Skip to main content
Top
Published in: Rheumatology International 4/2003

01-07-2003 | Original Article

Detecting abnormal regional cerebral blood flow in patients with primary Sjögren's syndrome by technetium-99m ethyl cysteinate dimer single photon emission computed tomography of the brain—a preliminary report

Authors: W. S. Huang, P. Y. Chiu, A. Kao, C. H. Tsai, C. C. Lee

Published in: Rheumatology International | Issue 4/2003

Login to get access

Abstract

Technetium-99m ethyl cysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) was used to detect abnormal regional cerebral blood flow (rCBF) in 32 female patients with primary Sjögren's syndrome (PSS) showing definite neuropsychiatric symptoms/signs and normal brain magnetic resonance imaging (MRI) findings. It demonstrated hypoperfusion brain lesions in 18 (56.3%) of the patients, most frequently in the parietal lobes, and appears to be a sensitive tool for this clinical application.
Literature
1.
go back to reference Alexander E (1992) Central nervous system disease in Sjögren's syndrome: new insights into immunopathogenesis. Rheum Dis Clin North Am 18:637–672PubMed Alexander E (1992) Central nervous system disease in Sjögren's syndrome: new insights into immunopathogenesis. Rheum Dis Clin North Am 18:637–672PubMed
2.
go back to reference Farnam J, Jorizzo JL, Grant JA, Lavastida MT, Ichikawa Y, Daniels JC (1984) Sjögren's syndrome presenting with hypereosinophilia, lymphopenia and circulating immune complexes. Clin Exp Rheumatol 2:41–46 Farnam J, Jorizzo JL, Grant JA, Lavastida MT, Ichikawa Y, Daniels JC (1984) Sjögren's syndrome presenting with hypereosinophilia, lymphopenia and circulating immune complexes. Clin Exp Rheumatol 2:41–46
3.
go back to reference Fox RI, Howell FV, Bone RC, Michelson P (1984) Primary Sjögren's syndrome: clinical and immunopathological features. Semin Arthritis Rheum 14:77–105PubMed Fox RI, Howell FV, Bone RC, Michelson P (1984) Primary Sjögren's syndrome: clinical and immunopathological features. Semin Arthritis Rheum 14:77–105PubMed
4.
go back to reference Sjögren H (1935) Zur Kenntnis der Keratoconjunctivitis Sicca II. Allgemeine Symptomatologie und Ätiologie. Acta Opthalmol (Kbh) 13:1–39 Sjögren H (1935) Zur Kenntnis der Keratoconjunctivitis Sicca II. Allgemeine Symptomatologie und Ätiologie. Acta Opthalmol (Kbh) 13:1–39
5.
go back to reference Hietaharju A, Yli-Kerttula U, Hakkinen V, Frey H (1990) Nervous system manifestations in Sjögren's syndrome. Acta Neurol Scand 81:144–152PubMed Hietaharju A, Yli-Kerttula U, Hakkinen V, Frey H (1990) Nervous system manifestations in Sjögren's syndrome. Acta Neurol Scand 81:144–152PubMed
6.
go back to reference Alexander EL, Beall S, Provost TT (1989) Magnetic resonance imaging (MRI) in primary Sjögren's syndrome with central nervous system disease (CNS-SS): new clues to pathogenesis. Arthritis Rheum 29:S63 Alexander EL, Beall S, Provost TT (1989) Magnetic resonance imaging (MRI) in primary Sjögren's syndrome with central nervous system disease (CNS-SS): new clues to pathogenesis. Arthritis Rheum 29:S63
7.
go back to reference Manthorpe R, Manthorpe T, Sjoberg S (1992) Magnetic resonance imaging of the brain in patients with primary Sjögren's syndrome. Scand J Rheumatol 21:148–149PubMed Manthorpe R, Manthorpe T, Sjoberg S (1992) Magnetic resonance imaging of the brain in patients with primary Sjögren's syndrome. Scand J Rheumatol 21:148–149PubMed
8.
go back to reference Moutsopoulos HM, Sarmas JH, Talal N (1993) Is central nervous system involvement a systemic manifestation of primary Sjögren's syndrome? Rheum Dis Clin North Am 19:909–912PubMed Moutsopoulos HM, Sarmas JH, Talal N (1993) Is central nervous system involvement a systemic manifestation of primary Sjögren's syndrome? Rheum Dis Clin North Am 19:909–912PubMed
9.
go back to reference Kao CH, Lan JL, ChangLai SP, Chieng PU (1998) Technetium-99m-HMPAO brain SPECT in Sjögren's syndrome. J Nucl Med 39:773–777PubMed Kao CH, Lan JL, ChangLai SP, Chieng PU (1998) Technetium-99m-HMPAO brain SPECT in Sjögren's syndrome. J Nucl Med 39:773–777PubMed
10.
go back to reference Neirinckx RD, Canning LR, Piper IM, Nowotnik DP, Pickett RD, Holmes RA, Volkert WA, Forster AM, Weisner PS, Marriott JA (1987) Technetium-99m d,l-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med 28:191–202 Neirinckx RD, Canning LR, Piper IM, Nowotnik DP, Pickett RD, Holmes RA, Volkert WA, Forster AM, Weisner PS, Marriott JA (1987) Technetium-99m d,l-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med 28:191–202
11.
go back to reference Juni JE, Waxman AD, Devous MD Sr, Tikofsky RS, Ichise M, Van Heertum RL, Holman BL, Carretta RF, Chen CC (1998) Procedure guideline for brain perfusion SPECT using technetium-99m radiopharmaceuticals. J Nucl Med 39:923–926PubMed Juni JE, Waxman AD, Devous MD Sr, Tikofsky RS, Ichise M, Van Heertum RL, Holman BL, Carretta RF, Chen CC (1998) Procedure guideline for brain perfusion SPECT using technetium-99m radiopharmaceuticals. J Nucl Med 39:923–926PubMed
12.
go back to reference Leveille J, Demonceau G, De Roo M, Rigo P, Taillefer R, Morgan RA, Kupranick D, Walovitch RC (1989) Characterization of Tc-99m-L,L-ECD for brain perfusion. Part 2. Biodistribution and brain imaging in humans. J Nucl Med 30:1902–1910PubMed Leveille J, Demonceau G, De Roo M, Rigo P, Taillefer R, Morgan RA, Kupranick D, Walovitch RC (1989) Characterization of Tc-99m-L,L-ECD for brain perfusion. Part 2. Biodistribution and brain imaging in humans. J Nucl Med 30:1902–1910PubMed
13.
go back to reference Asenbaum S, Brucke T, Pirker W, Pietrzyk U, Podreka I (1998) Imaging of cerebral blood flow with technetium-99m-HMPAO and technetium-99m-ECD: a comparison. J Nucl Med 39:613–618PubMed Asenbaum S, Brucke T, Pirker W, Pietrzyk U, Podreka I (1998) Imaging of cerebral blood flow with technetium-99m-HMPAO and technetium-99m-ECD: a comparison. J Nucl Med 39:613–618PubMed
14.
go back to reference Koyama M, Kawashima R, Ito H, Ono S, Sato K, Goto R, Kinomura S, Yoshioka S, Sato T, Fukuda H (1997) SPECT imaging of normal subjects with technetium-99m-HMPAO and technetium-99m-ECD. J Nucl Med 38:587–592PubMed Koyama M, Kawashima R, Ito H, Ono S, Sato K, Goto R, Kinomura S, Yoshioka S, Sato T, Fukuda H (1997) SPECT imaging of normal subjects with technetium-99m-HMPAO and technetium-99m-ECD. J Nucl Med 38:587–592PubMed
15.
go back to reference van Dyck CH, Lin CH, Smith EO, Wisniewski G, Cellar J, Robinson R, Narayan M, Bennett A, Delaney RC, Bronen RA, Hoffer PB (1996) Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease. J Nucl Med 37:1749–1755PubMed van Dyck CH, Lin CH, Smith EO, Wisniewski G, Cellar J, Robinson R, Narayan M, Bennett A, Delaney RC, Bronen RA, Hoffer PB (1996) Comparison of technetium-99m-HMPAO and technetium-99m-ECD cerebral SPECT images in Alzheimer's disease. J Nucl Med 37:1749–1755PubMed
16.
go back to reference Leveille J, Demonceau G, Walovitch RC (1992) Intrasubject comparison between technetium-99m-ECD and technetium-99m-HMPAO in healthy human subjects. J Nucl Med 33:480–484PubMed Leveille J, Demonceau G, Walovitch RC (1992) Intrasubject comparison between technetium-99m-ECD and technetium-99m-HMPAO in healthy human subjects. J Nucl Med 33:480–484PubMed
17.
go back to reference Kuwabara Y, Ichiya Y, Otsuka M, Tahara T, Fukumura T, Gunasekera R, Masuda K (1990) Differential diagnosis of bilateral parietal abnormalities in I-123 IMP SPECT imaging. Clin Nucl Med 15:893–899 Kuwabara Y, Ichiya Y, Otsuka M, Tahara T, Fukumura T, Gunasekera R, Masuda K (1990) Differential diagnosis of bilateral parietal abnormalities in I-123 IMP SPECT imaging. Clin Nucl Med 15:893–899
18.
go back to reference DeVolder AG, Goffinet AM, Bol A, Michel C, de-Barsy T, Laterre C (1990) Brain glucose metabolism in postanoxic syndrome. Positron emission tomographic study. Arch Neurol 47:197–204PubMed DeVolder AG, Goffinet AM, Bol A, Michel C, de-Barsy T, Laterre C (1990) Brain glucose metabolism in postanoxic syndrome. Positron emission tomographic study. Arch Neurol 47:197–204PubMed
19.
go back to reference Devinsky O, Petito CK, Alonso DR (1988) Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis, heart emboli and thrombotic thrombocytopenia purpura. Ann Neurol 23:380–384 Devinsky O, Petito CK, Alonso DR (1988) Clinical and neuropathological findings in systemic lupus erythematosus: the role of vasculitis, heart emboli and thrombotic thrombocytopenia purpura. Ann Neurol 23:380–384
20.
go back to reference Nishimura H, Tachibana H, Makiura N, Okuda B, Sugita M (1994) Corticosteroid-responsive parkinsonism associated with primary Sjögren's syndrome. Clin Neurol Neurosurg 96:327–331PubMed Nishimura H, Tachibana H, Makiura N, Okuda B, Sugita M (1994) Corticosteroid-responsive parkinsonism associated with primary Sjögren's syndrome. Clin Neurol Neurosurg 96:327–331PubMed
21.
go back to reference Gerraty RP, McKelvie PA, Byrne E (1993) Aseptic meningoencephalitis in primary Sjögren's syndrome. Response to plasmapheresis and absence of CNS vasculitis at autopsy. Acta Neurol Scand 88:309–311PubMed Gerraty RP, McKelvie PA, Byrne E (1993) Aseptic meningoencephalitis in primary Sjögren's syndrome. Response to plasmapheresis and absence of CNS vasculitis at autopsy. Acta Neurol Scand 88:309–311PubMed
22.
go back to reference Berman JL, Kashii S, Trachtman MS, Burde RM (1990) Optic neuropathy and central nervous system disease secondary to Sjögren's syndrome in a child. Ophthalmology 97:1606–1609PubMed Berman JL, Kashii S, Trachtman MS, Burde RM (1990) Optic neuropathy and central nervous system disease secondary to Sjögren's syndrome in a child. Ophthalmology 97:1606–1609PubMed
23.
go back to reference de la Monte SM, Hutchins GM, Gupta PK (1983) Polymorphous meningitis with atypical mononuclear cells in Sjögren's syndrome. Ann Neurol 14:455–461 de la Monte SM, Hutchins GM, Gupta PK (1983) Polymorphous meningitis with atypical mononuclear cells in Sjögren's syndrome. Ann Neurol 14:455–461
24.
go back to reference Alexander EL, Provost TT, Stevens MB, Alexander GE (1982) Neurologic complications of primary Sjögren's syndrome. Medicine 61:247–257 Alexander EL, Provost TT, Stevens MB, Alexander GE (1982) Neurologic complications of primary Sjögren's syndrome. Medicine 61:247–257
Metadata
Title
Detecting abnormal regional cerebral blood flow in patients with primary Sjögren's syndrome by technetium-99m ethyl cysteinate dimer single photon emission computed tomography of the brain—a preliminary report
Authors
W. S. Huang
P. Y. Chiu
A. Kao
C. H. Tsai
C. C. Lee
Publication date
01-07-2003
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 4/2003
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-002-0272-1

Other articles of this Issue 4/2003

Rheumatology International 4/2003 Go to the issue