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Published in: Rheumatology International 2/2004

01-03-2004 | Original Article

Plasminogen activator inhibitor-1 as a link between pathological fibrinolysis and arthritis of Behçet's disease

Authors: M. Akif Öztürk, İhsan Ertenli, Sedat Kiraz, İbrahim C. Haznedaroğlu, İsmail Çelik, Şerafettin Kirazlı, Meral Çalgüneri

Published in: Rheumatology International | Issue 2/2004

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Abstract

Behçet's disease (BD) commonly presents with articular manifestations and thrombotic vasculopathy. Arthritis of BD characteristically demonstrates a recurrent and nondestructive course. The pathobiological basis of the thrombotic vasculopathy and protective factors against cartilage destruction in arthritis of BD have not been elucidated. Apart from being involved in fibrinolysis and thrombolysis, the plasminogen activation system can contribute to the pathogenesis of destructive joint diseases such as rheumatoid arthritis (RA). Plasminogen activator inhibitor-1 (PAI-1) is a well known fibrinolysis inhibitor. In this study, local synovial fluid and circulating plasma PAI-1 concentrations of BD were assessed in comparison to RA patients and healthy controls to investigate the nonerosive, nondestructive nature of Behçet arthritis. Twelve patients with BD (mean age 34±11 years, males:females 6:6), 15 with RA (mean age 36±8 years, males:females 3:12), and 15 healthy adults (mean age 32±10 years, males:females 6:9) were included in this study. Plasma PAI-1 antigen levels and PAI-1 activities were significantly greater in BD patients than in RA patients and healthy controls (P<0.001). Synovial fluid levels of both parameters were also higher than in RA patients (P<0.001). These results suggest that PAI-1 may promote hypofibrinolysis of Behçet's vasculopathy and also have a protective role in the arthritis of BD.
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Metadata
Title
Plasminogen activator inhibitor-1 as a link between pathological fibrinolysis and arthritis of Behçet's disease
Authors
M. Akif Öztürk
İhsan Ertenli
Sedat Kiraz
İbrahim C. Haznedaroğlu
İsmail Çelik
Şerafettin Kirazlı
Meral Çalgüneri
Publication date
01-03-2004
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 2/2004
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-003-0324-1

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