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Rheumatology International

Published in:

01-07-2005 | Original Article

The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2

Authors: Eldad Ben-Chetrit, Ruth Fischel, Burkhard Hinz, Micha Levy

Published in: Rheumatology International | Issue 5/2005

Abstract

Objective

The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX).

Methods

Measurement of COX-1 and COX-2 activity was performed by using whole blood assay. Serum thromboxane (TXA) and plasma prostaglandin 2 (PGE2) levels were determined using a commercially available enzyme immunoassay kit. Celecoxib, etodolac, and nimesulide were also tested as controls. Since the study was intended to find a qualitative effect rather than a quantitative relationship between the drugs and the enzymes, we used higher concentrations than the therapeutic range.

Results

Colchicine did not have an inhibitory effect on cyclo-oxygenases. Hydroxychloroquine had a mild inhibitory effect in a relatively high concentration. As expected, celecoxib, etodolac, and nimesulide did have an inhibitory effect on the cyclo-oxygenases.

Conclusions

Neither colchicine nor hydroxychloroquine exert their anti-inhibitory effect through inhibition of cyclo-oxygenases.

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Title: The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2
Authors: Eldad Ben-Chetrit
Ruth Fischel
Burkhard Hinz
Micha Levy
Publication date: 01-07-2005
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 5/2005
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-004-0442-4

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The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2

Abstract

Objective

Methods

Results

Conclusions

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Abstract

Objective

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Conclusions

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