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Rheumatology International
Published in: Rheumatology International 4/2005

01-05-2005 | Case Report

Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy

Authors: Byung-Ryul Choi, Myung-Ju Ahn, Woong Soo Lee, Tae-Hwan Kim, Sang-Cheol Bae, Jae-Bum Jun

Published in: Rheumatology International | Issue 4/2005

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Abstract

Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (total dose 1702.5 mg). This may be the first such case reported in the literature.
Literature
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McKendry RJR, Dale P (1993) Adverse effects of low dose methotrexate therapy in RA. J Rheumatol 20:1850–1856PubMed
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Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1985) Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British cooperative group. Ann Intern Med 103:620–625PubMed
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Kremer JM, Lee JK (1986) The safety and efficacy of the use of methotrexate in long-term therapy for rheumatoid arthritis. Arthritis Rheum 29:822–831PubMed
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Weinblatt ME (1985) Toxicity of low dose methotrexate in rheumatoid arthritis. J Rheumatol 12 [Suppl 12]:35–39
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Rosenthal NS, Farhi DC (1996) Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy. Am J Clin Pathol 106:676–679PubMed
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Pointud P, Prudat M, Peron JM (1993) Acute leukemia after low dose methotrexate therapy in a patient with rheumatoid arthritis. J Rheumatol 20:1215–1216PubMed
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Kolte B, Baer AN, Sait SN, O’Loughlin KL, Stewart CC, Barcos M, Wetzler M, Baer MR (2001) Acute myeloid leukemia in the setting of low dose weekly methotrexate therapy for rheumatoid arthritis. Leuk Lymphoma 42:371–378PubMed
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Dubin Kerr L, Troy K, Isola L (1995) Temporal association between the use of methotrexate and development of leukemia in 2 patients with rheumatoid arthritis. J Rheumatol 22:2356–2358PubMed
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Metadata
Title
Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy
Authors
Byung-Ryul Choi
Myung-Ju Ahn
Woong Soo Lee
Tae-Hwan Kim
Sang-Cheol Bae
Jae-Bum Jun
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 4/2005
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-004-0502-9

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