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Seminars in Immunopathology
Published in: Seminars in Immunopathology 6/2017

01-11-2017 | Review

In utero development of memory T cells

Authors: Dania Zhivaki, Richard Lo-Man

Published in: Seminars in Immunopathology | Issue 6/2017

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Abstract

Pathogen-specific immune memory develops subsequent to primary exposure to antigen, mainly in the context of infection or vaccination to provide protection. Although a safe fetal life requires a tolerogenic environment in order to circumvent unnecessary inflammatory responses, it needs to be prepared in utero to face the microbial environment outside the womb. The possibility of immune memory generation in the fetus would help such transition providing protection in early life. This requires fetal T cell exposure to foreign antigens presented by dendritic cells. There are evidences of fetal T cell priming in several cases of congenital infections or in uninfected children born of infected mothers. Fetal T cell memory seems to arise also without any reported infection during pregnancy. Such memory T cells display various effector functions, including Th1, Th2, or Th17 profiles, raising the issue of benefits and risks for postnatal life when considering maternal vaccination, susceptibility to infection, or environmental allergen sensitization.
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Metadata
Title
In utero development of memory T cells
Authors
Dania Zhivaki
Richard Lo-Man
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 6/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-017-0650-0

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