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01-01-2005 | Original Article

Ghrelin plasmatic levels in patients with fibromyalgia

Authors: Miguel Otero, Ruben Nogueiras, Francisca Lago, Juan Meijide, Juan Amarelo, Antonio Mera, Juan Gomez-Reino, Oreste Gualillo

Published in: Rheumatology International | Issue 1/2005

Abstract

Ghrelin is a recently discovered 28 amino acid peptide that regulates GH secretion and energy homeostasis. In fibromyalgia (FM) there are alterations in the pituitary-hypothalamic axis, particularly in the growth hormone (GH) secretion pattern. Whether this anomalous secretion of GH pertains to abnormal levels of ghrelin is still unknown. The purpose of this study was to investigate plasma ghrelin levels in patients with fibromyalgia (FM) compared with healthy controls. Plasmatic ghrelin concentrations were determined by a double antibody radioimmunoassay in 19 patients with FM and 14 healthy controls. Compared with controls, patients with FM did not show any significant differences of ghrelin plasmatic levels. In conclusion, FM is not associated with deviation in ghrelin concentrations. Existing alterations in FM with respect to GH are unlikely due to circulating ghrelin.

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Title: Ghrelin plasmatic levels in patients with fibromyalgia
Authors: Miguel Otero
Ruben Nogueiras
Francisca Lago
Juan Meijide
Juan Amarelo
Antonio Mera
Juan Gomez-Reino
Oreste Gualillo
Publication date: 01-01-2005
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 1/2005
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-003-0390-4

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