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Seminars in Immunopathology
Published in: Seminars in Immunopathology 1/2019

01-01-2019 | Review

Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells

Authors: Michelle L. Saetersmoen, Quirin Hammer, Bahram Valamehr, Dan S. Kaufman, Karl-Johan Malmberg

Published in: Seminars in Immunopathology | Issue 1/2019

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Abstract

Cell therapy is emerging as a very promising therapeutic modality against cancer, spearheaded by the clinical success of chimeric antigen receptor (CAR) modified T cells for B cell malignancies. Currently, FDA-approved CAR-T cell products are based on engineering of autologous T cells harvested from the patient, typically using a central manufacturing facility for gene editing before the product can be delivered to the clinic and infused to the patients. For a broader implementation of advanced cell therapy and to reduce costs, it would be advantageous to use allogeneic “universal” cell therapy products that can be stored in cell banks and provided upon request, in a manner analogous to biopharmaceutical drug products. In this review, we outline a roadmap for development of off-the-shelf cell therapy based on natural killer (NK) cells derived from induced pluripotent stem cells (iPSCs). We discuss strategies to engineer iPSC-derived NK (iPSC-NK) cells for enhanced functional potential, persistence, and homing.
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Metadata
Title
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
Authors
Michelle L. Saetersmoen
Quirin Hammer
Bahram Valamehr
Dan S. Kaufman
Karl-Johan Malmberg
Publication date
01-01-2019
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 1/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-018-0721-x

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