial antibody and anti-smooth muscle antibody) were not detected in any of our patients. Children with Kawasaki disease need to be monitored for the development of autoantibodies during follow-up.

Cassidy JT, Petty RE (2001) Vasculitis. Kawasaki disease. In: Cassidy JT, Petty RE (eds) Textbook of pediatric rheumatology, 4th edn. W.B. Saunders Company, Philadelphia

Soppi E, Salo E, Pelkonen P (1992) Antibodies against neutrophil cytoplasmic components in Kawasaki disease. Acta Pathol Microbiol Immunol Scand 100(3):369–372

Savage CO, Tizard J, Jayne D, Lockwood CM, Dillon MJ (1989) Antineutrophilic cytoplasmic antibodies in Kawasaki disease. Arch Dis Child 64:360–363PubMed

Tizard EJ, Baguley E, Hughes GR, Dillon M (1991) Antiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease. Arch Dis Child 66:189–192PubMedCrossRef

Salo E, Kekomaki R, Pelkonen P, Ruuskanen O, Viander M, Wagner O (1988) Kawasaki disease: monitoring of circulating immune complexes. Eur J Pediatr 147:377–380PubMedCrossRef

Cunningham MW, Meissner CH, Heuser JS, Pietra BA, Kurahara DK, Leung DYM (1999) Anti-human cardiac myosin autoantibodies in Kawasaki syndrome. J Immunol 163:1060–1065PubMed

Guzman J, Fung M, Petty RE (1994) Diagnostic value of anti-neutrophil cytoplasmic and anti-endothelial cell antibodies in early Kawasaki disease. J Pediatr 124:917–920PubMedCrossRef

Gupta M, Johann-Liang R, Bussel JB, Gersony WM, Lehman TJ (2002) Elevated IgA and IgM anticardiolipin antibodies in acute Kawasaki disease. Cardiology 97:180–182PubMedCrossRef

Lee LA, Burns J, Glode M, Harmon C, Weston WL (1983) No autoantibodies to nuclear antigens in the Kawasaki disease. N Engl J Med 308:1034PubMed

10.

Birdi N, Laxer RM, Silverman ED (1991) Antineutrophil cytoplasmic antibodies in Kawasaki disease. Arthritis Rheum 34(Suppl):70

11.

Serodia-AMC. Semi-quantitative microtiter particle agglutination test for in vitro diagnostic detection and titration of microsomal antibodies in human serum. Fujirebio Inc., Tokyo, Japan

12.

Shulman ST, Bass JL, Bierman F, Burns JC, Chung K, Dillon MJ, et al (1989) Management of Kawasaki syndrome: a consensus statement prepared by North American participants of the third international Kawasaki disease symposium, Tokyo, Japan, December 1988. Pediatr Infect Dis J 8(Suppl):663–667

13.

Kato H, Inoue O, Akagi T (1988) Kawasaki disease: cardiac problems and management. Pediatr Rev 9:209–217PubMedCrossRef

14.

Leung DY (1989) The immunologic effects of IVIG in Kawasaki disease. Int Rev Immunol 5:197–202PubMedCrossRef

15.

Rowley AH, Shulman ST (1987) The search for the etiology of Kawasaki disease. Pediatr Infect Dis J 6:506–508PubMed

16.

Leung DY, Siege RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha RS (1982) Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Clin Immunol Immunopathol 23:100–112PubMedCrossRef

17.

Leung DY, Collins T, Lapierre LF, et al (1986) IgM antibodies in the acute phase of KD lysed cultured vascular endothelial cells stimulated by gamma interferon. J Clin Invest 77:1428–1435PubMedCrossRef

18.

Suzuki H, Noda E, Miyawaki M, Takeuchi T, Uemura S, Koike M (2001) Serum levels of neutrophil activation cytokines in Kawasaki disease. Pediatr Int 43(2):115–119PubMedCrossRef

19.

Falcini TF, Trapani S, Turchini S, et al (1997) Immunological findings in Kawasaki disease: an evaluation in a cohort of Italian children. Clin Exp Rheumatol 15(6):685–689PubMed

20.

Nonoyama S (1991) Immunological abnormalities and endothelial cell injury in Kawasaki disease. Acta Pediatr Jpn 33:752

21.

Lin CY, Hwang B (1987) Serial immunologic studies in patients with mucocutaneous lymph node syndrome (Kawasaki disease). Ann Allergy 59:291–297PubMed

22.

Ohshio G, Furukawa F, Khine M, Yoshioka H, Kudo H, Hamashima Y (1987) High levels of IgA-containing circulating immune complexes and secretory IgA in Kawasaki disease. Microbiol Immunol 31:891–898PubMed

23.

Li C, Yang X, Shen J, Li Y, Jiang L (1990) Immunoglobulin G subclasses in serum and circulating immune complexes in patients with Kawasaki syndrome. Pediatr Infect Dis J 9:544–547PubMedCrossRef

24.

Takeshita S, Kawase H, Shimizu T, Yoshida M, Sekine I (2002) Increased production of serum IgA—class antibody to lipid A in Kawasaki disease. Pediatr Int 44:5–11PubMedCrossRef

25.

Rowley AH, Shulman ST, Spike BT, Mask CA, Baker SC (2001) Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. J Immunol 166(2):1334–1343PubMed

26.

Krasovec S, Bezrodnik L, Gaillard MI, et al (2001) Kawasaki disease. Immunological evaluation of 26 cases. Medicina 61(1):8PubMed

27.

Nash MC, Shah V, Reader JA (1995) Anti-neutrophil cytoplasmic antibodies and anti-endothelial cell antibodies are not increased in Kawasaki disease. Br J Rheumatol 34(9):882–887PubMedCrossRef

28.

Rider LG, Wener MH, French J, et al (1993) Autoantibody production in Kawasaki syndrome. Clin Exp Rheumatol 11(4):445–449PubMed

29.

Vaarala O, Salo E, Pelkonen P, Palosuo T, Aho K (1990) Anticardiolipin response in Kawasaki disease. Acta Pediatr Scand 79:804–809CrossRef

30.

Nomura Y, Yoshinaga M, Oku S, Kono Y, Yuasa Y, Noda T (1993) Estimation of myocardial damage in Kawasaki disease using antimyosin antibody. Acta Paediatr Jpn 35(5):412–417PubMed

31.

Singh S, Kumar L, Khetarpal R, Aggarwal P, Marwaha RK, Minz RW, Sehgal S (1997) Clinical and immunological profile of SLE: some unusual features. Indian Pediatr 34:979–986PubMed

32.

Kumar L, Singh S, Goraya JS, Uppal B, Kakkar S, Walker R, Sehgal S (1998) Henoch-Schonlein purpura: the Chandigarh experience. Indian Pediatr 35(1):19–25PubMed

33.

Singh S, Salaria M, Kumar L, Minz R, Datta U, Sehgal S (1999) Clinico-immunological profile of juvenile rheumatoid arthritis at Chandigarh. Indian Pediatr 36(5):449–454PubMed

34.

Singh S, Kumar L, Shankar KR (1997) Juvenile dermatomyositis in North India. Indian Pediatr 34(3):193–198PubMed

35.

Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Immunofluroscent antinuclear antibody test. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp724–729

36.

Sehgal S, Aikat BK, Pasricha N (1978) Diagnostic significance of antinuclear antibodies. Indian J Med Res 67:116–128PubMed

37.

Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Antibodies to tissue specific endocrine, gastrointestinal and surface receptor antigen. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp765–774

38.

Rose NR, Macario EC, Fahey JL, Fereidman H (1992) Antineutrophil cytoplasmic autoantibodies. In: Manual of clinical laboratory immunology, 4th edn. American Society of Microbiology, WA, pp781–785

39.

Burek CL (1992) Autoantibodies, test for. In: Roitt IM, Delves PJ (eds) Encyclopedia of immunology, Academic Press, London, pp176–180

40.

Lahita RG, Chiorazzi N, Reeves WH (2000) How to interpret autoimmune tests. In: textbook of autoimmune disease. Lippincot Williams and Wilkins, Philadelphia, pp727–752

41.

Savige J, Gillis D, Benson E, Davies D, Esnault V, Falk RJ, et al (1999) International consensus statement on testing and reporting of antineutrophil cytoplasmic antibodies (ANCA). Am J Clin Pathol 111(4):507–513PubMed

42.

Newburger JW, Sanders SP, Burns JC, Parmess IA, Beiser AS Colan SD (1989) Left ventricular contractility and function in Kawasaki syndrome. Effect of intravenous γ-globulin. Circulation 79:1237–1246PubMed

Title: Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India
Authors: R. Venkatraman
S. Singh
R.W. Minz
Publication date: 01-06-2006
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 8/2006
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-005-0050-y

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Study of the autoantibody profile after the acute phase of Kawasaki disease in a cohort of children from North India

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 8/2006

Classic disease modifying anti-rheumatic drugs (DMARDs) in combination with infliximab. The Finnish experience

Novel transdermal photodynamic therapy using ATX-S10·Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice

Aspergillus peritonitis in a lupus patient on chronic peritoneal dialysis

Health-related quality of life in rheumatoid arthritis: therapeutic education plus pharmacological treatment versus pharmacological treatment only

SLE-associated transverse myelitis successfully treated with Rituximab (anti-CD20 monoclonal antibody)

The presence of anti-mitochondrial antibodies in Chinese patients with liver involvement in systemic lupus erythematosus

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page